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5-Bromo-1H-indazole-3-carboxylic acid

5-Bromo-1H-indazole-3-carboxylic acid structure

CAS No.: 1077-94-7

Chemical Name:: 5-Bromo-1H-indazole-3-carboxylic acid

Synonyms: 5-BROMOINDAZOLE-3-CARBOXYLIC ACID;5-BroMo-1H-indazole-3-car...;5-Bromo-3-carboxy-1H-indazole;5-BROMO-3-INDAZOLECARBOXYLIC ACID;5-broMo-1H-indazol-3-carboxylic acid;5-Bromo-1H-indazole-3-carboxylic acid;5-bromobenzopyrazole-3-carboxylic acid;1H-INDAZOLE-3-CARBOXYLIC ACID, 5-BROMO-

CBNumber:: CB7719134

Molecular Formula:: C8H5BrN2O2

Molecular Weight:: 241.04

MDL Number:: MFCD05663979

MOL File:: 1077-94-7.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:55:05

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5-Bromo-1H-indazole-3-carboxylic acid Properties

Melting point	289-292°C
Boiling point	493.4±25.0 °C(Predicted)
Density	1.946±0.06 g/cm3(Predicted)
storage temp.	2-8°C
form	solid
pka	2.81±0.30(Predicted)
color	Off-white
InChI	InChI=1S/C8H5BrN2O2/c9-4-1-2-6-5(3-4)7(8(12)13)11-10-6/h1-3H,(H,10,11)(H,12,13)
InChIKey	AMJVXOOGGBPVCZ-UHFFFAOYSA-N
SMILES	N1C2=C(C=C(Br)C=C2)C(C(O)=O)=N1
CAS DataBase Reference	1077-94-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H335-H319-H302+H312+H332

Precautionary statements

P271-P261-P280

Hazard Codes

Xi,Xn

Risk Statements

Safety Statements

22-26-36/37/39

Hazard Note

Irritant

HS Code

2933998090

NFPA 704

	1
2		0

5-Bromo-1H-indazole-3-carboxylic acid price More Price(69)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	266695	5-Bromo-1H-indazole-3-carboxylic acid Asreported	1077-94-7	500mg	$382	2026-06-03	Buy
Usbiological	266695	5-Bromo-1H-indazole-3-carboxylic acid Asreported	1077-94-7	1g	$674	2026-06-03	Buy
Usbiological	266695	5-Bromo-1H-indazole-3-carboxylic acid Asreported	1077-94-7	2g	$958	2026-06-03	Buy
Usbiological	266695	5-Bromo-1H-indazole-3-carboxylic acid Asreported	1077-94-7	5g	$1370	2026-06-03	Buy
Apolloscientific	OR14502	5-Bromo-1H-indazole-3-carboxylic acid 97%	1077-94-7	5g	$25	2026-06-04	Buy

Product number	Packaging	Price	Buy
266695	500mg	$382	Buy
266695	1g	$674	Buy
266695	2g	$958	Buy
266695	5g	$1370	Buy
OR14502	5g	$25	Buy

5-Bromo-1H-indazole-3-carboxylic acid Chemical Properties, Uses, Production

Uses

5-Bromo-1H-indazole-3-carboxylic acid an important chemical product. It is mainly used as a raw material in chemical synthesis for the preparation of other compounds. Its derivative 5-Bromo-1H-indazole-3-carboxylic acid ethyl ester can be used as a protein kinase inhibitor, which can be used for the treatment and prevention of diseases.

Synthesis

4498-67-3

1077-94-7

Step 1: Indazole-3-carboxylic acid (CXXXI) (1.0 g, 6.16 mmol) was suspended in glacial acetic acid (60 mL) and heated to 120 °C until a clear solution was formed. The solution was then cooled to 90 °C. A solution of bromine (0.633 mL, 12.33 mmol) in glacial acetic acid (2 mL) was slowly added dropwise to the solution at 90 °C. After addition, the reaction continued to be heated at 90 °C for 16 hours. After completion of the reaction, the solution was cooled to room temperature and poured into ice water and stirred at room temperature for 15 minutes. The precipitated solid was filtered, washed with cold water and dried under vacuum at room temperature to afford 5-bromo-1H-indazole-3-carboxylic acid (CXXXII) as a white solid (1.30 g, 5.39 mmol, 87.5% yield). The product was characterized by 1H NMR (DMSO-d6): δ 13.95 (s, 1H), 13.18 (br s, 1H), 8.21 (d, J = 1.2 Hz, 1H), 7.65 (d, J = 7.0 Hz, 1H), 7.56 (dd, J = 7.0, 1.2 Hz, 1H); ESIMS m/z 242.0 ([M + H]+. (calculated value C8H4BrN2O2).

