Methyl 2-chloro-6-methylpyridine-4-carboxylate
- CAS No.
- 3998-90-1
- Chemical Name:
- Methyl 2-chloro-6-methylpyridine-4-carboxylate
- Synonyms
- METHYL 2-CHLORO-6-METHYLISONICOTINATE;ETHYL 2-CHLORO-6-METHYLISONICOTINATE;2-METHOXYL-5-NITROPICOLINE;Methyl 2-Chloro-6-methylisonicotite;2-Chloro-6-methyl methylisonicotinate;Methyl2-Chloro-6-methylisonicotinate>METHYL 2-CHLORO-6-METHYLPYRIDINE-4-CARB&;Methyl 2-chloro-6-picoline-4-carboxylate;Methyl 2-chloro-6-methylisonicotinate 97%;methyl 6-chloro-2-methylpyridine-4-carboxylate
- CBNumber:
- CB7724864
- Molecular Formula:
- C8H8ClNO2
- Molecular Weight:
- 185.61
- MDL Number:
- MFCD04038391
- MOL File:
- 3998-90-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 58-62 °C(lit.) |
|---|---|
| Boiling point | 124-125 °C7 mm Hg(lit.) |
| Density | 1.247±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | -0.19±0.10(Predicted) |
| color | White to Almost white |
| InChI | InChI=1S/C8H8ClNO2/c1-5-3-6(8(11)12-2)4-7(9)10-5/h3-4H,1-2H3 |
| InChIKey | BDWMGYZSQKGUFA-UHFFFAOYSA-N |
| SMILES | C1(Cl)=NC(C)=CC(C(OC)=O)=C1 |
| CAS DataBase Reference | 3998-90-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H315-H317-H318-H335 | |||||||||
| Precautionary statements | P280-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41-43 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Dam. 1 Skin Irrit. 2 Skin Sens. 1 STOT SE 3 |
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| NFPA 704 |
|
Methyl 2-chloro-6-methylpyridine-4-carboxylate price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 649481 | Methyl 2-chloro-6-methylpyridine-4-carboxylate 97% | 3998-90-1 | 1g | $44.4 | 2023-06-20 | Buy |
| Sigma-Aldrich | 649481 | Methyl 2-chloro-6-methylpyridine-4-carboxylate 97% | 3998-90-1 | 5g | $164 | 2023-06-20 | Buy |
| TCI Chemical | M2239 | Methyl 2-Chloro-6-methylisonicotinate >97.0%(GC) | 3998-90-1 | 1g | $26 | 2026-04-30 | Buy |
| TCI Chemical | M2239 | Methyl 2-Chloro-6-methylisonicotinate >97.0%(GC) | 3998-90-1 | 5g | $102 | 2026-04-30 | Buy |
| Usbiological | 284697 | Methyl 2-chloro-6-picoline-4-carboxylate Asreported | 3998-90-1 | 2g | $375 | 2026-06-03 | Buy |
Methyl 2-chloro-6-methylpyridine-4-carboxylate Chemical Properties, Uses, Production
Uses
Methyl 2-Chloro-6-methylisonicotinate is used in the synthesis of pyridine derivatives as antitubercular agents
Synthesis
67-56-1
25462-85-5
3998-90-1
General procedure: 2-chloro-6-methylpyridine-4-carboxylic acid (2.37 g, 15.5 mmol) was added to a stirred solution of phosphorus oxychloride (POCl3, 10 mL, 107 mmol) and heated to reflux for 18 hours. Upon completion of the reaction, excess POCl3 was removed by distillation under reduced pressure and the residue was cooled to -5°C. Methanol (20 mL) was slowly added dropwise and stirred for 24 h at room temperature. Subsequently, methanol was removed by complete distillation and the reaction mixture was neutralized with solid sodium bicarbonate (NaHCO3) and partitioned between water (30 mL) and ethyl acetate (EtOAc, 30 mL). The aqueous layer was extracted with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by rapid chromatography on silica gel (eluent: dichloromethane, CH2Cl2) to afford methyl 2-chloro-6-methyl-isonicotinate (2 g, 10.8 mmol, 69% yield) as a white solid. Thin layer chromatography (TLC, silica gel plate, dichloromethane as unfolding agent) Rf value was 0.66. Nuclear magnetic resonance hydrogen spectrum (1H NMR, 300 MHz, CDCl3) δ 2.59 (s, 3H), 3.94 (s, 3H), 7.61 (s, 1H), 7.67 (s, 1H); nuclear magnetic resonance carbon spectrum (13C NMR, 75 MHz, CDCl3) δ 24.2, 52.9, 120.8, 121.2, 140.3, 151.4, 160.5, 164.6; mass spectrum (MS, EI, 70 eV): m/z (relative abundance) [M+H]+ 186 (100).
References
[1] Tetrahedron Letters, 2007, vol. 48, # 6, p. 999 - 1002
[2] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 14, p. 4629 - 4635
[3] Chemistry - A European Journal, 2015, vol. 21, # 33, p. 11745 - 11756
Methyl 2-chloro-6-methylpyridine-4-carboxylate Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Focus Pharmaceutical Technology Co., Ltd. | 028-64950838 17340131597 | wangmin@focuspharm.com | China | 750 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
View Latest Price from Methyl 2-chloro-6-methylpyridine-4-carboxylate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Methyl 2-chloro-6-methylpyridine-4-carboxylate
3998-90-1
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2025-04-04 | Methyl 2-chloro-6-methylpyridine-4-carboxylate
3998-90-1
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
 |
2021-07-13 | Methyl 2-chloro-6-methylpyridine-4-carboxylate
3998-90-1
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Methyl 2-chloro-6-methylpyridine-4-carboxylate
3998-90-1
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- Methyl 2-chloro-6-methylpyridine-4-carboxylate
3998-90-1
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- Methyl 2-chloro-6-methylpyridine-4-carboxylate
3998-90-1
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
