2'-Fluoroacetanilide
- CAS No.
- 399-31-5
- Chemical Name:
- 2'-Fluoroacetanilide
- Synonyms
- 2-FLUOROACETANILIDE;N-(2-FLUOROPHENYL)ACETAMIDE;Compound Fr14450;2-FLUOROACETANILINE;O-FLUOROACETANILIDE;2'-Fluoroacetanilide;2'-Fluoroacetanilide>Flurbiprofen Impurity 23;N-Acetyl 2-fluoroaniline;2-Fluorophenyl acetamide
- CBNumber:
- CB7776328
- Molecular Formula:
- C8H8FNO
- Molecular Weight:
- 153.15
- MDL Number:
- MFCD00000315
- MOL File:
- 399-31-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 77-79 °C(lit.) |
|---|---|
| Boiling point | 140-142 °C14 mm Hg(lit.) |
| Density | 1.1655 (estimate) |
| Flash point | 140-142°C/14mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 14.04±0.70(Predicted) |
| form | Fine Crystalline Powder |
| color | White |
| BRN | 2717443 |
| CAS DataBase Reference | 399-31-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetamide, N-(2-fluorophenyl)-(399-31-5) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37/39-36 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29242998 | |||||||||
| NFPA 704 |
|
2'-Fluoroacetanilide price More Price(34)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | F0524 | 2'-Fluoroacetanilide >98.0%(GC) | 399-31-5 | 25g | $126 | 2026-04-30 | Buy |
| Biosynth | FF70963 | 2-Fluoroacetanilide | 399-31-5 | 50g | $150 | 2026-06-04 | Buy |
| Biosynth | FF70963 | 2-Fluoroacetanilide | 399-31-5 | 500g | $150 | 2026-06-04 | Buy |
| Biosynth | FF70963 | 2-Fluoroacetanilide | 399-31-5 | 250g | $150 | 2026-06-04 | Buy |
| Biosynth | FF70963 | 2-Fluoroacetanilide | 399-31-5 | 100g | $150 | 2026-06-04 | Buy |
2'-Fluoroacetanilide Chemical Properties,Uses,Production
Chemical Properties
white fine crystalline powder
Uses
2''-Fluoroacetanilide
Synthesis
348-54-9
108-24-7
399-31-5
Step 1: Synthesis of N-(2-fluorophenyl)acetamide To a solution of 2-fluoroaniline (5.0 g, 45.05 mmol) in dichloromethane (DCM, 225 mL) was sequentially added acetic anhydride (4.09 mL, 45.05 mmol) and triethylamine (7.55 mL, 54.05 mmol). The reaction mixture was stirred at room temperature for 6 hours. After completion of the reaction, the mixture was concentrated, diluted with ethyl acetate and washed with 1N hydrochloric acid (2 x 50 mL). The organic phase was dried with anhydrous sodium sulfate (Na2SO4) and concentrated to give N-(2-fluorophenyl)acetamide (6.20 g, 90% yield) as a white solid.LCMS analysis showed the molecular ion peak of the target product to be 153.99 (M + H)+.
References
[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 11, p. 2187 - 2196
[2] Patent: US2008/139558, 2008, A1. Location in patent: Page/Page column 80
[3] Journal of the Chemical Society - Perkin Transactions 1, 1996, # 7, p. 669 - 673
[4] Patent: US2012/238543, 2012, A1. Location in patent: Page/Page column 13
[5] Patent: US2012/270854, 2012, A1. Location in patent: Page/Page column 20
2'-Fluoroacetanilide Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Maya High Purity Chemicals | +86 (573) 82222445 (0)18006601000 452520369 | sales@maya-r.com | China | 11693 | 57 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9336 | 55 |
