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NEDD8 inhibitor M22

NEDD8 inhibitor M22 Structure
NEDD8 inhibitor M22 structure
CAS No.
864420-54-2
Chemical Name:
NEDD8 inhibitor M22
Synonyms
NAE-IN-M22;NEDD8 inhibitor M22;M22 NEDD8 inhibitor;NAE-IN-M22, 10 mM in DMSO;NEDD8 inhibitor M22 ，S3400;1-Benzyl-N-[2-(2,4-dichlorophenyl)ethyl]piperidin-4-amine;4-Piperidinamine, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-;NAEINM22,cancer,Inhibitor,NAE-IN-M-22,NAE,NEDD8,NAE IN M22,enzyme,activating,inhibit,tumor,Apoptosis
CBNumber:
CB75867548
Molecular Formula:
C20H24Cl2N2
Molecular Weight:
363.32
MDL Number:
MFCD01453465
MOL File:
864420-54-2.mol
Last updated:2025-11-11 10:47:11
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NEDD8 inhibitor M22 Properties

storage temp. Store at -20°C
solubility DMSO: 250 mg/mL (688.10 mM)
form Solid
color White to off-white

NEDD8 inhibitor M22 Chemical Properties,Uses,Production

Uses

NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo[1].

in vivo

M22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts[1].
M22 (0.36-90 μM) has low acute toxicity in zebrafish model[1].

References

[1] Lu P, et, al. Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual Screening. ACS Chem Biol. 2016 Jul 15;11(7):1901-7. DOI:10.1021/acschembio.6b00159

NEDD8 inhibitor M22 Preparation Products And Raw materials

Raw materials

Preparation Products

NEDD8 inhibitor M22 Suppliers

Global( 37)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32435 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 39035 58
HANGZHOU LEAP CHEM CO., LTD. 		+86-571-87711850 market18@leapchem.com China 43339 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9803 58
Shanghai YuanYe Biotechnology Co., Ltd. 021-61312847; 18021002903 3008007409@qq.com China 71826 60
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720 klq@cw-bio.com China 7331 55
Beijing Solarbio Science & Tecnology Co., Ltd. 010-50973130 18101056239 3193328036@qq.com China 29760 68
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
TargetMol Chemicals Inc. 		58
InvivoChem 		58
TargetMol Chemicals Inc. 		58
HANGZHOU LEAP CHEM CO., LTD. 		58
Aladdin Scientific 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai YuanYe Biotechnology Co., Ltd. 60
Tianjin Kailiqi Biotechnology Co., Ltd. 55
Beijing Solarbio Science & Tecnology Co., Ltd. 68

View Lastest Price from NEDD8 inhibitor M22 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NAE-IN-M22 pictures 2025-11-10 NAE-IN-M22
864420-54-2
 US $93.00-339.00 / mg 98.67% 10g TargetMol Chemicals Inc.
  • NAE-IN-M22 pictures
  • NAE-IN-M22
    864420-54-2
  • US $93.00-339.00 / mg
  • 98.67%
  • TargetMol Chemicals Inc.

NEDD8 inhibitor M22 Spectrum

NEDD8 inhibitor M22(864420-54-2)1HNMR
NEDD8 inhibitor M22 4-Piperidinamine, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)- NAE-IN-M22 NAEINM22,cancer,Inhibitor,NAE-IN-M-22,NAE,NEDD8,NAE IN M22,enzyme,activating,inhibit,tumor,Apoptosis NAE-IN-M22, 10 mM in DMSO M22 NEDD8 inhibitor 1-Benzyl-N-[2-(2,4-dichlorophenyl)ethyl]piperidin-4-amine NEDD8 inhibitor M22 ，S3400 864420-54-2