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2,2'-Thiodiethanol

2,2'-Thiodiethanol structure

CAS No.: 111-48-8

Chemical Name:: 2,2'-Thiodiethanol

Synonyms: THIODIGLYCOL;2-HYDROXYETHYL SULFIDE;Thiodiethanol;Ethanol, 2,2'-thiobis-;2-(2-hydroxy-ethylsulfanyl)-ethanol;Tedegyl;Glycine A;glyecinea;Glyecine A;THYODIGLYCOL

CBNumber:: CB8762940

Molecular Formula:: C4H10O2S

Molecular Weight:: 122.19

MDL Number:: MFCD00002910

MOL File:: 111-48-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 05:47:52

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2,2'-Thiodiethanol Properties

Melting point	−16 °C(lit.)
Boiling point	164-166 °C20 mm Hg(lit.)
Density	1.221 g/mL at 25 °C(lit.)
vapor pressure	0.26Pa at 20℃
refractive index	n20/D 1.5215(lit.)
Flash point	>230 °F
storage temp.	-20°C
solubility	alcohol: miscible(lit.)
form	liquid
pka	14.14±0.10(Predicted)
Merck	14,9330
BRN	1236325
Henry's Law Constant	5.2×10³ mol/(m³Pa) at 25℃, HSDB (2015)
Stability	Stable. Incompatible with strong oxidizing agents. Reacts with a wide variety of compounds. Flammable.
Cosmetics Ingredients Functions	ANTIOXIDANT
LogP	-0.75 at 25℃
Surface tension	54mN/m at 20°C
CAS DataBase Reference	111-48-8(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	9BW5T43J04
NIST Chemistry Reference	Thiodiglycol(111-48-8)
EPA Substance Registry System	Ethanol, 2,2'-thiobis- (111-48-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H319

Precautionary statements

P264-P280-P305+P351+P338-P337+P313

Hazard Codes

Xi,T,F

Risk Statements

36-36/37/38-39/23/24/25-23/24/25-11

Safety Statements

23-26-36/37/39-45-36-36/37-16-7

RIDADR

UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany

RTECS

KM2975000

3-13-23

TSCA

TSCA listed

HS Code

29309090

Hazardous Substances Data

111-48-8(Hazardous Substances Data)

Toxicity

guinea pig,LD50,oral,3960mg/kg (3960mg/kg),KIDNEY, URETER, AND BLADDER: OTHER CHANGES BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)GASTROINTESTINAL: OTHER CHANGES,Journal of Industrial Hygiene and Toxicology. Vol. 23, Pg. 259, 1941.

REACH Registrations

Active

NFPA 704

	1
2		0

2,2'-Thiodiethanol price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	166782	2,2′-Thiodiethanol ≥99%	111-48-8	100g	$58.6	2026-04-30	Buy
Sigma-Aldrich	166782	2,2′-Thiodiethanol ≥99%	111-48-8	500g	$72.9	2026-04-30	Buy
Sigma-Aldrich	ERT-053	Thiodiglycol solution 1000?μg/mL in methanol, ampule of 1.2?mL, certified reference material, Cerilliant?	111-48-8	1.2mL	$126	2022-05-15	Buy
TRC	TRC-T344575-5G	2,2’-Thiodiethanol	111-48-8	5g	$135	2026-06-03	Buy
TRC	TRC-T344575-50G	2,2’-Thiodiethanol	111-48-8	50g	$394	2026-06-03	Buy

Product number	Packaging	Price	Buy
166782	100g	$58.6	Buy
166782	500g	$72.9	Buy
ERT-053	1.2mL	$126	Buy
TRC-T344575-5G	5g	$135	Buy
TRC-T344575-50G	50g	$394	Buy

2,2'-Thiodiethanol Chemical Properties,Uses,Production

Chemical Properties

colourless liquid with characteristic odour.

Uses

antineoplastic, alkylating agent

Definition

ChEBI: A diol that is pentane-1,5-diol in which the methylene group at position 3 is replaced by a sulfur atom

Hazard

Do not use with hydrochloric acid.

