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Thalidomide-O-PEG4-Propargyl

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Thalidomide-O-PEG4-Propargyl Basic information
Product Name:Thalidomide-O-PEG4-Propargyl
Synonyms:Thalidomide-O-PEG4-Propargyl;4-((3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;Thalidomide-PEG4-Propargyl;E3 Ligase Ligand-Linker Conjugates,Thalidomide-PEG-4-Propargyl,inhibit,Inhibitor,Thalidomide PEG4 Propargyl,ThalidomidePEG4Propargyl;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)-;Thalidomide-4-PEG4-O-Propargyl;2-(2,6-Dioxo-3-piperidinyl)-4-(3,6,9,12-tetraoxapentadec-14-yn-1-yloxy)-1H-isoindole-1,3(2H)-dione
CAS:2098799-77-8
MF:C24H28N2O9
MW:488.49
EINECS:
Product Categories:peg;PROTACs-Please select
Mol File:2098799-77-8.mol
Thalidomide-O-PEG4-Propargyl Structure
Thalidomide-O-PEG4-Propargyl Chemical Properties
Boiling point 673.9±55.0 °C(Predicted)
density 1.320±0.06 g/cm3(Predicted)
storage temp. -20°C, stored under nitrogen
solubility Soluble in Water, DMF, DCM, DMSO
pka10.70±0.40(Predicted)
form Solid
color White to light yellow
Safety Information
HS Code 2933998090
MSDS Information
Thalidomide-O-PEG4-Propargyl Usage And Synthesis
DescriptionThalidomide-O-PEG4-Propargyl is synthesized compound that incorporates the Thalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology, Propargyl is reactive with azide molecule in the presence of Cu catalyst.
UsesThalidomide-PEG4-Propargyl is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. Thalidomide-PEG4-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50Cereblon
References[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-998. DOI:10.1016/j.str.2020.07.015
Thalidomide-O-PEG4-Propargyl Preparation Products And Raw materials
Tag:Thalidomide-O-PEG4-Propargyl(2098799-77-8) Related Product Information
1H-Isoindole-1,3(2H)-dione, 4-[2-(2-aminoethoxy)ethoxy]-2-(2,6-dioxo-3-piperidinyl)- Cereblon Ligand 1 E3 Ligase Ligand-Linker Conjugates 21 E3 Ligase Ligand-Linker Conjugates 19 Thalidomide-linker 10 Acetamide, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-N-3,6,9,12-tetraoxapentadec-14-yn-1-yl- Thalidomide-O-amido-C4-NH2 hydrochloride Thalidomide-O-amido-PEG3-C2-NH2 hydrochloride Thalidomide-O-amido-C8-NH2 hydrochloride Thalidomide-O-PEG4-Boc tert-butyl 3,3'-(2-aMino-2-((3-tert-butoxy-3-oxopropoxy)Methyl)propane-1,3-diyl)bis(oxy)dipropanoate Thalidomide-linker 13 E3 Ligase Ligand-Linker Conjugates 20