3-Chloro-2-fluorophenylboronic acid
- CAS No.
- 352535-82-1
- Chemical Name:
- 3-Chloro-2-fluorophenylboronic acid
- Synonyms
- Te4052;3-Chloro-2-fluorophenylboronic aci;3-Chloro-2-fluorophenylboronic acid;2-Fluoro-3-chlorophenylboronic acid;3-CHLORO-2-FLUOROBENZENEBORONIC ACID;Boronic acid, B-(3-chloro-2-fluorophenyl)-;3-CHLORO-2-FLUOROBENZENEBORONIC ACID; 3-CHLORO-2-FLUOROPHENYLBORONIC ACID;3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride);3-Chloro-2-fluorobenzeneboronic Acid (contains varying amounts of Anhydride)
- CBNumber:
- CB8189017
- Molecular Formula:
- C6H5BClFO2
- Molecular Weight:
- 174.37
- MDL Number:
- MFCD05664224
- MOL File:
- 352535-82-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 223 °C (dec.)(lit.) |
|---|---|
| Boiling point | 315.1±52.0 °C(Predicted) |
| Density | 1.41±0.1 g/cm3(Predicted) |
| storage temp. | Inert atmosphere,2-8°C |
| form | powder to crystal |
| pka | 7.35±0.58(Predicted) |
| color | White to Almost white |
| Water Solubility | Insoluble in water. Soluble in organic solvents. |
| CAS DataBase Reference | 352535-82-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HS Code | 2931900090 | |||||||||
| NFPA 704 |
|
3-Chloro-2-fluorophenylboronic acid price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C2946 | 3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride) | 352535-82-1 | 1g | $41 | 2026-04-30 | Buy |
| TCI Chemical | C2946 | 3-Chloro-2-fluorophenylboronic Acid (contains varying amounts of Anhydride) | 352535-82-1 | 5g | $135 | 2026-04-30 | Buy |
| Activate Scientific | AS48670 | (3-Chloro-2-fluorophenyl)boronic acid 97% | 352535-82-1 | 1g | $20 | 2026-06-04 | Buy |
| Activate Scientific | AS48670 | (3-Chloro-2-fluorophenyl)boronic acid 97% | 352535-82-1 | 5g | $42 | 2026-06-04 | Buy |
| Activate Scientific | AS48670 | (3-Chloro-2-fluorophenyl)boronic acid 97% | 352535-82-1 | 25g | $103 | 2026-06-04 | Buy |
3-Chloro-2-fluorophenylboronic acid Chemical Properties,Uses,Production
Uses
3-Chloro-2-fluorobenzeneboronic acid, Is used inorganic synthesis, catalysis, analytical chemistry and biological systems.
Synthesis
144584-65-6
352535-82-1
The general procedure for the synthesis of 3-chloro-2-fluorophenylboronic acid from 3-chloro-2-fluorobromobenzene was as follows: 16 g (72 mmol) of 1-bromo-3-chloro-2-fluorobenzene was added to a 500 mL three-necked flask and the air in the flask was displaced with nitrogen. Subsequently, 200 mL of tetrahydrofuran was added and the solution was cooled to -80 °C under a stream of nitrogen. 48 mL (76 mmol) of n-butyllithium (1.6 mol/L hexane solution) was slowly added dropwise with a syringe to this cooled solution, and after the dropwise addition was completed, the reaction mixture was continued to be stirred at the same temperature for 1.5 hours. After that, 9.0 mL (80 mmol) of trimethyl borate was added to the reaction mixture and gradually warmed up to room temperature (20 °C), where stirring was continued for about 19 hours. Upon completion of the reaction, about 100 mL of 1 mol/L hydrochloric acid was added to the resulting solution and the mixture was stirred. The organic layer was separated, washed with water, and the aqueous layer was extracted twice with toluene. The organic layer and the toluene extract were combined and washed with saturated aqueous sodium chloride solution. The combined organic layers were dried with anhydrous magnesium sulfate followed by gravity filtration. The filtrate was concentrated to give 4.5 g of the light yellow solid product 3-chloro-2-fluorophenylboronic acid in 35% yield.
References
[1] Patent: WO2014/69613, 2014, A1. Location in patent: Paragraph 0274; 0275; 0276
[2] Patent: WO2015/29796, 2015, A1
3-Chloro-2-fluorophenylboronic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9513 | 58 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
View Lastest Price from 3-Chloro-2-fluorophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | (3-Chloro-2-fluorophenyl)boronic acid
352535-82-1
|
$2.20-8.80 | 1kg | 99%min | 1000kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2019-12-23 | 3-CHLORO-2-FLUOROPHENYLBORONIC ACID
352535-82-1
|
$1.00 | 1g | 99.99% | 200kg | Career Henan Chemical Co |
-
- (3-Chloro-2-fluorophenyl)boronic acid
352535-82-1
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 3-CHLORO-2-FLUOROPHENYLBORONIC ACID
352535-82-1
- $1.00
- 99.99%
- Career Henan Chemical Co
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