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3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide structure

CAS No.: 185259-85-2

Chemical Name:: 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide

Synonyms: GR 46611;GR 46611, 5-HT1B/1D agonist;3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide;3-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-2-propenamide;3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]prop-2-enamide;2-Propenamide, 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-

CBNumber:: CB8690764

Molecular Formula:: C23H27N3O2

Molecular Weight:: 377.48

MDL Number:: MFCD00953517

MOL File:: 185259-85-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:55:51

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3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Properties

Boiling point	645.9±55.0 °C(Predicted)
Density	1.168
storage temp.	2-8°C
solubility	DMSO: 28 mg/mL, soluble
pka	14.51±0.46(Predicted)
form	solid
color	white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H315-H335
Precautionary statements	P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3

3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide price More Price(33)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	42235	GR46611 ≥98%	185259-85-2	1mg	$28	2026-04-30	Buy
Cayman Chemical	42235	GR46611 ≥98%	185259-85-2	5mg	$104	2026-04-30	Buy
Cayman Chemical	42235	GR46611 ≥98%	185259-85-2	10mg	$152	2026-04-30	Buy
Cayman Chemical	42235	GR46611 ≥98%	185259-85-2	25mg	$345	2026-04-30	Buy
Biosynth	KHA25985	GR 46611	185259-85-2	50mg	$953	2026-06-04	Buy

Product number	Packaging	Price	Buy
42235	1mg	$28	Buy
42235	5mg	$104	Buy
42235	10mg	$152	Buy
42235	25mg	$345	Buy
KHA25985	50mg	$953	Buy

3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Chemical Properties, Uses, Production

Uses

GR 46611is a 5-HT1D agonist.

Definition

ChEBI: 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-2-propenamide is a member of tryptamines.

Biological Activity

5-HT 1D receptor agonist. Blockade of GR 46611-induced hypothermia in the guinea pig provides a useful model with which to study the potency and duration of action of centrally acting 5-HT 1D receptor ligands.

in vivo

GR-46611 (1 mg/kg, i.p. ) significantly improves survival of Dravet syndrome (DS) mice^[1].
GR-46611 (0.03-300 μg/kg, i.v.) increases threshold volume, bladder capacity, and residual volume in chronic spinal cord injury (SCI) cats^[3].
GR46611 (3-30 mg/kg, s.c.) causes a dose-related decrease in rectal temperature in the adult guinea-pig^[4].

Animal Model:	Dravet syndrome (DS) mice^[1]
Dosage:	0.01, 0.1 and 1 mg/kg
Administration:	Intraperitoneal injection (i.p.)
Result:	Improved survival relative to vehicle treated controls with 89% surviving rate.

IC 50

5-HT_1D Receptor

3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Preparation Products And Raw materials

Raw materials

Preparation Products

3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Suppliers

Global Suppliers ( 53)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Hangzhou Sage Chemical Co., Ltd.	+86057186818502 13588463833	info@sagechem.com	China	10265	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4859	55
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8435	60
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8000	62
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9729	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
Jinan ponder chemical co. LTD	0531-0000	thinklifescience@163.com	China	19684	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
BOC Sciences	65
Hangzhou Sage Chemical Co., Ltd.	58
Shanghai Lollane Biological Technology Co.,Ltd.	55
EMMX Biotechnology LLC	60
Shanghai YuanYe Biotechnology Co., Ltd.	60
ShangHai Biochempartner Co.,Ltd	62
Shanghai Chaolan Chemical Technology Center	58
TargetMol Chemicals Inc.	58
Jinan ponder chemical co. LTD	58

View Latest Price from 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-10	GR 46611 185259-85-2	$84.00-278.00		99.90%	10g	TargetMol Chemicals Inc.

GR 46611
185259-85-2
$84.00-278.00
99.90%
TargetMol Chemicals Inc.

3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide Spectrum

3-[3-(2-DIMETHYLAMINOETHYL)-1H-INDOL-5-YL]-N-(4-METHOXYBENZYL)ACRYLAMIDE(185259-85-2)¹HNMR

185259-85-2 (3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide) Related Search:

3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide 5-Methyl-N,N-dimethyltryptamine FTBMT BU 224 hydrochloride Piribedil N-Oxide

ACP-105

1of2

GR 46611 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]prop-2-enamide 2-Propenamide, 3-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]- GR 46611, 5-HT1B/1D agonist 3-[3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl]-N-[(4-methoxyphenyl)methyl]-2-propenamide 3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide 185259-85-2