Betulonicacid
- CAS No.
- 4481-62-3
- Chemical Name:
- Betulonicacid
- Synonyms
- Betulonic acid;Liquidambaric acid;Prazocin;Prazosine;LiquidaMba;Betulonicaci;Betunolic acid;Lulu Tong acid;Betulinonic acid;Betulonic Acid(P)
- CBNumber:
- CB91075473
- Molecular Formula:
- C30H46O3
- Molecular Weight:
- 454.68
- MDL Number:
- MFCD08459607
- MOL File:
- 4481-62-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 253 °C |
|---|---|
| Boiling point | 548.1±33.0 °C(Predicted) |
| Density | 1.061±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Solid |
| pka | 4.62±0.70(Predicted) |
| color | White to Off-White |
| Major Application | food and beverages |
| InChIKey | SLJTWDNVZKIDAU-SVAFSPIFSA-N |
| SMILES | C1(=O)[C@@]([C@]2([C@](C)(CC1)[C@]1([H])[C@@]([C@]3([C@@](CC1)([H])[C@@]1([C@@](CC[C@H]1C(C)=C)(C(O)=O)CC3)[H])C)(C)CC2)[H])(C)C |
| FDA UNII | 7C1UV6ITF5 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H227-H290 |
| Precautionary statements | P501-P210-P234-P264-P280-P370+P378-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P406-P405 |
| Safety Statements | 24/25 |
| WGK Germany | WGK 3 |
| HS Code | 29389090 |
| Storage Class | 11 - Combustible Solids |
Betulonicacid price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHL83839 | Betulonic acid phyproof? Reference Substance | 4481-62-3 | 10MG | $389 | 2026-04-30 | Buy |
| TCI Chemical | B6085 | Betulonic Acid | 4481-62-3 | 50MG | $150 | 2026-04-30 | Buy |
| TCI Chemical | B6085 | Betulonic Acid | 4481-62-3 | 250MG | $526 | 2026-04-30 | Buy |
| Cayman Chemical | 29765 | Betulonic Acid ≥95% | 4481-62-3 | 5mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 29765 | Betulonic Acid ≥95% | 4481-62-3 | 10mg | $68 | 2026-04-30 | Buy |
Betulonicacid Chemical Properties, Uses, Production
Chemical Properties
Betulin ketoacetic acid in the form of a white crystalline powder is a pentacyclic triterpenoid widely distributed in a variety of plants, and its content in the bark of Betula alba ranges from 0.25 to 2% (in dry form).
Uses
(+)-Betulonic Acid shows potent cytotoxic activities against PC3, MGC-803, Bcap-37, and MCF-7 cell lines.
Definition
ChEBI: Betulonic acid is a triterpenoid. It has a role as an anticoronaviral agent.
Synthesis
472-15-1
4481-62-3
General procedure for the synthesis of 3-oxo-lupin-20(29)-en-28-oic acid from betulinic acid: 1. preparation of Jones' reagent: chromium trioxide (CrO3, 26.72 g) was dissolved in concentrated sulfuric acid (H2SO4, 23 ml) and the solution was subsequently diluted to 100 ml with water. 2. Reaction process: Betulinic acid (BA, 500 mg, 1.09 mmol) was dissolved in a solvent mixture of dichloromethane (CH2Cl2, 12 ml) and acetone (12 ml), and Jones reagent (1 ml) was added slowly after cooling. 3. Reaction control: the reaction mixture was stirred at room temperature for 15 min followed by addition of methanol (MeOH, 5 ml) to terminate the reaction. After continued stirring for 10 minutes, the reaction mixture was diluted by adding dichloromethane (CH2Cl2, 20 ml). 4. Post-treatment: The organic layer was washed sequentially with water and saturated sodium chloride (NaCl) solution, dried with anhydrous sodium sulfate (Na2SO4) and subsequently concentrated under vacuum. 5. Purification: the crude product was recrystallized three times in methanol (MeOH) to give 3-oxo lupin-20(29)-en-28-oic acid (462 mg, 93% yield) as a white solid.
IC 50
Plasmodium; HSV-1
References
[1] Phytochemistry, 1998, vol. 49, # 3, p. 709 - 717
[2] Journal of Asian Natural Products Research, 2014, vol. 16, # 1, p. 34 - 42
[3] Chinese Chemical Letters, 2015, vol. 26, # 6, p. 759 - 762
[4] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3122 - 3134
[5] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 240 - 248
Betulonicacid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Spring & Autumn Biological Engineering Co., Ltd. | 17388075642 13815430202 | sale02@cqherb.com | China | 261 | 59 |
| Wuhan Zhongzhicheng Biotechnology Co., Ltd. | 13628624121 13628604890 | 1205052329@qq.com | China | 9955 | 58 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6744 | 52 |
| Sichuan Kulinan Technology Co., Ltd | 400-1166-196 18981987031 | cdhxsj@163.com | China | 11674 | 57 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4765 | 58 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Chengdu Climax Biotech Co., Ltd. | 028-83311324 1278112614 | climaxbiotech@gmail.com | China | 925 | 58 |
View Latest Price from Betulonicacid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-02 | Betulonic acid
4481-62-3
|
$48.00-127.00 | 99.70% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-03-20 | Betulonicacid
4481-62-3
|
$10.00 | 100KG | 99% | 100 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2024-04-22 | Betulonic acid
4481-62-3
|
$1.00 | 1KG | 99.91% | 200000 | Ouhuang Engineering Materials (Hubei) Co., Ltd |
-
- Betulonic acid
4481-62-3
- $48.00-127.00
- 99.70%
- TargetMol Chemicals Inc.
-
- Betulonicacid
4481-62-3
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- Betulonic acid
4481-62-3
- $1.00
- 99.91%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
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