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5-CHLORO-2-NITROANISOLE

5-CHLORO-2-NITROANISOLE structure

CAS No.: 6627-53-8

Chemical Name:: 5-CHLORO-2-NITROANISOLE

Synonyms: 5-CHLORO-2-NITROANISOLE;2-nitro-5-chloroanisole;5-Chloro-2-nitroanisole,97%;5-CHLORO-2-NITROANISOLE 97%;4-CHLORO-2-METHOXYNITROBENZENE;4-CHLORO-3-METHOXY NITRO BENZNE;4-chloro-2-methoxy-1-nitro-benzen;4-Chloro-3-methoxy-1-nitrobenzene;4-chloro-2-methoxy-1-nitro-benzene;4-Chloro-2-methoxynitrobenzene 98%

CBNumber:: CB9281491

Molecular Formula:: C7H6ClNO3

Molecular Weight:: 187.58

MDL Number:: MFCD00007288

MOL File:: 6627-53-8.mol

MSDS File:: SDS

Last updated:2026-05-28 06:22:44

Product description	Number	Pack Size	Price
5-Chloro-2-nitroanisole 97%	C58606	10g	$90.1
5-Chloro-2-nitroanisole 97%	C58606	25g	$154
5-Chloro-2-nitroanisole Asreported	269392	5g	$362
5-Chloro-2-nitroanisole Asreported	269392	10g	$501
5-Chloro-2-nitroanisole Asreported	269392	25g	$679
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5-CHLORO-2-NITROANISOLE Properties

Melting point	70-72 °C(lit.)
Boiling point	289.1±20.0 °C(Predicted)
Density	1.4219 (rough estimate)
refractive index	1.6000 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Ethyl Acetate
form	Solid
color	Yellow
InChI	InChI=1S/C7H6ClNO3/c1-12-7-4-5(8)2-3-6(7)9(10)11/h2-4H,1H3
InChIKey	ABEUJUYEUCCZQF-UHFFFAOYSA-N
SMILES	C1([N+]([O-])=O)=CC=C(Cl)C=C1OC
CAS DataBase Reference	6627-53-8(CAS DataBase Reference)
FDA UNII	SVY2LTV7GJ
EPA Substance Registry System	5-Chloro-2-nitroanisole (6627-53-8)
UNSPSC Code	12352100

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H350i

Precautionary statements

P202-P264-P270-P280-P301+P312-P308+P313

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-37/39-36

WGK Germany

TSCA

TSCA listed

HS Code

2909309090

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 4 Oral
Carc. 1B Inhalation

NFPA 704

	0
1		0

5-CHLORO-2-NITROANISOLE price More Price(59)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C58606	5-Chloro-2-nitroanisole 97%	6627-53-8	10g	$90.1	2023-06-20	Buy
Sigma-Aldrich	C58606	5-Chloro-2-nitroanisole 97%	6627-53-8	25g	$154	2023-01-07	Buy
Usbiological	269392	5-Chloro-2-nitroanisole Asreported	6627-53-8	5g	$362	2026-06-03	Buy
Usbiological	269392	5-Chloro-2-nitroanisole Asreported	6627-53-8	10g	$501	2026-06-03	Buy
Usbiological	269392	5-Chloro-2-nitroanisole Asreported	6627-53-8	25g	$679	2026-06-03	Buy

Product number	Packaging	Price	Buy
C58606	10g	$90.1	Buy
C58606	25g	$154	Buy
269392	5g	$362	Buy
269392	10g	$501	Buy
269392	25g	$679	Buy

5-CHLORO-2-NITROANISOLE Chemical Properties,Uses,Production

Chemical Properties

SLIGHTLY YELLOW TO GREEN CRYSTALLINE POWDER

Uses

5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs (1). In addition, it is used in the synthesis of kinesin spindle protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells (2).

Synthesis

611-07-4

74-88-4

6627-53-8

To 5-chloro-2-nitrophenol (40 g, 0.23 mol) and iodomethane (49 g, 0.345 mol) in DMF (200 mL), K2CO3 (47.6 g, 0.345 mol) was added. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was partitioned between ethyl acetate and water. The organic layer was separated, washed with brine, dried over MgSO4, filtered and concentrated in vacuum. The residue was purified by silica gel column chromatography (with petroleum ether as eluent) to afford the target product 2-nitro-5-chloroanisole (30 g, 70% yield).

