ChemicalBook >> CAS DataBase List >>2H-1,3-Benzoxazine-2,4(3H)-dione

2H-1,3-Benzoxazine-2,4(3H)-dione

2H-1,3-Benzoxazine-2,4(3H)-dione structure

CAS No.: 2037-95-8

Chemical Name:: 2H-1,3-Benzoxazine-2,4(3H)-dione

Synonyms: carsalam;2H-Benzo[e][1,3]oxazine-2,4(3H)-dione;ruhmal;Casalen;Caxaran;Kasaron;beaprine;Cacharon;Carsalame;Two ketone

CBNumber:: CB7736467

Molecular Formula:: C8H5NO3

Molecular Weight:: 163.13

MDL Number:: MFCD00600566

MOL File:: 2037-95-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:09:29

Request For Quotation

2H-1,3-Benzoxazine-2,4(3H)-dione Properties

Melting point	228-232 °C(lit.)
Density	1.402±0.06 g/cm3(Predicted)
vapor pressure	0.73-1.27Pa at 89.94-107.94℃
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO : ≥ 40 mg/mL (245.20 mM)
form	Solid
pka	9.16±0.20(Predicted)
color	White to off-white
Merck	13,1879
InChI	InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)12-8(11)9-7/h1-4H,(H,9,10,11)
InChIKey	OAYRYNVEFFWSHK-UHFFFAOYSA-N
SMILES	O1C2=CC=CC=C2C(=O)NC1=O
LogP	0.78-0.88 at 20℃
FDA UNII	685H843ULU
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
WGK Germany	3
RTECS	DM3110000
HS Code	2934999090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral
REACH Registrations	Active

2H-1,3-Benzoxazine-2,4(3H)-dione price More Price(52)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B6742	2H-Benzo[e][1,3]oxazine-2,4(3H)-dione	2037-95-8	25G	$64	2026-04-30	Buy
TCI Chemical	B6742	2H-Benzo[e][1,3]oxazine-2,4(3H)-dione	2037-95-8	100G	$189	2026-04-30	Buy
Biosynth	FB45734	2H-1,3-Benzoxazine-2,4(3H)-dione	2037-95-8	0.25kg	$171.88	2026-06-04	Buy
ChemScene	CS-4568	Carsalam ≥97%	2037-95-8	25g	$34	2026-06-04	Buy
ChemScene	CS-4568	Carsalam ≥97%	2037-95-8	100g	$91	2026-06-04	Buy

Product number	Packaging	Price	Buy
B6742	25G	$64	Buy
B6742	100G	$189	Buy
FB45734	0.25kg	$171.88	Buy
CS-4568	25g	$34	Buy
CS-4568	100g	$91	Buy

2H-1,3-Benzoxazine-2,4(3H)-dione Chemical Properties, Uses, Production

Chemical Properties

Off-white to light brown crystalline powder

Uses

analgesic

Definition

ChEBI: Carsalam is a benzoxazine.

General Description

Kinetic studies of the alkaline hydrolysis of 2H-1,3-benzoxazine-2,4(3H)-dione (carsalam) were conducted and reaction was found to be of fractional order with respect to [OH^-].

Synthesis

2H-1,3-Benzoxazine-2,4(3H)-dione was prepared according to the procedure of Hoback, Crum and Carroll. To a solution of 411 g. (3. 0 moles) salicylamide in 483 ml. (6.0 moles) of anhydrous pyridine at 0℃ was added slowly with stirring 572 ml. (6.0 moles) of ethyl chlorocarbonate. The resulting orange solution was refluxed for 5 hr. and poured into 2L of ice water. The filtered product was washed twice with 0.5L of water and recrystallized three times from acetone-ethanol (50: 50), giving white needles 2H-1,3-Benzoxazine-2,4(3H)-dione (83% yield), m.p. 227.5-228.5° (lit. 12), m.p. 227-228°, which gave no coloration with ethanolic ferric chloride[1].

References

[1] J. D. Crum, J. A. Franks Jr. “The chemistry of heterocycles. III. 2H-1,3-benzoxazine-2,4(3H)-dione and Some 3-substituted derivatives..” Journal of Heterocyclic Chemistry 2 1 (1965): 37–40.

2H-1,3-Benzoxazine-2,4(3H)-dione synthesis

Synthesis of 2H-1,3-Benzoxazine-2,4(3H)-dione from 1,1'-Carbonyldiimidazole and Salicylamide

2H-1,3-Benzoxazine-2,4(3H)-dione Preparation Products And Raw materials

Raw materials

2H-1,3-Benzoxazin-2-one, 4-[(4-methylphenyl)amino]- Ethyl chloroformate carbon monoxide 2-Iodophenol 1,1'-Carbonyldiimidazole

Diethyl carbonate Salicylamide Phosgene Potassium cyanate Oxalyl chloride

1of2

Preparation Products

2H-1,3-Benzoxazine-2,4(3H)-dione Suppliers

Global Suppliers ( 265)

