Indole-2-carboxylic acid
- CAS No.
- 1477-50-5
- Chemical Name:
- Indole-2-carboxylic acid
- Synonyms
- 1H-INDOLE-2-CARBOXYLIC ACID;2-INDOLECARBOXYLIC ACID;2-CARBOXYINDOLE;Indole-2-carboxylic;NSC 16598;e-2-carboxyL;AKOS JY2082713;Indol-2-carbonsure;2-Carboxy-1H-indole;TIMTEC-BB SBB003953
- CBNumber:
- CB7728231
- Molecular Formula:
- C9H7NO2
- Molecular Weight:
- 161.16
- MDL Number:
- MFCD00005611
- MOL File:
- 1477-50-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 202-206 °C(lit.) |
|---|---|
| Boiling point | 287.44°C (rough estimate) |
| Density | 1.2480 (rough estimate) |
| refractive index | 1.5050 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Soluble in clear yellow solution 5% in ethanol, dimethyl sulfoxide and methanol. |
| pka | 4.44±0.30(Predicted) |
| form | Crystalline Powder or Crystals |
| color | Off-white to yellow to brown |
| BRN | 124132 |
| InChI | InChI=1S/C9H7NO2/c11-9(12)8-5-6-3-1-2-4-7(6)10-8/h1-5,10H,(H,11,12) |
| InChIKey | HCUARRIEZVDMPT-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2)C=C1C(O)=O |
| CAS DataBase Reference | 1477-50-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| NIST Chemistry Reference | Indole-2-carboxylic acid(1477-50-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H301-H311-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P310a-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-21/22 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NK7882812 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Indole-2-carboxylic acid price More Price(100)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I5109 | Indole-2-carboxylic acid 98% | 1477-50-5 | 5g | $123 | 2026-04-30 | Buy |
| Sigma-Aldrich | I5109 | Indole-2-carboxylic acid 98% | 1477-50-5 | 10g | $124 | 2026-04-30 | Buy |
| TCI Chemical | I0332 | Indole-2-carboxylic Acid >98.0%(GC)(T) | 1477-50-5 | 5g | $20 | 2026-04-30 | Buy |
| TCI Chemical | I0332 | Indole-2-carboxylic Acid >98.0%(GC)(T) | 1477-50-5 | 25g | $37 | 2026-04-30 | Buy |
| Usbiological | I0797-78 | Indole-2-carboxylic Acid | 25g | $439 | 2026-06-03 | Buy |
Indole-2-carboxylic acid Chemical Properties, Uses, Production
Chemical Properties
Yellow Crystalline Powder
Uses
• ;Reactant for total synthesis of (±)-dibromophakellin and analogs1• ;Reactant for synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine2• ;Reactant for stereoselective preparation of renieramycin G analogs3• ;Reactant for preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization4• ;Reactant for Pd-catalyzed cyclization5• ;Reactant for preparation of N,N′-(pentane)diylbis[indolecarboxamide] and N,N′-[phenylenebis(
Uses
Reactant for total synthesis of (±)-dibromophakellin and analogs, synthesis of the pyrrolizidine alkaloid (±)-trachelanthamidine, stereo selective preparation of renieramycin G analogs, preparation of spirooxoindolepyrrolidines via reduction of indole-2-carboxylic acid followed by oxidation, condensation, reduction, amidation and Kharasch radical cyclization, Pd-catalyzed cyclization and N,N-(pentane)diylbis[indolecarboxamide] and N,N-[phenylenebis(methylene)]bis[indolecarboxamide] derivatives.
Definition
ChEBI: Indole-2-carboxylic acid is an indolyl carboxylic acid.
Synthesis Reference(s)
Tetrahedron Letters, 33, p. 7961, 1992 DOI: 10.1016/S0040-4039(00)74789-7
Synthesis
Indole-2-carboxylic acid is prepared by a two-step condensation–reductive cyclization route: starting from 1-methyl-2-nitrobenzene (1) and diethyl oxalate (2), the intermediate sodium salt of 3-(2-nitrophenyl)-2-oxopropanoic acid (3) is first obtained by condensation, which is then reduced and cyclized to give the target product indole-2-carboxylic acid (4) [1].
IC 50
NMDA Receptor; Human Endogenous Metabolite
References
[1] Jiang, T., Liu, N., Jiang, Y.-W., Ye, P.-P., Xu, W.-M. (2017). A Practical Synthesis of Indole-2-carboxylic Acid. Organic Preparations and Procedures International, 49(5), 476–478. https://doi.org/10.1080/00304948.2017.1374138
Indole-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Hunan Daolin Biotechnology Co. , Ltd. | 18974846212 | 1876969603@qq.com | China | 57 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 45000 | 61 |
| Beijing Mediking Biopharm Co., Ltd | 010-81769521,89753524,81760121 15901403431 | sales01@mediking.cn | China | 100 | 68 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from Indole-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-14 | Indole-2-carboxylic acid
1477-50-5
|
1KG | 98%min | 10 ton | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-09-02 | Indole-2-carboxylic acid
1477-50-5
|
$1.00-122.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-05-28 | Indole-2-carboxylic acid
1477-50-5
|
$2.00-5.00 | 1KG | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Indole-2-carboxylic acid
1477-50-5
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Indole-2-carboxylic acid
1477-50-5
- $1.00-122.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Indole-2-carboxylic acid
1477-50-5
- $2.00-5.00
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
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