Aurintricarboxylic acid
- CAS No.
- 4431-00-9
- Chemical Name:
- Aurintricarboxylic acid
- Synonyms
- AURINTRICARBONIC ACID;bis(2-hydroxybenzoic acid);ATA;SKL331;e)-6-oxo-;aluminonfreeacid;TIMTEC-BB SBB005410;aurintricarboxylicaci;LABOTEST-BB LT00080677;Aurintricarboxylic acid
- CBNumber:
- CB7463004
- Molecular Formula:
- C22H14O9
- Molecular Weight:
- 422.34
- MDL Number:
- MFCD00011663
- MOL File:
- 4431-00-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 300 °C(lit.) |
|---|---|
| Boiling point | 458.99°C (rough estimate) |
| Density | 1.3860 (rough estimate) |
| refractive index | 1.6230 (estimate) |
| storage temp. | +15C to +30C |
| solubility | 1 M NH4OH: 10 mg/mL |
| form | powder |
| pka | 2.20±0.20(Predicted) |
| color | dark red to brown |
| Water Solubility | Insoluble in water. |
| BRN | 2228904 |
| Major Application |
diagnostic assay manufacturing hematology histology |
| InChI | 1S/C22H14O9/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31) |
| InChIKey | GIXWDMTZECRIJT-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cc(ccc1O)C(\c2ccc(O)c(c2)C(O)=O)=C3\C=CC(=O)C(=C3)C(O)=O |
| CAS DataBase Reference | 4431-00-9(CAS DataBase Reference) |
| FDA UNII | NP9O8E29QW |
| EPA Substance Registry System | Benzoic acid, 5-[(3-carboxy-4-hydroxyphenyl)(3-carboxy-4-oxo-2,5-cyclohexadien-1-ylidene)methyl]-2-hydroxy- (4431-00-9) |
| UNSPSC Code | 12352106 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | GU4790000 | |||||||||
| TSCA | TSCA listed | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Aurintricarboxylic acid price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A1895 | Aurintricarboxylic acid practical grade, ≥85% (titration), powder | 4431-00-9 | 5g | $75.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 189400 | Aurintricarboxylic Acid | 4431-00-9 | 100mg | $61.9 | 2026-04-30 | Buy |
| TRC | TRC-A794803-5G | Aurintricarboxylic Acids (Technical Grade) | 4431-00-9 | 5g | $142 | 2026-06-03 | Buy |
| TRC | TRC-A794803-10G | Aurintricarboxylic Acids (Technical Grade) | 4431-00-9 | 10g | $193 | 2026-06-03 | Buy |
| TRC | TRC-A794803-100MG | Aurintricarboxylic Acids (Technical Grade) | 4431-00-9 | 100mg | $73 | 2026-06-03 | Buy |
Aurintricarboxylic acid Chemical Properties, Uses, Production
Chemical Properties
deep red coarse crystalline powder
Uses
endonuclease inhibitor; apoptosis inhibitor, topoisomerase II inhibitor
Uses
Aurintricarboxylic acid is employed as a powerful inhibitor of cellular processes, including apoptosis, that are dependent on the formation of protein-nucleic acid complexes. It binds to a FGF and reduces its angiogenic activity. Aurintricarboxylic Acid has been shown to inhibit apoptotic cell death in various cell types induced by a variety of factors. It Inhibits protein-nucleic acid interactions. It stimulates the tyrosine phosphorylation of MAP kinases.
Definition
ChEBI: A member of the class of quinomethanes that is 3-methylidene-6-oxocyclohexa-1,4-diene-1-carboxylic acid in which the methylidene hydrogens are replaced by 4-carboxy-3-hydroxyphenyl groups. The trisodium salt is the biological stain 'chrome violet CG' while the triammonium salt is 'aluminon'.
Biological Activity
Readily polymerizes in aqueous solution, forming a stable free radical th at inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase Cγ in PC12 cells. Inhibits apoptosis. It prevents down-regulation of Ca2+ -impermeable GluR2 receptors and inhibits calpain, a Ca2+ -activated protease th at is activated during apoptosis.
Purification Methods
The acid is dissolved in aqueous NaOH, NaHSO3 solution is added until the colour is discharged and then the tricarboxylic acid is precipitated with HCl. [Heisig & Lauer Org Synth Coll Vol I 54 1941, Beilstein 10 IV 4161]. Do not extract the acid with hot water because it softens, forming a viscous mass. Make a solution in aqueous NH3. Aluminon is the NH4 salt.
Aurintricarboxylic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Shanghai Ruji Biology Technology Co., Ltd. | +86-21-65211385-8001 36031160 | sales@shruji.com | China | 3223 | 55 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
View Latest Price from Aurintricarboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-10 | Aurintricarboxylic acid
4431-00-9
|
$30.00-61.00 | 85.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | AURINTRICARBOXYLIC ACID
4431-00-9
|
$1.00 | 1kg | 95%-99% | 100kg | Career Henan Chemical Co | |
|
|
2019-07-06 | AURINTRICARBOXYLIC ACID
4431-00-9
|
$1.00 | 1kg | 95%-99% | 100kg | Career Henan Chemical Co |
-
- Aurintricarboxylic acid
4431-00-9
- $30.00-61.00
- 85.00%
- TargetMol Chemicals Inc.
-
- AURINTRICARBOXYLIC ACID
4431-00-9
- $1.00
- 95%-99%
- Career Henan Chemical Co
-
- AURINTRICARBOXYLIC ACID
4431-00-9
- $1.00
- 95%-99%
- Career Henan Chemical Co