Supplier	Tel	Email	Country	ProdList	Advantage
Gansu Haotian PharmaTech Co.,Ltd.	17789447501	zhuanxiajiang@haotianpharm.com	China	211	58
Anhui Beirui Pharmaceutical Technology Co., Ltd	0551-68665055 18130089676	ahbrchem@163.com	China	18	58
Hangzhou Read Chemical Co., Ltd	15306818081	sales@freemindpharm.com	China	50	58
Abydos Scientific	18936879710 18851749494	sales@abydoscientific.com	China	1000	58
Nanjing Lynsci Chemical Co., Ltd	+86-025-83208253 +86-13851694729	layefe@163.com	China	234	62
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
XiaoGan ShenYuan ChemPharm co,ltd	15527621225; 15527621225	1791901229@qq.com	China	6742	52

Supplier	Advantage
Gansu Haotian PharmaTech Co.,Ltd.	58
Anhui Beirui Pharmaceutical Technology Co., Ltd	58
Hangzhou Read Chemical Co., Ltd	58
Abydos Scientific	58
Nanjing Lynsci Chemical Co., Ltd	62
Energy Chemical	61
Jia Xing Isenchem Co.,Ltd	66
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
XiaoGan ShenYuan ChemPharm co,ltd	52

View Latest Price from 2H-1,3-Benzoxazine-2,4(3H)-dione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-06-30	2H-1,3-Benzoxazine-2,4(3H)-dione 2037-95-8		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd
2026-06-08	2H-1,3-Benzoxazine-2,4(3H)-dione 2037-95-8		1kg	99%	1	Jinan Ruitong Biotech Co., Ltd.
2026-05-11	Carsalam 2037-95-8	$29.00		99.84%	10g	TargetMol Chemicals Inc.

2H-1,3-Benzoxazine-2,4(3H)-dione
2037-95-8
98.0%
Shaanxi Dideu New Materials Co. Ltd

2H-1,3-Benzoxazine-2,4(3H)-dione
2037-95-8
99%
Jinan Ruitong Biotech Co., Ltd.

Carsalam
2037-95-8
$29.00
99.84%
TargetMol Chemicals Inc.

2H-1,3-Benzoxazine-2,4(3H)-dione Spectrum

2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE(2037-95-8)¹HNMR 2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE(2037-95-8)IR1 2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE(2037-95-8)IR2

2037-95-8 (2H-1,3-Benzoxazine-2,4(3H)-dione) Related Search:

Isatoic Anhydride 6-Chloro-2H-3,1-benzoxazine-2,4(1H)-dione,6-Chloro-4H-3,1-benzoxazine-2(1H),4-dione,6-chloro-4h-3,1-benzoxazine-2,4(1h)-dione N-methylisatoic anhydride 3-[2-(Diethylamino)ethyl]-2H-1,3-benzoxazine-2,4(3H)-dione 6-chloro-1-methyl-2H-3,1-benzoxazine-2,4(1H)-dione

2H-1,3-Benzoxazine-2,4(3H)-dione 7-Methoxy-1,3-benzoxazine-2,4-dione 7-Methyl-2H-1,3-benzoxazine-2,4(3H)-dione 8-Hydroxy-2H-1,3-benzoxazine-2,4(3H)-dione 3-Methyl-2H-1,3-benzoxazine-2,4(3H)-dione

1-methyl-6-nitro-2H-3,1-benzoxazine-2,4(1H)-dione 3,5-Dichloroisatoic anhydride 5-Fluoro-2H-3,1-benzoxazine-2,4(1H)-dione 5-Nitroisatoic anhydride, tech. 6-Chloro-2H-1,4-benzoxazine-2,3(4H)-dione 3-oxime

6-Methyl-2H-1,4-benzoxazine-2,3(4H)-dione 3-oxime 2H-1,4-Benzoxazine-2,3(4H)-dione 3-oxime N-Benzylisatoic anhydride

1of4

beaprine oxophenhydroxazine ruhmal TIMTEC-BB SBB003929 1,3-BENZOXAZINE-2,4-DIONE 2H-1,3-Benzoxazine-2,4(3H)-dione 98% CAS:2037-95-8 Carsalam≥ 99% (HPLC) Two ketone 2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE 1,3-Benzoxazine-2,4-(3H)-dione Carsalame Carbonylsalicylamide 1,3-benzoxazine-2,4-quinone CarsalaM (1,3-benzoxazine-2,4-(3H)-dione) 2,4-Dioxo-3,4-dihydro-2H-1,3-benzoxazine 3,4-dihydro-2H-1,3-benzoxazine-2,4-dione 2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE ISO 9001：2015 REACH 3-BENZOXAZINE-2 4(3 H)-DIONE Carsalam(Carbonyl salicylamide) Kasharin reference substance Salcaprozate Impurity 9 Cacharon 8- (2-hydroxybenzamide) sodium octanoate impurity 22 Carsalam, 10 mM in DMSO 2H-1,3-Benzoxazine-2,4(3H)-dione Casalen Caxaran Oxolinicdiketone Kasaron 2H-1,3-benzenebenzoazine-2,4(3H)-dione 2H-1,3-Benzoxazine-2,4(3H)-dione(Carsalam) 2H-Benzo[e][1,3]oxazine-2,4(3H)-dione carsalam 2037-95-8 2307-95-8 2037-65-8 Building Blocks Benzoxazines Heterocyclic Building Blocks Benzoxazines Building Blocks Heterocyclic Building Blocks