AKOS MSC-0782
- CAS No.
- 64622-16-8
- Chemical Name:
- AKOS MSC-0782
- Synonyms
- 2-BROMO-6-CHLOROBENZALDEHYDE;AKOS MSC-0782;Benzaldehyde, 2-broMo-6-chloro-;2-Bromo-6-chlorobenzaldehyde,98%;2-Bromo-6-chlorobenzaldehyde 99%;AKOS MSC-0782 ISO 9001：2015 REACH;2-Bromo-6-chlorobenzaldehyde≥ 98% (GC)
- CBNumber:
- CB8800730
- Molecular Formula:
- C7H4BrClO
- Molecular Weight:
- 219.46
- MDL Number:
- MFCD00266792
- MOL File:
- 64622-16-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 74-76℃ |
|---|---|
| Boiling point | 258.8±20.0 °C(Predicted) |
| Density | 1.698±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | Solid |
| Appearance | White to light yellow Solid |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C7H4BrClO/c8-6-2-1-3-7(9)5(6)4-10/h1-4H |
| InChIKey | NUGMENVSVAURGO-UHFFFAOYSA-N |
| SMILES | C(=O)C1=C(Cl)C=CC=C1Br |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| HS Code | 2913000090 | |||||||||
| NFPA 704 |
|
AKOS MSC-0782 price More Price(66)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR46035 | 2-Bromo-6-chlorobenzaldehyde 99% | 64622-16-8 | 5g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS35708 | 2-Bromo-6-chlorobenzaldehyde 97% | 64622-16-8 | 5g | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR46035 | 2-Bromo-6-chlorobenzaldehyde 99% | 64622-16-8 | 25g | $74 | 2026-06-04 | Buy |
| Activate Scientific | AS35708 | 2-Bromo-6-chlorobenzaldehyde 97% | 64622-16-8 | 25g | $81 | 2026-06-04 | Buy |
| Apolloscientific | OR46035 | 2-Bromo-6-chlorobenzaldehyde 99% | 64622-16-8 | 100g | $224 | 2026-06-04 | Buy |
AKOS MSC-0782 Chemical Properties, Uses, Production
Chemical Properties
White to off-white crystalline powder
Uses
2-Bromo-6-chlorobenzaldehyde plays an important role as a linker, which provides higher selectivity and reactivity in the Buchwald C-N bond forming reaction in order to prepare Bruton's tyrosine kinase inhibitor.
Synthesis
108-37-2
68-12-2
64622-16-8
The general procedure for the synthesis of 2-chloro-6-bromobenzaldehyde from m-chlorobromobenzene and N,N-dimethylformamide was as follows: 1.6 moles of hexane solution (4.5 mL, 2.8 mmol) of butyllithium was added to a 3-liter triple-necked flask fitted with a stirrer, a dosing funnel, a cryogenic thermometer, and a nitrogen inlet tube under the protection of nitrogen, and the temperature of the reaction system was maintained at 0°C. The reaction was carried out in the following manner. Subsequently, anhydrous tetrahydrofuran solution of diisopropylamine (1.13 mL, 8.1 mmol) was added slowly and dropwise. The resulting mixture was stirred at 0 °C for 10 min and then cooled to -78 °C. At this temperature, an anhydrous tetrahydrofuran solution of m-bromochlorobenzene (1.4 g, 7.3 mmol) was added slowly and dropwise, and the reaction mixture was continued to be stirred at -78 °C for 1 hour. Next, anhydrous N,N-dimethylformamide (636 μL) was added. After the reaction solution was slowly warmed to room temperature, the reaction was quenched by the addition of acetic acid (50 mL) and water (50 mL). The aqueous phase was extracted with ether (2 x 50 mL) and the organic phases were combined. The organic phase was washed with dilute aqueous hydrochloric acid and saturated saline in turn, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by fast column chromatography on silica gel with the eluent of 9:1 hexane/ethyl acetate to afford 2-chloro-6-bromobenzaldehyde as an off-white solid (850 mg, 53% yield). The product was confirmed by NMR hydrogen spectrum (300 MHz, CDCl3): δ 10.4 (s, 1H), 7.6 (m, 1H), 7.45 (m, 1H), 7.3 (m, 1H).
References
[1] Organic Process Research and Development, 2014, vol. 18, # 1, p. 228 - 238
[2] Patent: US2009/118546, 2009, A1. Location in patent: Page/Page column 6
[3] Patent: US2015/210687, 2015, A1. Location in patent: Paragraph 0244
[4] Patent: WO2004/99164, 2004, A1. Location in patent: Page 62-63; 21/22
[5] Journal of Heterocyclic Chemistry, 2018, vol. 55, # 3, p. 670 - 684
AKOS MSC-0782 Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou HQ Material Co., Ltd. | 0371-67759225 13526468238 | sale@hqmat.com | China | 1408 | 58 |
| Zhuhai Aobokai Biomedical Technology Co., Ltd. | 400-0628126 | sales-team@aobchem.com.cn | China | 49995 | 58 |
| Shaanxi pure crystal photoelectric technology co. LTD | +86-13152027579 13152027579 | 2589440029@qq.com | China | 462 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
View Latest Price from AKOS MSC-0782 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | AKOS MSC-0782
64622-16-8
|
$1.00 | 1KG | 95% | 500kg | Career Henan Chemical Co |
-
- AKOS MSC-0782
64622-16-8
- $1.00
- 95%
- Career Henan Chemical Co
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