5-Nitrobenzothiophene
- CAS No.
- 4965-26-8
- Chemical Name:
- 5-Nitrobenzothiophene
- Synonyms
- 5-nitrobenzo[b]thiophene;5-NITROBENZOTHIOPHENE;5-nitro-1-benzothiophene;Benzo[b]thiophene, 5-nitro-;5-Nitrobenzothiophene ISO 9001：2015 REACH
- CBNumber:
- CB8208222
- Molecular Formula:
- C8H5NO2S
- Molecular Weight:
- 179.2
- MDL Number:
- MFCD01159605
- MOL File:
- 4965-26-8.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934999090 |
5-Nitrobenzothiophene price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR938440 | 5-Nitrobenzothiophene >98% | 4965-26-8 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR938440 | 5-Nitrobenzothiophene >98% | 4965-26-8 | 250mg | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR938440 | 5-Nitrobenzothiophene >98% | 4965-26-8 | 1g | $29 | 2026-06-04 | Buy |
| Apolloscientific | OR938440 | 5-Nitrobenzothiophene >98% | 4965-26-8 | 5g | $89 | 2026-06-04 | Buy |
| Apolloscientific | OR938440 | 5-Nitrobenzothiophene >98% | 4965-26-8 | 25g | $437 | 2026-06-04 | Buy |
5-Nitrobenzothiophene Chemical Properties, Uses, Production
Synthesis
6345-55-7
4965-26-8
5-Nitro-1-benzothiophene-2-carboxylic acid (40 g, 179 mmol) was dissolved in quinoline (350 mL) under mechanical stirring followed by addition of copper powder (11.3 g, 179 mmol). The reaction mixture was heated to 190°C until complete gas release. After completion of the reaction, the mixture was cooled to room temperature and poured into crushed ice and acidified with concentrated hydrochloric acid. The resulting suspension was extracted with ethyl acetate and the organic layer was separated and washed sequentially with 2N hydrochloric acid, water and saturated brine. The organic layer was dried over anhydrous sodium sulfate and concentrated to give 5-nitrobenzothiophene (30.5 g, 95% yield). The structure of the product was confirmed by 1H NMR (DMSO-d6, 400 MHz) and LC-MS (electrospray): 1H NMR δ 8.85 (d, 1H), 8.31 (d, 1H), 8.18 (dd, 1H), 8.06 (d, 1H), 7.73 (d, 1H); LC-MS m/z = 180 [M + H]+.
References
[1] Bioorganic and Medicinal Chemistry, 2016, vol. 24, # 3, p. 403 - 427
[2] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 8, p. 735 - 740
[3] ACS Medicinal Chemistry Letters, 2017, vol. 8, # 3, p. 338 - 343
[4] Patent: WO2006/66172, 2006, A1. Location in patent: Page/Page column 27
[5] Synthetic Communications, 1991, vol. 21, # 7, p. 959 - 964
5-Nitrobenzothiophene Preparation Products And Raw materials
Raw materials
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Preparation Products
5-Nitrobenzothiophene Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Wuhan Haizheng Industry & Trade Development Co. Ltd | 027-8866 0053/88660577/88660578 | China | 1070 | 55 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 1999 | 58 |
| Zhengzhou Alfachem Co., Ltd. | 0371-53765687 18937137882 | 3969243885@qq.com | China | 7734 | 55 |
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443;18052965989 | tongbenwan22@163.com | China | 1975 | 55 |
| Henan CoreyChem Co., Ltd | 0371-86658258 | info@coreychem.com | China | 10442 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
View Latest Price from 5-Nitrobenzothiophene manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-Nitrobenzothiophene
4965-26-8
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2019-12-25 | 5-Nitrobenzothiophene
4965-26-8
|
$1.00 | 1g | ≥98% | Career Henan Chemical Co |
-
- 5-Nitrobenzothiophene
4965-26-8
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Nitrobenzothiophene
4965-26-8
- $1.00
- ≥98%
- Career Henan Chemical Co
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