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L-Glutamic acid 5-tert-butyl ester

L-Glutamic acid 5-tert-butyl ester Structure
L-Glutamic acid 5-tert-butyl ester structure
CAS No.
2419-56-9
Chemical Name:
L-Glutamic acid 5-tert-butyl ester
Synonyms
H-GLU(OTBU)-OH;Glu(OtBu);(S)-2-aMino-5-(tert-butoxy)-5-oxopentanoic acid;Glu(OtBu)-OH;H-L-Glu(OtBu)-OH;L-Glutamic acid γ-t.-butyl ester;Ethyl[1,1'H-Glu(Orb)-OH;H-GLU(OBUT)-OH;H-GLU(OTBU)-OH H2O
CBNumber:
CB8744074
Molecular Formula:
C9H17NO4
Molecular Weight:
203.24
MDL Number:
MFCD00038580
MOL File:
2419-56-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-08-20 20:20:01
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L-Glutamic acid 5-tert-butyl ester Properties

Melting point 182°C(lit.)
Boiling point 110 °C(Press: 0.05 Torr)
Density 0.992 g/cm3
storage temp. 2-8°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Solid
pka 2.20±0.10(Predicted)
color White to Almost white
Water Solubility Sparingly soluble in water; practically insoluble in ethanol or ether.
BRN 2049031
Major Application peptide synthesis
InChI InChI=1S/C9H17NO4/c1-9(2,3)14-7(11)5-4-6(10)8(12)13/h6H,4-5,10H2,1-3H3,(H,12,13)/t6-/m0/s1
InChIKey OIOAKXPMBIZAHL-LURJTMIESA-N
SMILES C(O)(=O)[C@H](CCC(OC(C)(C)C)=O)N
CAS DataBase Reference 2419-56-9(CAS DataBase Reference)
UNSPSC Code 12352209
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280-P271
PPE Eyeshields, Gloves, type N95 (US)
Risk Statements  22-24
Safety Statements  22-24/25-25
WGK Germany  3
HazardClass  IRRITANT
HS Code  29224999
Storage Class 11 - Combustible Solids
NFPA 704
0
0 0

L-Glutamic acid 5-tert-butyl ester price More Price(76)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 49518 L-Glutamic acid 5-tert-butyl ester ≥98.0% (TLC) 2419-56-9 1g $73.3 2026-04-30 Buy
TCI Chemical B4045 5-tert-Butyl L-Glutamate Hydrate >98.0%(T) 2419-56-9 1g $32 2026-04-30 Buy
TCI Chemical B4045 5-tert-Butyl L-Glutamate Hydrate >98.0%(T) 2419-56-9 5g $107 2026-04-30 Buy
Usbiological 453283 L-Glutamic Acid 5-tert-Butyl Ester 2419-56-9 1g $403 2026-06-03 Buy
Usbiological 453283 L-Glutamic Acid 5-tert-Butyl Ester 2419-56-9 10g $588 2026-06-03 Buy
Product number Packaging Price Buy
49518 1g $73.3 Buy
B4045 1g $32 Buy
B4045 5g $107 Buy
453283 1g $403 Buy
453283 10g $588 Buy

L-Glutamic acid 5-tert-butyl ester Chemical Properties,Uses,Production

Chemical Properties

White powder crystal

Uses

L-Glutamic acid 5-tert-butyl ester is used as a fine chemical intermediate, pharmaceutical intermediate.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

In a 3000mL three-necked flask, 2324g of tert-butyl acetate and 73.5g of glutamic acid were added, stirred, and was added dropwise. 160.8 mL of perchloric acid, react for 48 hours at 10C, cool down to 0C, add 1000 mL of water, extract (the remaining tert-butyl acetate was used as solvent extraction), neutralized with Na2CO3 to pH=8 to 9, partitioned, and then extracted with 400 mL of 1% Na2CO3 aqueous solution was washed three times, and the tert-butyl acetate layer was concentrated under reduced pressure to give 42 g of Glu(OtBu)2 as an oil in 32.4% yield.

In a 1000 mL three-necked flask, 42 g of Glu(OtBu)2 was added, 400 mL of water and 11 g of CuCl2 were added, . The temperature was raised to 50 C and the reaction was carried out for 12 h to produce Cu[Glu(OtBu)]x (x=1-2); then it was lowered to room temperature and was added 19g tetramethylethylenediamine and 100mL dioxane, and then adjust the pH to 8~9 with triethylamine to produce L-glutamic acid-5-tert-butyl ester.

L-Glutamic acid 5-tert-butyl ester synthesis

71989-18-9
2419-56-9
Synthesis of L-Glutamic acid 5-tert-butyl ester from Fmoc-L-glutamic acid 5-tert-butyl ester

L-Glutamic acid 5-tert-butyl ester Preparation Products And Raw materials

Raw materials

L-GlutaMic acid, 5-(1,1-diMethylethyl) 1-(phenylMethyl) ester Z-L-glutamic acid γ-tert·butyl α-benzyl ester Cbz-L-Glutamic acid 1-benzyl ester Z-Glu(OtBu)-OMe L-Glutamic acid alpha-benzyl ester
N-Cbz-L-Glutamic acid 5-tert-butyl ester

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Preparation Products

Fmoc-L-glutamic acid 5-tert-butyl ester L-Glutamic acid, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-, 25-(1,1-dimethylethyl) ester

