7-(4-tert-Butylbenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
- CAS No.
- 333415-38-6
- Chemical Name:
- 7-(4-tert-Butylbenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione
- Synonyms
- VU0071063;TOSLAB 808036;VU0071063, 10 mM in DMSO;7-(4-(tert-butyl)benzyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione;7-(4-tert-Butylbenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;7-[[4-(1,1-Dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione;1H-Purine-2,6-dione, 7-[[4-(1,1-dimethylethyl)phenyl]methyl]-3,7-dihydro-1,3-dimethyl-;Hyperpolarization,KcsA,Potassium Channel,Alzheimer,inhibit,B-cell,Specific,Potent,VU0071063,Insulin,Inhibitor
- CBNumber:
- CB8325206
- Molecular Formula:
- C18H22N4O2
- Molecular Weight:
- 326.39
- MDL Number:
- MFCD02648040
- MOL File:
- Mol file
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: soluble10mg/mL, clear |
| form | powder |
| color | white to beige |
| InChI | 1S/C18H22N4O2/c1-18(2,3)13-8-6-12(7-9-13)10-22-11-19-15-14(22)16(23)21(5)17(24)20(15)4/h6-9,11H,10H2,1-5H3 |
| InChIKey | ZFZAIHKQJBMYLO-UHFFFAOYSA-N |
| SMILES | CN(C1=C2N(CC3=CC=C(C(C)(C)C)C=C3)C=N1)C(N(C)C2=O)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
7-(4-tert-Butylbenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1142 | VU0071063 ≥98% (HPLC) | 333415-38-6 | 25mg | $446 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1142 | VU0071063 ≥98% (HPLC) | 333415-38-6 | 5mg | $103 | 2025-07-31 | Buy |
| Cayman Chemical | 21897 | VU0071063 ≥98% | 333415-38-6 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 21897 | VU0071063 ≥98% | 333415-38-6 | 5mg | $110 | 2026-04-30 | Buy |
| Cayman Chemical | 21897 | VU0071063 ≥98% | 333415-38-6 | 10mg | $203 | 2026-04-30 | Buy |
7-(4-tert-Butylbenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione Chemical Properties, Uses, Production
Description
VU0071063 is a potent and selective activator of the inward-rectifier potassium channel (Kir) 6.2 and sulfonylurea receptor (SUR) 1 (EC50 = 7 μM using whole cell patch clamp electrophysiology). It is selective for SUR1-containing Kir6.1 or Kir6.2 channels over SUR2A, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3/2, and voltage-gated potassium channel 2.1. VU0071063 inhibits glucose-stimulated calcium entry in isolated mouse pancreatic β-cells.
Uses
VU0071063 is a potent and specific Kir6.2/SUR1 opener (EC50=7.44 μM) and can be used for investigating Kir6.2/SUR1 expressed in the pancreas and brain. VU0071063 inhibits insulin secretion by inducing hyperpolarization of β-cell membrane potential. VU0071063 chemotype has a very steep structure-activity relationships[1][2].
in vivo
VU0071063 (50 mg/kg; i.p.; 4 hours) leads to a significant increase in blood glucose at 60 minutes[1].
| Animal Model: | Male C57BL/6 mice (10-12 weeks age)[1] |
| Dosage: | 50 mg/kg (Pharmacokinetic analysis) |
| Administration: | I.p. |
| Result: | Led to a significant increase in blood glucose at 60 minutes. |
storage
Store at -20°C
References
[1] Kharade SV, et al. Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063. J Pharmacol Exp Ther. 2019;370(3):350-359. DOI:10.1124/jpet.119.257204
[2] Raphemot R, et al. Direct activation of β-cell KATP channels with a novel xanthine derivative. Mol Pharmacol. 2014;85(6):858-865. DOI:10.1124/mol.114.091884
7-(4-tert-Butylbenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione Preparation Products And Raw materials
Raw materials
Preparation Products
7-(4-tert-Butylbenzyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2308 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9780 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4578 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4372 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Labnetwork lnc. | +86-27-50766799 +86-18062016861 | contact@labnetwork.com | China | 19981 | 58 |
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