NS 1619
- CAS No.
- 153587-01-0
- Chemical Name:
- NS 1619
- Synonyms
- 1-(2-hydroxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazol-2(3H)-one;NS 161;NS 1619;NS1619;NS 1619;NS-1619, 10 mM in DMSO;NS 1619, KCa1.1 channel activator;NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN;1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b;1-(2-Hydroxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2-Ol;1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE
- CBNumber:
- CB8359809
- Molecular Formula:
- C15H8F6N2O2
- Molecular Weight:
- 362.23
- MDL Number:
- MFCD00928190
- MOL File:
- 153587-01-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Density | 1.563±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL |
| pka | 8.32±0.48(Predicted) |
| form | solid |
| color | white |
| Water Solubility |
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47mg/mL ethanol: 26.6mg/mL 0.1 M NaOH: 5.2mg/mL DMSO: 5.3mg/mL H2O: insoluble |
| InChI | InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25) |
| InChIKey | YLFMCMWKHSDUCT-UHFFFAOYSA-N |
| SMILES | C1(=O)N(C2=CC(C(F)(F)F)=CC=C2O)C2=CC=C(C(F)(F)F)C=C2N1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.32 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
NS 1619 price More Price(44)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N170 | NS 1619 powder | 153587-01-0 | 5mg | $208 | 2026-04-30 | Buy |
| Sigma-Aldrich | N170 | NS 1619 powder | 153587-01-0 | 25mg | $711 | 2026-04-30 | Buy |
| TCI Chemical | N1191 | NS-1619 min. 95.0 % | 153587-01-0 | 10MG | $126 | 2026-04-30 | Buy |
| TCI Chemical | N1191 | NS-1619 min. 95.0 % | 153587-01-0 | 50MG | $375 | 2026-04-30 | Buy |
| Cayman Chemical | 18876 | NS 1619 ≥98% | 153587-01-0 | 1mg | $41 | 2026-04-30 | Buy |
NS 1619 Chemical Properties,Uses,Production
Uses
NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart.
Definition
ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i an opener/activator of the large-conductance calcium-activated potassium channel (Bkca).
Biochem/physiol Actions
NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury.
in vivo
Opening of KCa channels with NS-1619 (1 mg/kg; i.p.) can delay protection in mouse hearts[3].
| Animal Model: | Adult male outbred ICR mice[3] |
| Dosage: | 1 mg/kg |
| Administration: | Pretreated i.p. 24 h before I/R |
| Result: | Pretreatment induced delayed protection 24 h later. Resulted in significant cardioprotection 24 h later, i.e., infarct size was reduced from 38.8 ± 3.7% to 19.8 ± 2.9%. |
storage
+4°C
NS 1619 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
