3-Bromo-5-fluorobenzaldehyde
- CAS No.
- 188813-02-7
- Chemical Name:
- 3-Bromo-5-fluorobenzaldehyde
- Synonyms
- 3-Bromo-5-fluorobenzaldehyde;3-FLUORO-5-BROMOBENZALDEHYDE;Benzaldehyde, 3-bromo-5-fluoro-;3-Bromo-5-fluorobenzaldehyde98%;3-Bromo-5-fluorobenzaldehyde 98%;3-BROMO-5-FLUOROBENZALDEHYDE ISO 9001：2015 REACH
- CBNumber:
- CB2175256
- Molecular Formula:
- C7H4BrFO
- Molecular Weight:
- 203.01
- MDL Number:
- MFCD04116319
- MOL File:
- 188813-02-7.mol
- MSDS File:
- SDS
| Melting point | 41-43℃ |
|---|---|
| Boiling point | 231.0±20.0 °C(Predicted) |
| Density | 1.43 |
| storage temp. | Inert atmosphere,2-8°C |
| form | Solid |
| Appearance | White to yellow <41°C Solid,>43°C Liquid |
| Water Solubility | Slightly soluble in water. |
| Sensitive | Light Sensitive |
| CAS DataBase Reference | 188813-02-7(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2913000090 | |||||||||
| NFPA 704 |
|
3-Bromo-5-fluorobenzaldehyde price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 21548 | 3-BROMO-5-FLUOROBENZALDEHYDE 95% | 188813-02-7 | 1G | $15 | 2026-04-30 | Buy |
| AstaTech | 21548 | 3-BROMO-5-FLUOROBENZALDEHYDE 95% | 188813-02-7 | 5G | $37 | 2026-04-30 | Buy |
| AstaTech | 21548 | 3-BROMO-5-FLUOROBENZALDEHYDE 95% | 188813-02-7 | 25G | $155 | 2026-04-30 | Buy |
| Apolloscientific | PC2392 | 3-Bromo-5-fluorobenzaldehyde 98% | 188813-02-7 | 5g | $49 | 2026-06-04 | Buy |
| Apolloscientific | PC2392 | 3-Bromo-5-fluorobenzaldehyde 98% | 188813-02-7 | 25g | $122 | 2026-06-04 | Buy |
3-Bromo-5-fluorobenzaldehyde Chemical Properties, Uses, Production
Uses
3-Bromo-5-fluorobenzaldehyde is an intermediate in organic syntheses. Reatant in the synthesis of 3,4-diamino-3-cyclobutene-1,2-diones, 9,10-Dihydro-9,10-diboraanthracenes.
Synthesis
1435-51-4
68-12-2
188813-02-7
A 2M isopropylmagnesium chloride solution (10 mL, 20 mmol) was dissolved in 5 mL of tetrahydrofuran under ice bath conditions. To this solution was added a tetrahydrofuran solution of 1,3-dibromo-5-fluorobenzene (4.0 g, 15.70 mmol) and the reaction mixture was stirred for 2 hours. The reaction system was then warmed to 20°C and the reaction was continued for 30 minutes. After completion of the reaction, the system was cooled to 0°C, N,N-dimethylformamide (2.5 mL, 31.50 mmol) was slowly added dropwise and the reaction was stirred at this temperature for 1.5 hours. After that, the reaction mixture was stirred at room temperature for 12 hours. At the end of the reaction, the reaction was quenched by adding saturated ammonium chloride solution (20 mL). The reaction mixture was extracted with ethyl acetate (50 mL x 3), the organic phases were combined, dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. Purification by silica gel column chromatography using eluent B afforded the target product 3-bromo-5-fluorobenzaldehyde (2.57 g, yellow liquid) in 81.0% yield.
References
[1] Patent: US6355648, 2002, B1. Location in patent: Page column 33-34
[2] Patent: CN103030646, 2016, B. Location in patent: Paragraph 0738; 0740-0743
[3] European Journal of Organic Chemistry, 2017, vol. 2017, # 4, p. 818 - 826
[4] Patent: US2007/88053, 2007, A1. Location in patent: Page/Page column 21
[5] Patent: CN105722823, 2016, A. Location in patent: Paragraph 0502; 0503
3-Bromo-5-fluorobenzaldehyde Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Latest Price from 3-Bromo-5-fluorobenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-07-06 | 3-BROMO-5-FLUOROBENZALDEHYDE
188813-02-7
|
$2.00 | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- 3-BROMO-5-FLUOROBENZALDEHYDE
188813-02-7
- $2.00
- 99%
- Career Henan Chemical Co
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