1-(2-Hydroxyethyl)-4-methylpiperazine
- CAS No.
- 5464-12-0
- Chemical Name:
- 1-(2-Hydroxyethyl)-4-methylpiperazine
- Synonyms
- 2-(4-Methylpiperazin-1-yl)ethan-1-ol;2-(4-METHYLPIPERAZIN-1-YL)ETHANOL;4-Methylpiperazine-1-ethanol;4-Methyl-1-piperazineethanol;1-[N-Methylpiperazine]ethanol;2-(4-methylpiperazinyl)ethanol;1-piperazineethanol, 4-methyl-;4-Methylpiperazine-1-ethanol>2-(4-Methyl-1-piperazinyl)ethanol;1-hydroxyethyl-4-methylpiperazine
- CBNumber:
- CB8187583
- Molecular Formula:
- C7H16N2O
- Molecular Weight:
- 144.21
- MDL Number:
- MFCD03840691
- MOL File:
- 5464-12-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 39-41°C |
|---|---|
| Boiling point | 54-55°C/0.5mbar |
| Density | 1.003±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 14.96±0.10(Predicted) |
| form | Low Melting Solid |
| color | Slightly yellow |
| InChI | InChI=1S/C7H16N2O/c1-8-2-4-9(5-3-8)6-7-10/h10H,2-7H2,1H3 |
| InChIKey | QHTUMQYGZQYEOZ-UHFFFAOYSA-N |
| SMILES | N1(CCO)CCN(C)CC1 |
| CAS DataBase Reference | 5464-12-0(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-36/37/39-24/25-23 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29339900 | |||||||||
| NFPA 704 |
|
1-(2-Hydroxyethyl)-4-methylpiperazine price More Price(69)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M2499 | 4-Methylpiperazine-1-ethanol >98.0%(GC)(T) | 5464-12-0 | 5g | $27 | 2026-04-30 | Buy |
| TCI Chemical | M2499 | 4-Methylpiperazine-1-ethanol >98.0%(GC)(T) | 5464-12-0 | 25g | $106 | 2026-04-30 | Buy |
| Usbiological | 280013 | 1-(2-Hydroxyethyl)-4-methylpiperazine Asreported | 5464-12-0 | 2g | $333 | 2026-06-03 | Buy |
| Usbiological | 280013 | 1-(2-Hydroxyethyl)-4-methylpiperazine Asreported | 5464-12-0 | 5g | $480 | 2026-06-03 | Buy |
| Usbiological | 280013 | 1-(2-Hydroxyethyl)-4-methylpiperazine Asreported | 5464-12-0 | 10g | $648 | 2026-06-03 | Buy |
1-(2-Hydroxyethyl)-4-methylpiperazine Chemical Properties, Uses, Production
Chemical Properties
slightly yellow low melting solid
Synthesis
109-01-3
540-51-2
5464-12-0
The general procedure for the synthesis of 1-(2-hydroxyethyl)-4-methylpiperazine from N-methylpiperazine and 2-bromoethanol was as follows: 2-bromoethanol (2.36 g, 19 mmol) was added slowly and dropwise to a reaction flask containing a mixture of anhydrous ethanol (150 μL) with 1-methylpiperazine (1.26 g, 13 mmol) and potassium carbonate (5.0 g, 36 mmol). The reaction mixture was heated under reflux conditions for 18 hours. Upon completion of the reaction, the mixture was allowed to cool to room temperature and filtered to remove the insoluble precipitate. Subsequently, the solvent was removed by rotary evaporation. The residue was treated with a solvent mixture of acetone/dichloromethane (v/v ratio not specified), filtered again to remove the insoluble material, and finally the solvent was removed by rotary evaporation to afford 1-(2-hydroxyethyl)-4-methylpiperazine (870 mg, 48% yield) as a light brown oil. The product was confirmed by 1H NMR (CDCl3): δ 2.18 (s, 3H); 2.3-2.7 (br m, 8H); 2.56 (t, 2H); 3.61 (t, 2H).MS-ESI showed a molecular ion peak of 145 [MH]+.
References
[1] Patent: WO2004/7498, 2004, A2. Location in patent: Page 29
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 7, p. 622 - 626
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 14, p. 6305 - 6320
[4] Patent: US6291455, 2001, B1
[5] Patent: US2003/225111, 2003, A1. Location in patent: Page 41
1-(2-Hydroxyethyl)-4-methylpiperazine Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Yangzhou Prince Chemical Co., Ltd | 0514-84248359 13328140016;15052570758;15949050037 | sales@princechem.com | China | 99 | 58 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
View Latest Price from 1-(2-Hydroxyethyl)-4-methylpiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-02 | 1-(2-Hydroxyethyl)-4-methylpiperazine
5464-12-0
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2020-01-08 | 1-(2-Hydroxyethyl)-4-methylpiperazine
5464-12-0
|
$1.00 | 1ASSAYS | 99.0% | 100kg | Career Henan Chemical Co |
-
- 1-(2-Hydroxyethyl)-4-methylpiperazine
5464-12-0
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 1-(2-Hydroxyethyl)-4-methylpiperazine
5464-12-0
- $1.00
- 99.0%
- Career Henan Chemical Co
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