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1-(2-Hydroxyethyl)-4-methylpiperazine

1-(2-Hydroxyethyl)-4-methylpiperazine structure

CAS No.: 5464-12-0

Chemical Name:: 1-(2-Hydroxyethyl)-4-methylpiperazine

Synonyms: 4-Methylpiperazine-1-ethanol;4-Methyl-1-piperazineethanol;1-[N-Methylpiperazine]ethanol;2-(4-methylpiperazinyl)ethanol;1-piperazineethanol, 4-methyl-;4-Methylpiperazine-1-ethanol>2-(4-Methyl-1-piperazinyl)ethanol;2-(4-METHYLPIPERAZIN-1-YL)ETHANOL;1-hydroxyethyl-4-methylpiperazine;1-(2-Hydroxyethyl)-4-methyl-piper

CBNumber:: CB8187583

Molecular Formula:: C7H16N2O

Molecular Weight:: 144.21

MDL Number:: MFCD03840691

MOL File:: 5464-12-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:25

Product description	Number	Pack Size	Price
4-Methylpiperazine-1-ethanol >98.0%(GC)(T)	M2499	5g	$27
4-Methylpiperazine-1-ethanol >98.0%(GC)(T)	M2499	25g	$106
1-(2-Hydroxyethyl)-4-methylpiperazine	H949523	500mg	$65
1-(2-Hydroxyethyl)-4-methylpiperazine	H949523	100mg	$45
1-(2-Hydroxyethyl)-4-methylpiperazine 95%	OR0879	25g	$45
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1-(2-Hydroxyethyl)-4-methylpiperazine Properties

Melting point	39-41°C
Boiling point	54-55°C/0.5mbar
Density	1.003±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	soluble in Methanol
form	Low Melting Solid
pka	14.96±0.10(Predicted)
color	Slightly yellow
InChI	InChI=1S/C7H16N2O/c1-8-2-4-9(5-3-8)6-7-10/h10H,2-7H2,1H3
InChIKey	QHTUMQYGZQYEOZ-UHFFFAOYSA-N
SMILES	N1(CCO)CCN(C)CC1
CAS DataBase Reference	5464-12-0(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Risk Statements

36/37/38-20/21/22

Safety Statements

26-36/37/39-24/25-23

Hazard Note

Harmful

HazardClass

IRRITANT

HS Code

29339900

NFPA 704

	1
2		0

1-(2-Hydroxyethyl)-4-methylpiperazine price More Price(37)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	M2499	4-Methylpiperazine-1-ethanol >98.0%(GC)(T)	5464-12-0	5g	$27	2026-03-19	Buy
TCI Chemical	M2499	4-Methylpiperazine-1-ethanol >98.0%(GC)(T)	5464-12-0	25g	$106	2026-03-19	Buy
TRC	H949523	1-(2-Hydroxyethyl)-4-methylpiperazine	5464-12-0	500mg	$65	2021-12-16	Buy
TRC	H949523	1-(2-Hydroxyethyl)-4-methylpiperazine	5464-12-0	100mg	$45	2021-12-16	Buy
Apolloscientific	OR0879	1-(2-Hydroxyethyl)-4-methylpiperazine 95%	5464-12-0	25g	$45	2021-12-16	Buy

Product number	Packaging	Price	Buy
M2499	5g	$27	Buy
M2499	25g	$106	Buy
H949523	500mg	$65	Buy
H949523	100mg	$45	Buy
OR0879	25g	$45	Buy