References

[1] Liebigs Annalen der Chemie, 1988, p. 203 - 208
[2] Patent: US2014/288045, 2014, A1. Location in patent: Paragraph 0461
[3] Patent: WO2016/44772, 2016, A1. Location in patent: Paragraph 323

5-CHLORO-2-NITROANISOLE Preparation Products And Raw materials

Raw materials

2-Methoxy-4-nitroaniline 2-CHLORO-5-NITROANISOLE Sodium bisulfite Copper(II) sulfate 5-Chloro-2-nitrophenol

Iodomethane Potassium carbonate N,N-Dimethylformamide

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Preparation Products

4-CHLORO-2-ANISIDINE HYDROCHLORIDE

5-CHLORO-2-NITROANISOLE Suppliers

Global( 188)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	20111	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29626	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32997	60
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Nanjing Dolon Biotechnology Co.,Ltd.	18905173768	52513593@qq.com	CHINA	2971	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63645	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10817	58
CONIER CHEM AND PHARMA LIMITED		sales@conier.com	China	49906	58
Fuxin Pharmaceutical	+86-021-021-50872116	contact@fuxinpharm.com	China	9976	58
Zhengzhou Alfa Chemical Co.,Ltd	+86-18530059196	sale04@alfachem.cn	China	9636	58

Supplier	Advantage
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
Changzhou Ansciep Chemical Co., Ltd.	58
Nanjing Dolon Biotechnology Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Fuxin Pharmaceutical	58
Zhengzhou Alfa Chemical Co.,Ltd	58

View Lastest Price from 5-CHLORO-2-NITROANISOLE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-17	5-CHLORO-2-NITROANISOLE 6627-53-8	$1.00-100.00	1KG	99%		Henan Fengda Chemical Co., Ltd
	2020-02-26	5-Chloro-2-nitroanisole 6627-53-8		1KG	99.0%	100 tons	Shaanxi Dideu Medichem Co. Ltd

5-CHLORO-2-NITROANISOLE
6627-53-8
$1.00-100.00
99%
Henan Fengda Chemical Co., Ltd

5-Chloro-2-nitroanisole
6627-53-8
99.0%
Shaanxi Dideu Medichem Co. Ltd

5-CHLORO-2-NITROANISOLE Spectrum

5-CHLORO-2-NITROANISOLE(6627-53-8)MS 5-CHLORO-2-NITROANISOLE(6627-53-8)¹HNMR 5-CHLORO-2-NITROANISOLE(6627-53-8)¹³CNMR 5-CHLORO-2-NITROANISOLE(6627-53-8)IR1 5-CHLORO-2-NITROANISOLE(6627-53-8)IR2 5-CHLORO-2-NITROANISOLE(6627-53-8)Raman

6627-53-8(5-CHLORO-2-NITROANISOLE)Related Search:

1-CHLORO-2,5-DIETHOXY-4-NITROBENZENE 1-Chloro-2,5-dimethoxy-4-nitrobenzene 5-CHLORO-2-NITROANISOLE 1-Bromo-2-chloro-4-methoxy-5-nitrobenzene 4-CHLORO-3-NITROANISOLE,4-Chloro-3-Nitroanisole98%(Gc),4-CHLORO-3-NITROANISOLE,98%

4-CHLORO-2-ETHOXY-1-NITROBENZENE 1,4-DIBUTOXY-2-CHLORO-5-NITROBENZENE 4-CHLORO-2-NITROANISOLE,4-CHLORO-2-NITROANISOLE, 98+%,4-Chloro-2-nitroanisole, 99+%,p-Chloro-o-nitroanisole 2-CHLORO-4-NITROANISOLE 98+%,2-CHLORO-4-NITROANISOLE 2-CHLORO-5-NITROANISOLE

2-Nitroanisole 1-CHLORO-5-METHOXY-4-NITRO-2-(TRIFLUOROMETHYL)BENZENE 2-Chloro-3-nitroanisole 2-Amino-4-chloro-5-nitroanisole 3-Chloro-5-nitroanisole

4-Chloro-2-NitroAnisole(89-21-4) 1-CHLORO-5-(3,5-DIMETHYLPHENOXY)-4-NITRO-2-(TRIFLUOROMETHYL)BENZENE 5-CHLORO-3-METHOXY-2-NITROBENZOIC ACID

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4-chloro-2-methoxy-1-nitro-benzen 5-CHLORO-2-NITROANISOLE 4-CHLORO-2-METHOXYNITROBENZENE 4-Chloro-2-methoxynitrobenzene 98% 4-chloro-2-methoxy-1-nitro-benzene 4-Chloro-3-methoxy-1-nitrobenzene 5-CHLORO-2-NITROANISOLE 97% 5-Chloro-2-nitroanisole,97% 4-Chloro-2-methoxynitrobenzene, 5-Chloro-2-nitrophenyl methyl ether Benzene, 4-chloro-2-methoxy-1-nitro- 5-CHLORO-2-NITROANISOLE ISO 9001：2015 REACH 4-Chloro-2-Methoxy Nitrobenzene, or 5-Chloro-2-Nitro Anisole 4-CHLORO-3-METHOXY NITRO BENZNE 2-nitro-5-chloroanisole 2-Nitro-5-chlorophenylmethyl ether 6627-53-8 ClC6H3NO2OCH3 Nitro Compounds Organic Building Blocks Nitrogen Compounds Building Blocks Building Blocks Chemical Synthesis Nitro Compounds Nitrogen Compounds Organic Building Blocks Anisole Nitro Compounds Nitrogen Compounds Organic Building Blocks blocks NitroCompounds Miscellaneous