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2H-1,3-Benzoxazine-2,4(3H)-dione

2H-1,3-Benzoxazine-2,4(3H)-dione structure

CAS No.: 2037-95-8

Chemical Name:: 2H-1,3-Benzoxazine-2,4(3H)-dione

Synonyms: carsalam;ruhmal;Casalen;Caxaran;Kasaron;beaprine;Cacharon;Carsalame;Two ketone;4(3 H)-DIONE

CBNumber:: CB7736467

Molecular Formula:: C8H5NO3

Molecular Weight:: 163.13

MDL Number:: MFCD00600566

MOL File:: 2037-95-8.mol

MSDS File:: SDS

Last updated:2026-04-16 17:44:27

Product description	Number	Pack Size	Price
2H-Benzo[e][1,3]oxazine-2,4(3H)-dione	B6742	25G	$64
2H-Benzo[e][1,3]oxazine-2,4(3H)-dione	B6742	100G	$189
Carsalam	C184748	10g	$85
Carsalam	C6933	200mg	$85
2H-Benzo[e][1,3]oxazine-2,4(3H)-dione 95%	OR941085	25g	$90
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2H-1,3-Benzoxazine-2,4(3H)-dione Properties

Melting point	228-232 °C(lit.)
Density	1.402±0.06 g/cm3(Predicted)
vapor pressure	0.73-1.27Pa at 89.94-107.94℃
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO : ≥ 40 mg/mL (245.20 mM)
pka	9.16±0.20(Predicted)
form	Solid
color	White to off-white
Merck	13,1879
InChI	InChI=1S/C8H5NO3/c10-7-5-3-1-2-4-6(5)12-8(11)9-7/h1-4H,(H,9,10,11)
InChIKey	OAYRYNVEFFWSHK-UHFFFAOYSA-N
SMILES	O1C2=CC=CC=C2C(=O)NC1=O
LogP	0.78-0.88 at 20℃
FDA UNII	685H843ULU
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
PPE	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xn
Risk Statements	22
Safety Statements	36
WGK Germany	3
RTECS	DM3110000
HS Code	2934999090
Storage Class	11 - Combustible Solids
Hazard Classifications	Acute Tox. 4 Oral

2H-1,3-Benzoxazine-2,4(3H)-dione price More Price(25)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	B6742	2H-Benzo[e][1,3]oxazine-2,4(3H)-dione	2037-95-8	25G	$64	2026-03-19	Buy
TCI Chemical	B6742	2H-Benzo[e][1,3]oxazine-2,4(3H)-dione	2037-95-8	100G	$189	2026-03-19	Buy
TRC	C184748	Carsalam	2037-95-8	10g	$85	2021-12-16	Buy
ApexBio Technology	C6933	Carsalam	2037-95-8	200mg	$85	2021-12-16	Buy
Apolloscientific	OR941085	2H-Benzo[e][1,3]oxazine-2,4(3H)-dione 95%	2037-95-8	25g	$90	2021-12-16	Buy

Product number	Packaging	Price	Buy
B6742	25G	$64	Buy
B6742	100G	$189	Buy
C184748	10g	$85	Buy
C6933	200mg	$85	Buy
OR941085	25g	$90	Buy

2H-1,3-Benzoxazine-2,4(3H)-dione Chemical Properties,Uses,Production

Chemical Properties

Off-white to light brown crystalline powder

Uses

analgesic

Definition

ChEBI: Carsalam is a benzoxazine.

General Description

Kinetic studies of the alkaline hydrolysis of 2H-1,3-benzoxazine-2,4(3H)-dione (carsalam) were conducted and reaction was found to be of fractional order with respect to [OH^-].

Synthesis

2H-1,3-Benzoxazine-2,4(3H)-dione was prepared according to the procedure of Hoback, Crum and Carroll. To a solution of 411 g. (3. 0 moles) salicylamide in 483 ml. (6.0 moles) of anhydrous pyridine at 0℃ was added slowly with stirring 572 ml. (6.0 moles) of ethyl chlorocarbonate. The resulting orange solution was refluxed for 5 hr. and poured into 2L of ice water. The filtered product was washed twice with 0.5L of water and recrystallized three times from acetone-ethanol (50: 50), giving white needles 2H-1,3-Benzoxazine-2,4(3H)-dione (83% yield), m.p. 227.5-228.5° (lit. 12), m.p. 227-228°, which gave no coloration with ethanolic ferric chloride[1].