1-(2-Hydroxyethyl)-4-methylpiperazine Chemical Properties,Uses,Production

Chemical Properties

slightly yellow low melting solid

Synthesis

109-01-3

540-51-2

5464-12-0

The general procedure for the synthesis of 1-(2-hydroxyethyl)-4-methylpiperazine from N-methylpiperazine and 2-bromoethanol was as follows: 2-bromoethanol (2.36 g, 19 mmol) was added slowly and dropwise to a reaction flask containing a mixture of anhydrous ethanol (150 μL) with 1-methylpiperazine (1.26 g, 13 mmol) and potassium carbonate (5.0 g, 36 mmol). The reaction mixture was heated under reflux conditions for 18 hours. Upon completion of the reaction, the mixture was allowed to cool to room temperature and filtered to remove the insoluble precipitate. Subsequently, the solvent was removed by rotary evaporation. The residue was treated with a solvent mixture of acetone/dichloromethane (v/v ratio not specified), filtered again to remove the insoluble material, and finally the solvent was removed by rotary evaporation to afford 1-(2-hydroxyethyl)-4-methylpiperazine (870 mg, 48% yield) as a light brown oil. The product was confirmed by 1H NMR (CDCl3): δ 2.18 (s, 3H); 2.3-2.7 (br m, 8H); 2.56 (t, 2H); 3.61 (t, 2H).MS-ESI showed a molecular ion peak of 145 [MH]+.

References

[1] Patent: WO2004/7498, 2004, A2. Location in patent: Page 29
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 7, p. 622 - 626
[3] Journal of Medicinal Chemistry, 2017, vol. 60, # 14, p. 6305 - 6320
[4] Patent: US6291455, 2001, B1
[5] Patent: US2003/225111, 2003, A1. Location in patent: Page 41

1-(2-Hydroxyethyl)-4-methylpiperazine Preparation Products And Raw materials

Raw materials

Formaldehyde Formic acid 1-(2-Hydroxyethyl)piperazine 1-Methylpiperazine 2-Bromoethanol

2-Chloroethanol Acetone Potassium carbonate Dichloromethane Ethanol

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Preparation Products

1-(2-Hydroxyethyl)-4-methylpiperazine Suppliers

Global( 206)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29795	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3992	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Accela ChemBio Inc.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from 1-(2-Hydroxyethyl)-4-methylpiperazine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	1-(2-Hydroxyethyl)-4-methylpiperazine 5464-12-0	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
	2020-01-08	1-(2-Hydroxyethyl)-4-methylpiperazine 5464-12-0	US $1.00 / ASSAYS	1ASSAYS	99.0%	100kg	Career Henan Chemical Co

1-(2-Hydroxyethyl)-4-methylpiperazine
5464-12-0
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1-(2-Hydroxyethyl)-4-methylpiperazine
5464-12-0
US $1.00 / ASSAYS
99.0%
Career Henan Chemical Co

1-(2-Hydroxyethyl)-4-methylpiperazine Spectrum

1-(2-Hydroxyethyl)-4-methylpiperazine(5464-12-0)¹HNMR

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1-(2-HYDROXYETHYL)-4-METHYLPIPERAZINE 2-(4-METHYLPIPERAZIN-1-YL)ETHANOL 1-(N-HYDROXYETHYL)-4-METHYL PIPERAZINE N-Hydroxyethyl-N’-methylpiperazine 1-(2-Hydroxyethyl)-4-methylpiperazine 95% 2-(4-methylpiperazinyl)ethanol 4-METHYL-1-(2-HYDROXYETHYL)PIPERAZINE 4-Methyl-1-(2-hydroxyethyl)piperizine 4-METHYL-1-(2-HYDROXYETHYL)PIPERAZINE1-(2-HYDROXYETHYL)-4-METHYLPIPERAZINE 1-(2-HYDROXYETHYL)-4-METHYL-PIPERAZINE >98% 2-(4-Methyl-1-piperazinyl)ethanol 4-Methylpiperazine-1-ethanol 1-piperazineethanol, 4-methyl- 1-(2-Hydroxyethyl)-4-methylpiperazine ,97% 2-(4-Methylpiperazin-1-yl)ethan-1-ol 1-(2-Hydroxyethyl)-4-Methylpiperazine, 98% 1GR 2-(4-Methylpiperazin-1-yl)ethan-1-ol, 1-Hydroxy-2-(4-methylpiperazin-1-yl)ethane 1-[N-Methylpiperazine]ethanol N-(2-Hydroxyethyl)-N'-methylpiperazine 4-Methylpiperazine-1-ethanol> 1-hydroxyethyl-4-methylpiperazine 1-(2-Hydroxyethyl)-4-methyl-piper 4-Methyl-1-piperazineethanol 5464-12-0 piperazines Pyrans, Piperidines &Piperazines Pyrans, Piperidines & Piperazines