NEDD8 inhibitor M22
- CAS No.
- 864420-54-2
- Chemical Name:
- NEDD8 inhibitor M22
- Synonyms
- NAE-IN-M22;NEDD8 inhibitor M22;M22 NEDD8 inhibitor;NAE-IN-M22, 10 mM in DMSO;NEDD8 inhibitor M22 ，S3400;1-Benzyl-N-[2-(2,4-dichlorophenyl)ethyl]piperidin-4-amine;N-[2-(2,4-Dichlorophenyl)ethyl]-1-(phenylmethyl)-4-piperidinamine;4-Piperidinamine, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-;NAEINM22,cancer,Inhibitor,NAE-IN-M-22,NAE,NEDD8,NAE IN M22,enzyme,activating,inhibit,tumor,Apoptosis
- CBNumber:
- CB75867548
- Molecular Formula:
- C20H24Cl2N2
- Molecular Weight:
- 363.32
- MDL Number:
- MFCD01453465
- MOL File:
- 864420-54-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
NEDD8 inhibitor M22 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 37756 | NEDD8 Inhibitor M22 ≥98% | 864420-54-2 | 500μg | $74 | 2026-04-30 | Buy |
| Cayman Chemical | 37756 | NEDD8 Inhibitor M22 ≥98% | 864420-54-2 | 1mg | $140 | 2026-04-30 | Buy |
| Cayman Chemical | 37756 | NEDD8 Inhibitor M22 ≥98% | 864420-54-2 | 5mg | $293 | 2026-04-30 | Buy |
| Cayman Chemical | 37756 | NEDD8 Inhibitor M22 ≥98% | 864420-54-2 | 10mg | $438 | 2026-04-30 | Buy |
| Biosynth | PJB42054 | 1-Benzyl-N-[2-(2,4-dichlorophenyl)ethyl]piperidin-4-amine | 864420-54-2 | 10mg | $540 | 2026-06-04 | Buy |
NEDD8 inhibitor M22 Chemical Properties, Uses, Production
Uses
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo[1].
in vivo
M22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts[1].
M22 (0.36-90 μM) has low acute toxicity in zebrafish model[1].
References
[1] Lu P, et, al. Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual Screening. ACS Chem Biol. 2016 Jul 15;11(7):1901-7. DOI:10.1021/acschembio.6b00159
NEDD8 inhibitor M22 Preparation Products And Raw materials
Raw materials
Preparation Products
NEDD8 inhibitor M22 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 17801761073 18101056239 | 3193328036@qq.com | China | 28150 | 68 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| Shandong Jirun Biomedical Technology Co., Ltd. | 0539-0539-8613587 17661611089 | 2639273505@qq.com | China | 237 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 | psaitong@jm-bio.com | China | 27626 | 58 |
View Latest Price from NEDD8 inhibitor M22 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-11 | NAE-IN-M22
864420-54-2
|
$93.00-339.00 | 98.67% | 10g | TargetMol Chemicals Inc. |
-
- NAE-IN-M22
864420-54-2
- $93.00-339.00
- 98.67%
- TargetMol Chemicals Inc.
