3-Chloro-2-methoxyphenylboronic acid
- CAS No.
- 179898-50-1
- Chemical Name:
- 3-Chloro-2-methoxyphenylboronic acid
- Synonyms
- 3-Chloro-2-methoxyphenylboronic acid;3-Chloro-2-methoxybenzeneboronicacid;3-Chloro-2-methoxybenzeneboronic acid 99%;Boronic acid, B-(3-chloro-2-methoxyphenyl)-;Boronic acid, (3-chloro-2-methoxyphenyl)- (9CI);3-Chloro-2-methoxyphenylboronic acid (contains varying amounts of Anhydride)
- CBNumber:
- CB8698407
- Molecular Formula:
- C7H8BClO3
- Molecular Weight:
- 186.4
- MDL Number:
- MFCD08277278
- MOL File:
- 179898-50-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| HS Code | 2931900090 |
3-Chloro-2-methoxyphenylboronic acid price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | C4157 | (3-Chloro-2-methoxyphenyl)boronic Acid (contains varying amounts of Anhydride) | 179898-50-1 | 1G | $63 | 2026-04-30 | Buy |
| Activate Scientific | AS47588 | (3-Chloro-2-methoxyphenyl)boronic acid 97% | 179898-50-1 | 1g | $47 | 2026-06-04 | Buy |
| Activate Scientific | AS47588 | (3-Chloro-2-methoxyphenyl)boronic acid 97% | 179898-50-1 | 5g | $114 | 2026-06-04 | Buy |
| Apolloscientific | OR400468 | 3-Chloro-2-methoxybenzeneboronic acid 97% | 179898-50-1 | 250mg | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS47588 | (3-Chloro-2-methoxyphenyl)boronic acid 97% | 179898-50-1 | 25g | $332 | 2026-06-04 | Buy |
3-Chloro-2-methoxyphenylboronic acid Chemical Properties, Uses, Production
Uses
3-Chloro-2-methoxyphenylboronic Acid is a reagent used in the synthesis of a selective 17β-HSD1 inhibitor in the therapeutic treatment of endometriosis.
Synthesis
174913-10-1
5419-55-6
179898-50-1
General procedure for the synthesis of 3-chloro-2-methoxyphenylboronic acid from 1-bromo-3-chloro-2-methoxybenzene and triisopropyl borate: 1-bromo-3-chloro-2-methoxybenzene (113.2 g, 426.4 mmol) was dissolved in tetrahydrofuran (1000 mL), and cooled to -78°C. At the same temperature 1.7 M tertiary-butyllithium (t-BuLi) was added slowly to a tert-butyl lithium (t-BuLi) ) to a hexane solution (251.7 mL, 426.4 mmol). The reaction mixture was stirred at -78°C for 1 h. Triisopropyl borate (B(OiPr)3) (113.2 mL, 852.4 mmol) was added, followed by gradual warming of the reaction mixture to room temperature and continued stirring for 3 hours. Upon completion of the reaction, 2 N aqueous hydrochloric acid (800 mL) was added to the mixture and stirred at room temperature for 1.5 hours. The resulting precipitate was collected by filtration, washed sequentially with water and ether and dried under vacuum. The crude product was recrystallized by a solvent mixture of chloroform and ethyl acetate and dried to give 3-chloro-2-methoxyphenylboronic acid as a white solid (89.6 g, 91% yield; Mass Spectrometry (MS): [M + H]+ = 230.
References
[1] Patent: KR2018/10165, 2018, A. Location in patent: Paragraph 0207-0210
3-Chloro-2-methoxyphenylboronic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9510 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | +86-21-60341587 | sales@topbiochem.com | China | 6166 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
| AllyChem Co., Ltd. | 0411-62313318 13889470786 | info@allychem.com | China | 1021 | 65 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from 3-Chloro-2-methoxyphenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 3-CHLORO-2-METHOXYPHENYLBORONIC ACID
179898-50-1
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
-
- 3-CHLORO-2-METHOXYPHENYLBORONIC ACID
179898-50-1
- $1.00
- 99%
- Career Henan Chemical Co