References

[1] Patent: US2015/266825, 2015, A1. Location in patent: Paragraph 1359; 1360
[2] Patent: WO2018/75858, 2018, A1. Location in patent: Paragraph 0371; 0372
[3] Patent: CN107573327, 2018, A. Location in patent: Paragraph 0067; 0068; 0069; 0070
[4] Patent: US2005/90529, 2005, A1. Location in patent: Page/Page column 84-85
[5] Chemische Berichte, 1922, vol. 55, p. 1141,1157

5-Bromo-1H-indazole-3-carboxylic acid synthesis

Synthesis of 5-Bromo-1H-indazole-3-carboxylic acid from Indazole-3-carboxylic acid

5-Bromo-1H-indazole-3-carboxylic acid Preparation Products And Raw materials

Raw materials

5-Bromoisatin Indazole-3-carboxylic acid

Preparation Products

5-Bromo-1H-indazole-3-carbaldehyde Methyl 5-bromo-1H-indazole-3-carboxylate

5-Bromo-1H-indazole-3-carboxylic acid Suppliers

Global Suppliers ( 218)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Actchem Co,. Ltd,	+86-18762124502	actchem@qq.com	China	16	58
Hefei Qianhang Pharmaceutical Technology Co., Ltd.	13346199520	1356223173@qq.com	China	61	58
Shanghai Lingfu Pharmaceutical Research Co. LTD	+86(21)5895 0110 19945755304	sales@chemany.com	China	9981	58
Shandong Fengyang Technology Co., Ltd.	19285468033 19255465625	19255465625@163.com	China	40	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
ZEROSCHEM.CO.,LTD.	10-61256048 13810278579;	sales@zeroschem.com	China	1401	59

Supplier	Advantage
Suzhou Actchem Co,. Ltd,	58
Hefei Qianhang Pharmaceutical Technology Co., Ltd.	58
Shanghai Lingfu Pharmaceutical Research Co. LTD	58
Shandong Fengyang Technology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Capot Chemical Co., Ltd	66
Pure Chemistry Scientific Inc.	62
Accela ChemBio Co.,Ltd.	64
ZEROSCHEM.CO.,LTD.	59

View Latest Price from 5-Bromo-1H-indazole-3-carboxylic acid manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-07-20	5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID 1077-94-7	1kg	98%	1000kg	Shaanxi Dideu New Materials Co. Ltd
2025-12-24	5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID 1077-94-7	1KG	98.0%	10	Shaanxi Dideu Medichem Co. Ltd
2025-09-13	5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID 1077-94-7		98%	1000KGS	Zhengzhou Anbu Chem Co.,Ltd

5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID
1077-94-7
$0.00
98%
Shaanxi Dideu New Materials Co. Ltd

5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID
1077-94-7
$0.10
98.0%
Shaanxi Dideu Medichem Co. Ltd

5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID
1077-94-7
$0.00
98%
Zhengzhou Anbu Chem Co.,Ltd

5-Bromo-1H-indazole-3-carboxylic acid Spectrum

5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID(1077-94-7)¹HNMR

1077-94-7 (5-Bromo-1H-indazole-3-carboxylic acid) Related Search:

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1H-INDAZOLE-3-CARBOXYLIC ACID, 5-BROMO- 5-BROMO-3-INDAZOLECARBOXYLIC ACID 5-BroMo-1H-indazole-3-car... 5-Bromo-3-carboxy-1H-indazole 5-broMo-1H-indazol-3-carboxylic acid 5-bromobenzopyrazole-3-carboxylic acid 5-BROMOINDAZOLE-3-CARBOXYLIC ACID 5-Bromo-1H-indazole-3-carboxylic acid 1077-94-7 Indazole Building Blocks pharmacetical