NS 1619
- CAS No.
- 153587-01-0
- Chemical Name:
- NS 1619
- Synonyms
- NS 161;NS 1619;NS1619;NS 1619;NS-1619, 10 mM in DMSO;NS 1619, KCa1.1 channel activator;NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN;1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b;1-(2-Hydroxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2-Ol;1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one;1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE
- CBNumber:
- CB8359809
- Molecular Formula:
- C15H8F6N2O2
- Molecular Weight:
- 362.23
- MDL Number:
- MFCD00928190
- MOL File:
- 153587-01-0.mol
| Product description | Number | Pack Size | Price |
| NS 1619 powder | N170 | 5mg | $183.91 |
| NS 1619 powder | N170 | 25mg | $663 |
| NS-1619 min. 95.0 % | N1191 | 10MG | $157 |
| NS-1619 min. 95.0 % | N1191 | 50MG | $469 |
| NS 1619 ≥98% | 18876 | 1mg | $37 |
| More product size | |||
| Density | 1.563±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL |
| pka | 8.32±0.48(Predicted) |
| form | solid |
| color | white |
| Water Solubility |
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47mg/mL ethanol: 26.6mg/mL 0.1 M NaOH: 5.2mg/mL DMSO: 5.3mg/mL H2O: insoluble |
| InChI | InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25) |
| InChIKey | YLFMCMWKHSDUCT-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C2=CC(C(F)(F)F)=CC=C2O)C2=CC=C(C(F)(F)F)C=C2N1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
NS 1619 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N170 | NS 1619 powder | 153587-01-0 | 5mg | $183.91 | 2025-07-31 | Buy |
| Sigma-Aldrich | N170 | NS 1619 powder | 153587-01-0 | 25mg | $663 | 2025-07-31 | Buy |
| TCI Chemical | N1191 | NS-1619 min. 95.0 % | 153587-01-0 | 10MG | $157 | 2025-07-31 | Buy |
| TCI Chemical | N1191 | NS-1619 min. 95.0 % | 153587-01-0 | 50MG | $469 | 2025-07-31 | Buy |
| Cayman Chemical | 18876 | NS 1619 ≥98% | 153587-01-0 | 1mg | $37 | 2024-03-01 | Buy |
NS 1619 Chemical Properties,Uses,Production
Uses
NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart.
Definition
ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Biochem/physiol Actions
NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.
in vivo
Opening of KCa channels with NS-1619 (1 mg/kg; i.p.) can delay protection in mouse hearts[3].
| Animal Model: | Adult male outbred ICR mice[3] |
| Dosage: | 1 mg/kg |
| Administration: | Pretreated i.p. 24 h before I/R |
| Result: | Pretreatment induced delayed protection 24 h later. Resulted in significant cardioprotection 24 h later, i.e., infarct size was reduced from 38.8 ± 3.7% to 19.8 ± 2.9%. |
storage
+4°C
NS 1619 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29795 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32469 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Henan Alfa Chemical Co., Ltd | +8615838112936 | sale03@alfachem.cn | China | 9164 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| RR Scientific LLC | +86-13917743231 | sales@rrscientific.com | United States | 878 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 24597 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39043 | 58 |