References

[1] J. D. Crum, J. A. Franks Jr. “The chemistry of heterocycles. III. 2H-1,3-benzoxazine-2,4(3H)-dione and Some 3-substituted derivatives..” Journal of Heterocyclic Chemistry 2 1 (1965): 37–40.

2H-1,3-Benzoxazine-2,4(3H)-dione synthesis

Synthesis of 2H-1,3-Benzoxazine-2,4(3H)-dione from 1,1'-Carbonyldiimidazole and Salicylamide

2H-1,3-Benzoxazine-2,4(3H)-dione Preparation Products And Raw materials

Raw materials

2H-1,3-Benzoxazin-2-one, 4-[(4-methylphenyl)amino]- Ethyl chloroformate carbon monoxide 2-Iodophenol 1,1'-Carbonyldiimidazole

Diethyl carbonate Salicylamide PHOSGENE Potassium cyanate Oxalyl chloride

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Preparation Products

2H-1,3-Benzoxazine-2,4(3H)-dione Suppliers

Global( 256)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
CHANGZHOU HARVECHEM LTD	+86-0519-88784888 +8613906120163	inquiry@harvechem.com	China	311	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Hebei shuoxi biotechnology co. LTD	+8613081092107		CHINA	964	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9636	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	9548	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
CHANGZHOU HARVECHEM LTD	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
Hebei shuoxi biotechnology co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
Antai Fine Chemical Technology Co.,Limited	58
Zhengzhou Alfa Chemical Co.,Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from 2H-1,3-Benzoxazine-2,4(3H)-dione manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-16	Carsalam 2037-95-8	US $29.00 / mL		99.84%	10g	TargetMol Chemicals Inc.
2026-04-16	Carsalam 2037-95-8	US $29.00 / mL		99.84%	10g	TargetMol Chemicals Inc.
2025-12-01	2H-1,3-Benzoxazine-2,4(3H)-dione 2037-95-8	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

Carsalam
2037-95-8
US $29.00 / mL
99.84%
TargetMol Chemicals Inc.

Carsalam
2037-95-8
US $29.00 / mL
99.84%
TargetMol Chemicals Inc.

2H-1,3-Benzoxazine-2,4(3H)-dione
2037-95-8
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

2H-1,3-Benzoxazine-2,4(3H)-dione Spectrum

2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE(2037-95-8)¹HNMR 2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE(2037-95-8)IR1 2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE(2037-95-8)IR2

2037-95-8(2H-1,3-Benzoxazine-2,4(3H)-dione)Related Search:

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beaprine oxophenhydroxazine ruhmal TIMTEC-BB SBB003929 1,3-BENZOXAZINE-2,4-DIONE 2H-1,3-Benzoxazine-2,4(3H)-dione 98% CAS:2037-95-8 Carsalam≥ 99% (HPLC) Two ketone 2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE 1,3-Benzoxazine-2,4-(3H)-dione Carsalame Carbonylsalicylamide 1,3-benzoxazine-2,4-quinone 2H-Benzo[e][1,3]oxazine-2,4(3H)-dione CarsalaM (1,3-benzoxazine-2,4-(3H)-dione) 2,4-Dioxo-3,4-dihydro-2H-1,3-benzoxazine 3,4-dihydro-2H-1,3-benzoxazine-2,4-dione 2 H-1,3-BENZOXAZINE-2,4(3 H)-DIONE ISO 9001：2015 REACH 3-BENZOXAZINE-2 4(3 H)-DIONE Carsalam(Carbonyl salicylamide) Kasharin reference substance Salcaprozate Impurity 9 Cacharon 8- (2-hydroxybenzamide) sodium octanoate impurity 22 Carsalam, 10 mM in DMSO 2H-1,3-Benzoxazine-2,4(3H)-dione Casalen Caxaran Oxolinicdiketone Kasaron 2H-1,3-benzenebenzoazine-2,4(3H)-dione carsalam 2H-1,3-Benzoxazine-2,4(3H)-dione(Carsalam) 2037-95-8 2307-95-8 2037-65-8 Building Blocks Benzoxazines Heterocyclic Building Blocks Benzoxazines Building Blocks Heterocyclic Building Blocks