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LOUREIRIN B

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LOUREIRIN B manufacturers

  • Loureirin B
  • Loureirin B pictures
  • $48.00
  • 2026-07-27
  • CAS:119425-90-0
  • Purity: 99.83%
  • Supply Ability: 10g
  • Loureirin B
  • Loureirin B pictures
  • 2023-02-24
  • CAS:119425-90-0
  • Min. Order: 5mg
  • Purity: ≥98%(HPLC)
  • Supply Ability: 10 g
LOUREIRIN B Basic information
Product Name:LOUREIRIN B
Synonyms:LOUREIRIN B;1-Propanone,1-(4-hydroxyphenyl)-3-(2,4,6-triMethoxyphenyl);Loureirin B, 98%, from Dracaena cochinchinensis (Lour.) S. C. Chen;1-(4-hydroxyphenyl)-3-(2,4,6-trimethoxyphenyl)propan-1-one;cochinchinenin B;LOUREIRIN B USP/EP/BP;ColouringB;Loureirin B-RM
CAS:119425-90-0
MF:C18H20O5
MW:316.35
EINECS:
Product Categories:chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
Mol File:119425-90-0.mol
LOUREIRIN B Structure
LOUREIRIN B Chemical Properties
Boiling point 509.9±50.0 °C(Predicted)
density 1.177±0.06 g/cm3(Predicted)
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
pka8.06±0.15(Predicted)
form powder
color White
InChI1S/C18H20O5/c1-21-14-10-17(22-2)15(18(11-14)23-3)8-9-16(20)12-4-6-13(19)7-5-12/h4-7,10-11,19H,8-9H2,1-3H3
InChIKeyZPFRAPVRYLGYEC-UHFFFAOYSA-N
SMILESO(C)c1c(c(cc(c1)OC)OC)CCC(=O)c2ccc(cc2)O
Safety Information
Safety Statements 24/25
WGK Germany WGK 3
HS Code 29145090
Storage Class11 - Combustible Solids
MSDS Information
LOUREIRIN B Usage And Synthesis
Chemical PropertiesWhite powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from the resin of the Dracaena frondosa tree.
UsesLoureirin B is a component of traditional Chinese medicine which helps combat neurodegenerative diseases. Extracted from the red resin of Dracaena cochinchinensis S.C Chen, known as Dragon’s Blood.
SynthesisAfter benzyl protection, 4-hydroxyacetophenone undergoes condensation with 2,4,6-trimethoxybenzaldehyde under strong base catalysis (such as sodium hydroxide) to generate the corresponding chalcone intermediate. Finally, hydrogenation is carried out at atmospheric pressure using palladium on carbon (Pd/C) as a catalyst to remove the benzyl protecting group and simultaneously reduce the chalcone double bond, yielding Loureirin B.
in vivo

Loureirin B significantly improves the arrangement and deposition of collagen fibres, decreases protein levels of ColI, ColIII and α-SMA and suppresses myofibroblast differentiation and scar proliferative activity, in a rabbit ear scar model. Loureirin B effectively inhibits TGF-β1-induced upregulation of ColI, ColIII and α-SMA levels, myofibroblast differentiation and the activation of Smad2 and Smad3, in NS fibroblasts[3].

IC 50PAI-1: 26.1 μM (IC50); KATP; ERK; JNK
LOUREIRIN B Preparation Products And Raw materials
Tag:LOUREIRIN B(119425-90-0) Related Product Information
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