5-Fluoro-2-iodobenzoic acid
- CAS No.
- 52548-63-7
- Chemical Name:
- 5-Fluoro-2-iodobenzoic acid
- Synonyms
- 5-Fluoro-2-iodobenzoic acid;5-Flluoro-2-iodobenzoic acid;Benzoic acid, 5-fluoro-2-iodo-
- CBNumber:
- CB7947162
- Molecular Formula:
- C7H4FIO2
- Molecular Weight:
- 266.01
- MDL Number:
- MFCD00837316
- MOL File:
- 52548-63-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 145-149 °C |
|---|---|
| Boiling point | 307.9±27.0 °C(Predicted) |
| Density | 2.074±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 2.52±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| Sensitive | Light Sensitive |
| InChI | InChI=1S/C7H4FIO2/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3H,(H,10,11) |
| InChIKey | XPFMQYOPTHMSJJ-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(F)=CC=C1I |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-45 | |||||||||
| RIDADR | UN 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2916310090 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
5-Fluoro-2-iodobenzoic acid price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 678902 | 5-Fluoro-2-iodobenzoic acid 97% | 52548-63-7 | 1g | $150 | 2026-04-30 | Buy |
| TCI Chemical | F1113 | 5-Fluoro-2-iodobenzoic Acid >98.0%(GC)(T) | 52548-63-7 | 1g | $64 | 2026-04-30 | Buy |
| TCI Chemical | F1113 | 5-Fluoro-2-iodobenzoic Acid >98.0%(GC)(T) | 52548-63-7 | 5g | $250 | 2026-04-30 | Buy |
| Apolloscientific | PC2699 | 5-Fluoro-2-iodobenzoic acid 98% | 52548-63-7 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC2699 | 5-Fluoro-2-iodobenzoic acid 98% | 52548-63-7 | 5g | $36 | 2026-06-04 | Buy |
5-Fluoro-2-iodobenzoic acid Chemical Properties, Uses, Production
Uses
5-Fluoro-2-iodobenzoic acid is an important intermediate for the production of pharmaceuticals and agrochemicals.
Synthesis
446-08-2
52548-63-7
Step 1: 2-Amino-5-fluorobenzoic acid (25 g, 0.162 mol) was dissolved in 2N HCl solution (350 mL) and cooled to 0-5°C. At this temperature, a solution of sodium nitrite (11.2 g, 0.16 mol) in water (150 mL) was slowly added dropwise. After the dropwise addition was completed, the reaction mixture was continued to be stirred at 0-5°C for 90 min. Subsequently, the resulting diazonium salt solution was added dropwise to a solution of potassium iodide (53 g, 0.32 mol) and cuprous(I) iodide (15.2 g, 0.081 mol) in water (150 mL) that had been pre-cooled to about 5 °C. After completion of the dropwise addition, the reaction mixture was transferred to room temperature and stirred for 18 hours. The completion of the reaction was monitored by TLC (unfolding agent: EtOAc). At the end of the reaction, the mixture was filtered and the solid product was collected. The solid residue was diluted with methyl tert-butyl ether (MTBE, 500 mL), refluxed for 20 min and filtered. The filtrate was concentrated to give 5-fluoro-2-iodobenzoic acid (30 g, 75% yield) as a yellow solid. The product was characterized by 1H NMR (400 MHz, methanol-d4): δ 8.04-8.00 (m, 1H), 7.59-7.56 (m, 1H), 7.08-7.03 (m, 1H).
References
[1] Patent: WO2013/132376, 2013, A1. Location in patent: Page/Page column 151
[2] Chemistry--A European Journal, 2014, vol. 20, # 36, p. 11336 - 11339,4
[3] Patent: US2006/52378, 2006, A1. Location in patent: Page/Page column 146
[4] Patent: US2003/187014, 2003, A1
[5] Patent: WO2010/31, 2010, A1. Location in patent: Page/Page column 70
5-Fluoro-2-iodobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| WUXI SHUANGQI TECHNOLOGY CO LTD. | 0510-86529556 18114865355 | 1702606491@qq.com | China | 1104 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 5-Fluoro-2-iodobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 5-Fluoro-2-iodobenzoic acid
52548-63-7
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-03-20 | 5-Fluoro-2-iodobenzoic acid
52548-63-7
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-04-04 | 5-Fluoro-2-iodobenzoic acid
52548-63-7
|
1KG | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd.
|
-
- 5-Fluoro-2-iodobenzoic acid
52548-63-7
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 5-Fluoro-2-iodobenzoic acid
52548-63-7
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Fluoro-2-iodobenzoic acid
52548-63-7
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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