L-Glutamic acid 5-tert-butyl ester Suppliers

Global( 345)Suppliers
Supplier Tel Email Country ProdList Advantage
Sichuan jiayinglai technology CO.,LTD 028-64159575 1678230860@qq.com China 7315 58
Sichuan jiayinglai technology CO.,LTD 9018 15982359653 1394531348@qq.com China 2271 55
Sichuan Ampebiochem Co., Ltd. 028-65294243 18682730901 sales@ampebiochem.com China 1000 58
Hubei Keji Biomedical Technology Co., Ltd. 15927397714 13971512665 hbkjsw@foxmail.com China 999 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Sichuan Tongsheng Amino acids Co.,Ltd. 0838-2274206 17340404235 sales@biots.cn China 300 66
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Sichuan jiayinglai technology CO.,LTD 58
Sichuan jiayinglai technology CO.,LTD 55
Sichuan Ampebiochem Co., Ltd. 58
Hubei Keji Biomedical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
Sichuan Tongsheng Amino acids Co.,Ltd. 66
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

View Lastest Price from L-Glutamic acid 5-tert-butyl ester manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
L-Glutamic acid 5-tert-butyl ester pictures 2026-09-14 L-Glutamic acid 5-tert-butyl ester
2419-56-9
 $800.00-999.00 1kg 99% 5000 HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
H-L-Glu(OtBu)-OH pictures 2026-09-14 H-L-Glu(OtBu)-OH
2419-56-9
 1kg 98% 1T+ Sichuan HongRi Pharma-Tech Co.,Ltd
L-Glutamic acid 5-tert-butyl ester pictures 2026-08-19 L-Glutamic acid 5-tert-butyl ester
2419-56-9
 1KG 98% 1000 KG Shaanxi Dideu New Materials Co. Ltd

L-Glutamic acid 5-tert-butyl ester Spectrum

L-Glutamic acid 5-tert-butyl ester(2419-56-9)1HNMR

2419-56-9(L-Glutamic acid 5-tert-butyl ester)Related Search:

tert-Butyl methyl ether 4-tert-Butylphenol tert-Butylbenzene Tris(trimethylsilyl)phosphate Methyl acrylate
L-Glutamic acid Butyl acetate Buprofezin Cyhalofop-butyl Methyl 4-tert-butylbenzoate
4-tert-Butylcyclohexyl acetate 4-tert-Butylcatechol L-GLUTAMIC ACID DI-TERT-BUTYL ESTER HCL tert-Butyldimethylsilyl chloride tert-Butyl hydroperoxide
Butyl oleate Glutamic acid L-Glutamic acid dimethyl ester hydrochloride

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L-Glutamic acid γ-t.-butyl ester L-Glutamic acid γ-tert·butyl ester monohydrate L-Glutamic acid 5-t-Butyl Ester GLUTAMIC ACID GAMMA-T-BUTYL ESTER MONOHYDRATE L-GLUTAMIC ACID-Y-T-BUTYL ESTER L-GLUTAMIC ACID-Y-T-BUTYLESTER MONOHYDRATE L-GLUTAMIC ACID .GAMMA.-TERT-BUTYL ESTER MONOHYDRATE L-Glutamic acid (t-butyl) H-GLU(OTBU)-OH H2O H-GLU(OBUT)-OH GLUTAMIC ACID GAMMA-TERT-BUTYL ESTER MONOHYDRATE GLUTAMIC ACID(OTBU)-OH L-Glutamic acid 5-tert-butyl ester, ≥98.0% L-GlutaMic acid, 5-(1,1-diMethylethyl) ester L-Glutamic acid 5-tert-butyl ester >=98.0% (TLC) (2S)-2-amino-5-tert-butoxy-5-keto-valeric acid (2S)-2-ammonio-5-tert-butoxy-5-keto-valerate (2S)-2-ammonio-5-tert-butoxy-5-oxopentanoate (2S)-2-azaniumyl-5-[(2-methylpr (2S)-2-azaniumyl-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoate (2S)-2-azaniumyl-5-tert-butoxy-5-oxo-pentanoate L-Glutamic acid 5-te (2S)-2-Amino-5-tert-butoxy-5-oxopentanoic acid H-Glu(OtBu)-OH·H2O L-GlutaMic acid γ-tert·butyl ester Monohydrate 5-tert-Butyl L-GlutaMate 5-tert-Butyl L-GlutaMate Hydrate (2s)-2-aMino-5-[(2-Methylpropan-2-yl)oxy]-5-oxopentanoic Acid L-Glutamic acid γ-tert-butyl ester≥ 99% (HPLC) L-GLUTAMIC ACID-GAMMA-T-BUTYL ESTER MONOHYDRATE L-GLUTAMIC ACID GAMMA-T-BUTYL ESTER L-GLUTAMIC ACID 5-TERT-BUTYL ESTER L-GAMMA-T-BUTYL GLUTAMATE H-L-GLU(TBU)-OH H2O 5-tert-Butyl L-Glutamate Hydrate> (2S)-2-amino-5-[(2-methylpropan-2-yl)oxy]-5-oxopentanoicaci H-GLU(OTBU) CAS:2419-56-9 L-Glutamic acid 5-tert-butyl ester USP/EP/BP L-Glu-gamma--tert-butyl ester 5-(1,1-Dimethylethyl) hydrogen L-glutamate 5-(tert-Butyl) hydrogen L-glutamate Deglutathin impurity 2 Ethyl[1,1' -biphenyl]-2-ylcarbamate L-Glutamic acid 5-tert-butyl este L-Glutamic acid 5-tert-butyl ester H-Glu(Ot.Bu)-OH 99.0% L-glutamic acidaminoacid-5-tert-butyl ester (S)-2-aMino-5-(tert-butoxy)-5-oxopentanoic acid Glu(OtBu)-OH Glu(OtBu) H-GLU(OTBU)-OH H-L-Glu(OtBu)-OH L-Glutamic acid γ-tert-butyl ester H-Glu(Orb)-OH 2419-56-9 C9H17NO4xH2O C9H17NO4H2O Specialty Synthesis