2,4,6-Trichloropyridine
- CAS No.
- 16063-69-7
- Chemical Name:
- 2,4,6-Trichloropyridine
- Synonyms
- 2,4,6-trichloro-pyridin;2,4,6-Trichloropyridine;Pyridine,2,4,6-trichloro-;2 4 6-TRICHLOROPYRIDINE 97;2,4,6-Trichloropyridine,98%;2,4,6-Trichloropyridine ISO 9001：2015 REACH
- CBNumber:
- CB7498770
- Molecular Formula:
- C5H2Cl3N
- Molecular Weight:
- 182.44
- MDL Number:
- MFCD00971928
- MOL File:
- 16063-69-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 33-37 °C (lit.) |
|---|---|
| Boiling point | 217.5-218.5 °C |
| Density | 1.539±0.06 g/cm3(Predicted) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| pka | -2.93±0.10(Predicted) |
| form | Crystalline Powder |
| color | Yellow to yellow-brown |
| Water Solubility | Sparingly soluble in water. (0.113 mm Hg at 25°C) |
| InChI | InChI=1S/C5H2Cl3N/c6-3-1-4(7)9-5(8)2-3/h1-2H |
| InChIKey | FJNNGKMAGDPVIU-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(Cl)=CC(Cl)=C1 |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H317-H318 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 22-41-43 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UU0875000 | |||||||||
| HS Code | 29333990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Sens. 1 |
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| NFPA 704 |
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2,4,6-Trichloropyridine price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 633534 | 2,4,6-Trichloropyridine 97% | 16063-69-7 | 5g | $618 | 2026-04-30 | Buy |
| Sigma-Aldrich | 633534 | 2,4,6-Trichloropyridine 97% | 16063-69-7 | 1g | $230 | 2023-01-07 | Buy |
| TCI Chemical | T3395 | 2,4,6-Trichloropyridine min. 98.0 % | 16063-69-7 | 1G | $56 | 2026-04-30 | Buy |
| TCI Chemical | T3395 | 2,4,6-Trichloropyridine min. 98.0 % | 16063-69-7 | 5G | $192 | 2026-04-30 | Buy |
| ChemScene | CS-W002718 | 2,4,6-Trichloropyridine ≥96% | 16063-69-7 | 5g | $16 | 2026-06-04 | Buy |
2,4,6-Trichloropyridine Chemical Properties, Uses, Production
Chemical Properties
White to off-white crystals or crystalline solid
Uses
2,4,6-Trichloropyridine is used as pharmaceutical intermediates.
Synthesis
2587-00-0
16063-69-7
2,6-Dichloropyridine-N-oxide (Y-2) (8.20 g, 0.050 mol) was used as a raw material, which was dissolved in phosphorus trichloride (POCl3, 25 mL) and the reaction was carried out at reflux for 4 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was carefully poured into crushed ice and extracted with petroleum ether (3 x 50 mL). The organic phases were combined, dried with anhydrous potassium carbonate (K2CO3), filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography using a mixed solvent of ethyl acetate/petroleum ether as eluent, resulting in colorless needle-like crystals of 2,4,6-trichloropyridine (Y-3) in 85% yield with a melting point of 32-33 °C. The final product was extracted from the crude product using a mixture of ethyl acetate/petroleum ether as eluent, and then dried with anhydrous potassium carbonate (3 × 50 mL).
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 109, p. 294 - 304
[2] Patent: CN105294550, 2016, A. Location in patent: Paragraph 0045; 0048
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 8, p. 2051 - 2060
[4] Chemical & Pharmaceutical Bulletin, 1986, vol. 34, # 9, p. 3658 - 3671
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 40, p. 12321 - 12324
2,4,6-Trichloropyridine Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Pope Bio-tech R&D Co., Ltd | 025-87138562 18951783565 | sales@popebiotech.com | China | 414 | 58 |
| Zhengzhou TRIZ Pharmaceutical Technology Co., Ltd. | 19943855286 | 94644163@qq.com | China | 1934 | 56 |
| Hunan HuaTeng Pharmaceutical Co., Ltd., | 400-8592883 15367835770 | sales@huatengsci.com | China | 5869 | 58 |
| Shanghai Yaoke Biotechnology Co., Ltd | 19943855286 | wangyangguang@trizpharma.cn | China | 432 | 58 |
| Deyang haijungang Technology Co., Ltd | 15883665058 | dyhjgkj@126.com | China | 555 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
View Latest Price from 2,4,6-Trichloropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-16 | 2,4,6-Trichloropyridine
16063-69-7
|
1kg | 99 | Hangzhou Lucky Biology Co., Ltd | |||
 |
2026-09-02 | 2,4,6-Trichloropyridine
16063-69-7
|
$1.00-200.00 | 1KG | 99%, 99.5% Sublimated | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2,4,6-Trichloropyridine
16063-69-7
|
$1.10 | 1g | 99.00% | 100 Tons min | Dideu Industries Group Limited |
-
- 2,4,6-Trichloropyridine
16063-69-7
- $0.00
- 99
- Hangzhou Lucky Biology Co., Ltd
-
- 2,4,6-Trichloropyridine
16063-69-7
- $1.00-200.00
- 99%, 99.5% Sublimated
- Henan Fengda Chemical Co., Ltd
-
- 2,4,6-Trichloropyridine
16063-69-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
