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Thalidomide-O-PEG4-Propargyl

Thalidomide-O-PEG4-Propargyl Structure
Thalidomide-O-PEG4-Propargyl structure
CAS No.
2098799-77-8
Chemical Name:
Thalidomide-O-PEG4-Propargyl
Synonyms
Thalidomide-PEG4-Propargyl;Thalidomide-O-PEG4-Propargyl;Thalidomide-4-PEG4-O-Propargyl;4-((3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;2-(2,6-Dioxo-3-piperidinyl)-4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)-1H-isoindole-1,3(2H)-dione;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)-;E3 Ligase Ligand-Linker Conjugates,Thalidomide-PEG-4-Propargyl,inhibit,Inhibitor,Thalidomide PEG4 Propargyl,ThalidomidePEG4Propargyl
CBNumber:
CB78184545
Molecular Formula:
C24H28N2O9
Molecular Weight:
488.49
MDL Number:
MFCD32207014
MOL File:
2098799-77-8.mol
MSDS File:
SDS
Last updated:2026-09-10 08:17:50
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Thalidomide-O-PEG4-Propargyl Properties

Boiling point 673.9±55.0 °C(Predicted)
Density 1.320±0.06 g/cm3(Predicted)
storage temp. -20°C, stored under nitrogen
solubility Soluble in Water, DMF, DCM, DMSO
pka 10.70±0.40(Predicted)
form Solid
color White to light yellow

SAFETY

Risk and Safety Statements

HS Code  2933998090

Thalidomide-O-PEG4-Propargyl price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0114303 Thalidomide-PEG4-Propargyl ≥98% 2098799-77-8 50mg $135 2026-06-04 Buy
ChemScene CS-0114303 Thalidomide-PEG4-Propargyl ≥98% 2098799-77-8 100mg $245 2026-06-04 Buy
ChemScene CS-0114303 Thalidomide-PEG4-Propargyl ≥98% 2098799-77-8 250mg $574 2026-06-04 Buy
ChemScene CS-0114303 Thalidomide-PEG4-Propargyl ≥98% 2098799-77-8 1g $1756 2026-06-04 Buy
Apolloscientific BIPC1007 Thalidomide-O-PEG4-Propargyl 2098799-77-8 100mg $1131 2026-06-04 Buy
Product number Packaging Price Buy
CS-0114303 50mg $135 Buy
CS-0114303 100mg $245 Buy
CS-0114303 250mg $574 Buy
CS-0114303 1g $1756 Buy
BIPC1007 100mg $1131 Buy

Thalidomide-O-PEG4-Propargyl Chemical Properties, Uses, Production

Description

Thalidomide-O-PEG4-Propargyl is synthesized compound that incorporates the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology, Propargyl is reactive with azide molecule in the presence of Cu catalyst.

Uses

Thalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

Cereblon

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-998. DOI:10.1016/j.str.2020.07.015

Thalidomide-O-PEG4-Propargyl Preparation Products And Raw materials

Raw materials

Preparation Products

Thalidomide-O-PEG4-Propargyl Suppliers

Global Suppliers ( 29)
Supplier Tel Email Country ProdList Advantage
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7909 65
Dtchem Laboratories,（Gan Su）Co.,Ltd. 18993961550 18993966060 sales@techbiochem.com China 774 61
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4229 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 025-86755008 17751752005 hszhang@bestfluorodrug.com China 2357 58
Shandong Territorial sea Biological Technology Co., LTD 15092083467 tangfenjiushililiang@leadhigh.com.cn China 2986 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 043180534350 19917294565 et@chemextension.com China 4445 58
Zhengzhou Akem Chemical Co., Ltd 13303867194 770406999@qq.com China 9949 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 59929 58
Supplier Advantage
Daicel Chiral Technologies (China)CO.,LTD 65
Dtchem Laboratories,（Gan Su）Co.,Ltd. 61
Xi'an Confluore Biological Technology Co., Ltd. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Nanjing Bestfluorodrug Pharmaceutical Technology CO.,LTD 58
Shandong Territorial sea Biological Technology Co., LTD 58
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd 58
Zhengzhou Akem Chemical Co., Ltd 58
Bide Pharmatech Ltd. 58

View Latest Price from Thalidomide-O-PEG4-Propargyl manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Thalidomide-PEG4-Propargyl pictures 2026-09-10 Thalidomide-PEG4-Propargyl
2098799-77-8
 $40.00-92.00 99.98% 10g TargetMol Chemicals Inc.
Thalidomide-O-PEG4-Propargyl pictures 2025-06-07 Thalidomide-O-PEG4-Propargyl
2098799-77-8
 100mg >95.00% 100mg Xian confluore Biological Technology Co., Ltd.

Thalidomide-O-PEG4-Propargyl Spectrum

Thalidomide-O-PEG4-Propargyl(2098799-77-8)1HNMR

2098799-77-8 (Thalidomide-O-PEG4-Propargyl) Related Search:

1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- Cereblon Ligand 1 E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-linker 10
Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-PEG4-Boc
tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-linker 13 E3 Ligase Ligand-Linker Conjugates 20

1of3

Thalidomide-O-PEG4-Propargyl 4-((3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione Thalidomide-PEG4-Propargyl E3 Ligase Ligand-Linker Conjugates,Thalidomide-PEG-4-Propargyl,inhibit,Inhibitor,Thalidomide PEG4 Propargyl,ThalidomidePEG4Propargyl 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)- Thalidomide-4-PEG4-O-Propargyl 2-(2,6-Dioxo-3-piperidinyl)-4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)-1H-isoindole-1,3(2H)-dione 2098799-77-8 peg PROTACs-Please select