ISOSTEVIOL
- CAS No.
- 27975-19-5
- Chemical Name:
- ISOSTEVIOL
- Synonyms
- ISOSTEVIOL;Nsc 231875;Ccris 6121;Isosteviol-RM;Isosteviol, BR;(-)-Isosteviol;ISOSTEVIOL STANDARD;ISOSTEVIOL USP/EP/BP;Iso-Stevio 27975-19-5;Isosteviol (NSC 231875)
- CBNumber:
- CB8324052
- Molecular Formula:
- C20H30O3
- Molecular Weight:
- 318.45
- MDL Number:
- MFCD28411514
- MOL File:
- 27975-19-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 228.0 to 232.0 °C |
|---|---|
| Boiling point | 455.6±38.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO:81.5(Max Conc. mg/mL);255.92(Max Conc. mM) |
| form | Solid |
| pka | 4.69±0.60(Predicted) |
| color | White to Almost white |
| InChI | InChI=1/C20H30O3/c1-17-9-5-14-18(2)7-4-8-19(3,16(22)23)13(18)6-10-20(14,12-17)11-15(17)21/h13-14H,4-12H2,1-3H3,(H,22,23)/t13-,14,17-,18+,19+,20-/s3 |
| InChIKey | KFVUFODCZDRVSS-MVXPDRGUNA-N |
| SMILES | C12CC[C@@]3(C(=O)C[C@@]1(CC[C@]1([H])[C@](C)(C(=O)O)CCC[C@@]21C)C3)C |&1:3,7,10,12,20,r| |
| EWG's Food Scores | 1 |
| FDA UNII | 091QB7QO95 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS02 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301+H311+H331-H314-H341-H225 |
| Precautionary statements | P501-P261-P270-P202-P240-P210-P233-P201-P243-P241-P242-P271-P264-P280-P370+P378-P308+P313-P361+P364-P303+P361+P353-P301+P330+P331-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P403+P233-P403+P235-P405 |
| WGK Germany | 3 |
| HS Code | 2918.30.9000 |
| Storage Class | 11 - Combustible Solids |
ISOSTEVIOL price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL82395 | Isosteviol phyproof? Reference Substance | 27975-19-5 | 20mg | $273 | 2026-04-30 | Buy |
| Sigma-Aldrich | 92273 | Isosteviol analytical standard | 27975-19-5 | 10mg | $235 | 2022-05-15 | Buy |
| TCI Chemical | I1069 | Isosteviol >98.0%(GC)(T) | 27975-19-5 | 100mg | $61 | 2026-04-30 | Buy |
| TCI Chemical | I1069 | Isosteviol >98.0%(GC)(T) | 27975-19-5 | 500mg | $297 | 2026-04-30 | Buy |
| Cayman Chemical | 36916 | Isosteviol ≥98% | 27975-19-5 | 100mg | $87 | 2026-04-30 | Buy |
ISOSTEVIOL Chemical Properties,Uses,Production
Chemical Properties
White crystals, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Stevia rebaudiana Bertoni, also known as stevia and sweet grass.
Uses
Isosteviol is a tetracyclic diterpenoid with a beyerane core has drawn attention because it can exhibit antihypertensive activity, reduce blood glucose, suppress cancer cells.
Definition
ChEBI: Isosteviol is a diterpenoid.
Synthesis
57817-89-7
27975-19-5
A new structure based on (2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl((4R,4aS,6aR,9S,11aR,11bS)-9-(((2S,3R,4S,5S,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-(((2S,3R,4S,5S,6R )-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)oxy-4,11b-dimethyl-8-methylenetetradecahydro-6a,9-methylcyclohepta[a]naphthalene-4-carboxylic acid ester was synthesized by 10% sulfuric acid hydrolysis reaction. The reaction conditions were conventional hydrolysis conditions without additional catalyst or special temperature control. The product was purified in 93% yield with the melting point of 228.4-230.8 °C. The structure of the product was confirmed by IR, 1H NMR, 13C NMR and HRMS.The IR spectrum showed that the characteristic absorption peaks were located at 3448, 2955, 2924, 2848, 1736, 1692, 1453, 1404, 1373, 1320, 1268, 1214, 1180, 1150, 1108, 973, 950, 796, 589 cm-1 . 796, 589 cm-1.1H NMR (400 MHz, CDCl3) δ: 2.64 (dd, J = 18.64, 3.76 Hz, 1H), 2.17 (d, J = 13.40 Hz, 1H), 1.90-1.37 (m, 13H), 1.25 (s, 3H), 1.22-1.14 (m, 3H), 1.06- 1.03 (m, 1H), 0.98 (s, 3H), 0.95-0.88 (m, 1H), 0.78 (s, 3H).13C NMR (100 MHz, CDCl3) δ: 224.22, 184.33, 56.79, 57.62, 56.09, 54.83, 49.73, 49.59, 44.38. 42.02, 40.42, 38.99, 38.34, 32.80, 29.69, 22.32, 20.57, 19.55, 14.04. HRMS (ESI) m/z: [M + Na]+ Calculated value C20H30O3Na 341.2093, measured value 341.2085.
References
[1] Chemistry and Biodiversity, 2013, vol. 10, # 2, p. 177 - 188
[2] Bioorganic and Medicinal Chemistry Letters, 1997, vol. 7, # 19, p. 2485 - 2490
[3] European Journal of Medicinal Chemistry, 2016, vol. 115, p. 26 - 40
[4] Journal of Chemical Crystallography, 2009, vol. 39, # 2, p. 108 - 111
[5] Journal of Chemical Crystallography, 2011, vol. 41, # 4, p. 519 - 522
ISOSTEVIOL Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Yuxin Technology Co., Ltd. | 13558691827 | yuxinpharma@126.com | China | 95 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9831 | 58 |
| Nanjing Spring & Autumn Biological Engineering Co., Ltd. | 17388075642 13815430202 | sale02@cqherb.com | China | 261 | 59 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
View Lastest Price from ISOSTEVIOL manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | Isosteviol
27975-19-5
|
$41.00-98.00 | 99.90% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | ISOSTEVIOL
27975-19-5
|
1KG | 99% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2026-05-28 | ISOSTEVIOL
27975-19-5
|
$9.00 | 1KG | 99.9 | 1 ton | Hebei Chuanghai Biotechnology Co,.LTD |
-
- Isosteviol
27975-19-5
- $41.00-98.00
- 99.90%
- TargetMol Chemicals Inc.
-
- ISOSTEVIOL
27975-19-5
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- ISOSTEVIOL
27975-19-5
- $9.00
- 99.9
- Hebei Chuanghai Biotechnology Co,.LTD
