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4-(2-hydroxyethyl)benzoic acid

4-(2-hydroxyethyl)benzoic acid Structure
4-(2-hydroxyethyl)benzoic acid structure
CAS No.
46112-46-3
Chemical Name:
4-(2-hydroxyethyl)benzoic acid
Synonyms
4-(2-Hydroxyethyl);4-(2-Hydroxyethyl)benzoic acid;Benzoic acid, 4-(2-hydroxyethyl)-;4-(2-Hydroxyethyl)benzoic acid 95%
CBNumber:
CB8947134
Molecular Formula:
C9H10O3
Molecular Weight:
166.17
MDL Number:
MFCD02114379
MOL File:
46112-46-3.mol
Last updated:2025-07-24 18:13:48
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4-(2-hydroxyethyl)benzoic acid Properties

Melting point 127-128 °C
Boiling point 345.8±25.0 °C(Predicted)
Density 1.256±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
pka 4.26±0.10(Predicted)
Appearance White to off-white Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P280-P301+P312-P305+P351+P338
HS Code  2916399090

4-(2-hydroxyethyl)benzoic acid price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC H515390 4-(2-Hydroxyethyl)benzoicAcid 46112-46-3 50mg $45 2021-12-16 Buy
SynQuest Laboratories 2629-1-97 4-(2-Hydroxyethyl)benzoic acid 46112-46-3 1g $376 2021-12-16 Buy
SynQuest Laboratories 2629-1-97 4-(2-Hydroxyethyl)benzoic acid 46112-46-3 250mg $189 2021-12-16 Buy
AK Scientific X8079 4-(2-Hydroxyethyl)benzoicacid 46112-46-3 1g $277 2021-12-16 Buy
American Custom Chemicals Corporation CHM0307687 4-(2-HYDROXYETHYL)BENZOIC ACID 95.00% 46112-46-3 5MG $499.57 2021-12-16 Buy
Product number Packaging Price Buy
H515390 50mg $45 Buy
2629-1-97 1g $376 Buy
2629-1-97 250mg $189 Buy
X8079 1g $277 Buy
CHM0307687 5MG $499.57 Buy

4-(2-hydroxyethyl)benzoic acid Chemical Properties,Uses,Production

Synthesis

methyl 4-(2-hydroxyethyl)benzoate

46190-45-8

4-(2-hydroxyethyl)benzoic acid

46112-46-3

General procedure for the synthesis of 4-(2-hydroxyethyl)benzoic acid from methyl 4-(2-hydroxyethyl)benzoate: sodium hydroxide (58 mg, 1.43 mmol) was added to a mixed solution of methanol (3 mL) and water (1 mL) of methyl 4-(2-hydroxyethyl)benzoate (174 mg, 0.96 mmol) at room temperature. The reaction mixture was stirred at room temperature for 48 hours. Upon completion of the reaction, water (5 mL) was added to dilute and extracted with ether (3 x 20 mL) to remove unreacted feedstock and by-products. The aqueous phase was acidified with a 1:1 hydrochloric acid solution to pH=1 and a white solid was precipitated. The solid was collected by filtration to afford 4-(2-hydroxyethyl)benzoic acid (158 mg, 100% yield), and the product could be used in the next reaction without further purification. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.97 (d, J = 8.4 Hz, 2H), 7.27 (d, J = 8.4 Hz, 2H), 3.83 (t, J = 6.3 Hz, 2H), 2.88 (t, J = 6.3 Hz, 2H).

References

[1] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 11, p. 2988 - 2998
[2] Journal of the American Chemical Society, 2006, vol. 128, # 50, p. 16020 - 16021

4-(2-hydroxyethyl)benzoic acid Preparation Products And Raw materials

Raw materials

methyl 4-(2-hydroxyethyl)benzoate Hydrochloric acid Methanol Sodium hydroxide Water

Preparation Products

4-(2-hydroxyethyl)benzoic acid Suppliers

Global( 78)Suppliers
Supplier Tel Email Country ProdList Advantage
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30229 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626 eric@witopchemical.com China 23541 58
Finetech Industry Limited 		+86-27-8746-5837 +8619945049750 info@finetechnology-ind.com China 9629 58
Dayang Chem (Hangzhou) Co.,Ltd. 		+86-0571-88938639 +8617705817739 info@dycnchem.com China 52846 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 sales@sarms4muscle.com China 10473 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49977 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43339 58
R&D Scientific Inc. 		+1-2266000236 sales@rdscientific.com Canada 1864 58
Supplier Advantage
Alchem Pharmtech,Inc. 		58
Career Henan Chemica Co 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
ANHUI WITOP BIOTECH CO., LTD 		58
Finetech Industry Limited 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
GIHI CHEMICALS CO.,LIMITED 		58
LEAPCHEM CO., LTD. 		58
R&D Scientific Inc. 		58

View Lastest Price from 4-(2-hydroxyethyl)benzoic acid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-(2-Hydroxyethyl)benzoic acid pictures 2024-02-13 4-(2-Hydroxyethyl)benzoic acid
46112-46-3
 US $900.00 / g 1g 97 5 Kg R&D Scientific Inc.

4-(2-hydroxyethyl)benzoic acid Spectrum

4-(2-hydroxyethyl)benzoic acid(46112-46-3)1HNMR

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4-(2-Hydroxyethyl)benzoic acid Benzoic acid, 4-(2-hydroxyethyl)- 4-(2-Hydroxyethyl) 4-(2-Hydroxyethyl)benzoic acid 95% 46112-46-3 Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts