LOUREIRIN B
- CAS No.
- 119425-90-0
- Chemical Name:
- LOUREIRIN B
- Synonyms
- ColouringB;LOUREIRIN B;Loureirin B-RM;cochinchinenin B;LOUREIRIN B USP/EP/BP;Loureirin B (Standard);Loureirin B, 10 mM in DMSO;1-Propanone,1-(4-hydroxyphenyl)-3-(2,4,6-triMethoxyphenyl);1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one;Loureirin B, 98%, from Dracaena cochinchinensis (Lour.) S. C. Chen
- CBNumber:
- CB8388351
- Molecular Formula:
- C18H20O5
- Molecular Weight:
- 316.35
- MDL Number:
- MFCD07781421
- MOL File:
- 119425-90-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 509.9±50.0 °C(Predicted) |
|---|---|
| Density | 1.177±0.06 g/cm3(Predicted) |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml |
| pka | 8.06±0.15(Predicted) |
| form | powder |
| color | White |
| InChI | 1S/C18H20O5/c1-21-14-10-17(22-2)15(18(11-14)23-3)8-9-16(20)12-4-6-13(19)7-5-12/h4-7,10-11,19H,8-9H2,1-3H3 |
| InChIKey | ZPFRAPVRYLGYEC-UHFFFAOYSA-N |
| SMILES | O(C)c1c(c(cc(c1)OC)OC)CCC(=O)c2ccc(cc2)O |
| FDA UNII | P47L69798O |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29145090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
LOUREIRIN B price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL84235 | Loureirin B phyproof® Reference Substance | 119425-90-0 | 10 mg | $437 | 2026-04-30 | Buy |
| Cayman Chemical | 27454 | Loureirin B ≥98% | 119425-90-0 | 1mg | $53 | 2026-04-30 | Buy |
| Cayman Chemical | 27454 | Loureirin B ≥98% | 119425-90-0 | 5mg | $245 | 2026-04-30 | Buy |
| Cayman Chemical | 27454 | Loureirin B ≥98% | 119425-90-0 | 10mg | $433 | 2026-04-30 | Buy |
| Cayman Chemical | 27454 | Loureirin B ≥98% | 119425-90-0 | 25mg | $888 | 2026-04-30 | Buy |
LOUREIRIN B Chemical Properties, Uses, Production
Chemical Properties
White powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the resin of the Dracaena frondosa tree.
Uses
Loureirin B is a component of traditional Chinese medicine which helps combat neurodegenerative diseases. Extracted from the red resin of Dracaena cochinchinensis S.C Chen, known as Dragon’s Blood.
Synthesis
After benzyl protection, 4-hydroxyacetophenone undergoes condensation with 2,4,6-trimethoxybenzaldehyde under strong base catalysis (such as sodium hydroxide) to generate the corresponding chalcone intermediate. Finally, hydrogenation is carried out at atmospheric pressure using palladium on carbon (Pd/C) as a catalyst to remove the benzyl protecting group and simultaneously reduce the chalcone double bond, yielding Loureirin B.
in vivo
Loureirin B significantly improves the arrangement and deposition of collagen fibres, decreases protein levels of ColI, ColIII and α-SMA and suppresses myofibroblast differentiation and scar proliferative activity, in a rabbit ear scar model. Loureirin B effectively inhibits TGF-β1-induced upregulation of ColI, ColIII and α-SMA levels, myofibroblast differentiation and the activation of Smad2 and Smad3, in NS fibroblasts[3].
IC 50
PAI-1: 26.1 μM (IC50); KATP; ERK; JNK
LOUREIRIN B Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| ShangHai YuanYe Biotechnology Co., Ltd. | 15026964105 | shyysw007@163.com | China | 4998 | 60 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| Chengdu Climax Biotech Co., Ltd. | 028-83311324 1278112614 | climaxbiotech@gmail.com | China | 925 | 58 |
| Shanghai Winherb Medical Technology Co., Ltd. | 17301719108 13341702378 | winherb@126.com | China | 1245 | 58 |
View Latest Price from LOUREIRIN B manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Loureirin B
119425-90-0
|
$48.00-179.00 | 99.83% | 10g | TargetMol Chemicals Inc. | ||
 |
2023-02-24 | Loureirin B
119425-90-0
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | ||
 |
2020-01-10 | 1-Propanone,1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)-
119425-90-0
|
$9.80 | 1KG | ≥98% | 20 tons | Career Henan Chemical Co |
-
- Loureirin B
119425-90-0
- $48.00-179.00
- 99.83%
- TargetMol Chemicals Inc.
-
- Loureirin B
119425-90-0
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- 1-Propanone,1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)-
119425-90-0
- $9.80
- ≥98%
- Career Henan Chemical Co