Flammability and Explosibility

Not classified

2,2'-Thiodiethanol Preparation Products And Raw materials

Raw materials

Cosolvent 2-Chloroethanol

Preparation Products

phthalogen auxiliary agent BSM phthalogen auxiliary BSK Phthalocyanine auxiliaries No.1 2-Mercaptoethanol 2-chloroethanesulfonyl chloride

2,2'-Thiodiacetic acid Mustard gas ethenylsulfanylethene 4-Amino-2,3-dichlorphenol Antioxidant 1035

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2,2'-Thiodiethanol Spectrum

2,2'-Thiodiethanol(111-48-8)MS 2,2'-Thiodiethanol(111-48-8)¹HNMR 2,2'-Thiodiethanol(111-48-8)¹³CNMR 2,2'-Thiodiethanol(111-48-8)IR1 2,2'-Thiodiethanol(111-48-8)IR2 2,2'-Thiodiethanol(111-48-8)Raman

111-48-8(2,2'-Thiodiethanol)Related Search:

2,2'-Thiodiethanol 2,2'-Sulfonyldiethanol 5-Thio-D-glucose 2,2'-Thiodiacetic acid Antioxidant 1035

DIETHYL THIOGLYCOLATE 96 Carboxymethylmercaptosuccinic acid Thiodisuccinic acid 2-[(2-Phenoxyethyl)thio]acetic acid 2-Phenylethyl-beta-D-thiogalactoside

1,4,10,13-tetraoxa-7,16-dithiacyclooctadecane thiodiethane-1,2-diyl bis(3-aminobut-2-enoate) Bis(2-hydroxyethyl thioethyl)ether Thiol diethylene glycol diacrylate Bis[2-(succiniMidooxycarbonyloxy)ethyl] Sulfone

Thiodigalactoside 5-Thio-D-glucose 6-phosphate diammonium salt Carboxymethanesulfonyl-acetic acid

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beta-hydroxyethylsulfide Bis(2-hydroxyethyl) sulphide Bis(2-hydroxyethyl) thioether bis(2-hydroxyethyl)sulfide2,2’-thiodiethanol Bis(beta-hydroxyethyl) sulfide bis(beta-hydroxyethyl)sulfide Bis(b-hydroxyethyl) sulfide b-Thiodiglycol Di(2-hydroxyethyl) sulfide Diethanol sulfide Dihydroxyethyl sulfide Ethanol, 2,2'-thiobis- Ethanol, 2,2'-thiodi- THIODIETHYLENE GLYCOL THYODIGLYCOL 2,2-THIODIETHANOL 96+% 2,2'-thiodiethanol thiodiglycol 2,2μ-Thiobis(ethanol), Bis(2-hydroxyethyl) sulfide, Thiodiethylene glycol, Thiodiglycol 2,2μ-Thiobis(ethanol), Thiodiethylene glycol, Thiodiglycol 2,2μ-Thiodiethanol solution thiodiethanol, gilydoteA, lyogen T BETA-THIODIGLYCOL BIS(2-HYDROXYETHYL) SULFIDE 2,2'-THIO-BIS[ETHANOL] 2,2-THIODIETHANOL 2-HYDROXYETHYL SULFIDE 2,2'-THIODIETHANOL, 99+% Bis(hydroxyethyl) sulfide b,b'-Dihydroxyethyl sulfide beta,beta’-dihydroxydiethylsulfide beta,beta’-dihydroxyethylsulfide beta,beta'-Dihydroxydiethyl sulfide beta,beta'-Dihydroxyethyl sulfide beta-Bis(hydroxyethyl) sulfide beta-Hydroxyethyl sulfide Glycine A ethanol,2,2’-thiobis- Glyecine A glyecinea Kromfax solvent kromfaxsolvent Sulfide, bis(2-hydroxyethyl) sulfide,bis(2-hydroxyethyl) Tedegyl Thiodiglykol β,β’-dihydroxydiethylsulfide OMEGA,OMEGA'-DIHYDROXYETHYL SULFIDE 2-Hydroxyethyl sulfide omega,omega'-Dihydroxyethyl sulfide Thiodiglycol, 1000 μg/mL 2-Hydroxyethyl Sulfide Thiodiglycol β-3,5-di-tert-butyl-4-hydroxyphenyl)propionic Methyl ester Thiodiglycol solution 2-(2-hydroxy-ethylsulfanyl)-ethanol 2,2’-thiobis-ethano 2,2’-thiodi-ethano 2,2'-Thiodiglycol 3-Thiapentane-1,5-diol b,b'-Dihydroxydiethyl sulfide