3-Chlorophenacyl bromide
- CAS No.
- 41011-01-2
- Chemical Name:
- 3-Chlorophenacyl bromide
- Synonyms
- 2-BROMO-1-(3-CHLOROPHENYL)ETHAN-1-ONE;2-bromo-1-(3-chlorophenyl)ethanone;BUTTPARK 41\03-60;Tuloterol Impurity 9.;CHLOROPHENACYL BROMIDE;Tulobuterol Impurity 9;Cenobamate Impurity 24;Tulobuterol Impurity 25;m-Chlorophenacyl bromide;3-Chlorophenacyl bromide
- CBNumber:
- CB9128776
- Molecular Formula:
- C8H6BrClO
- Molecular Weight:
- 233.49
- MDL Number:
- MFCD00792669
- MOL File:
- 41011-01-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 39 °C |
|---|---|
| Boiling point | 122-124℃ |
| Density | 1.598±0.06 g/cm3(Predicted) |
| Flash point | 110 °C |
| storage temp. | 2-8°C |
| form | Solid |
| Appearance | Off-white to yellow Solid |
| Sensitive | Lachrymatory |
| InChI | 1S/C8H6BrClO/c9-5-8(11)6-2-1-3-7(10)4-6/h1-4H,5H2 |
| InChIKey | KJVRURZDIOVSSQ-UHFFFAOYSA-N |
| SMILES | Clc1cccc(c1)C(=O)CBr |
| CAS DataBase Reference | 41011-01-2(CAS DataBase Reference) |
| FDA UNII | N62718DTBS |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280a-P304+P340-P405-P501a-P261-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | C,Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-39 | |||||||||
| RIDADR | UN 3335 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive/Lachrymatory/Keep Cold | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 9 | |||||||||
| HS Code | 2914790090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| Hazardous Substances Data | 41011-01-2(Hazardous Substances Data) | |||||||||
| Limited Quantities | 1 Kg (2.2 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
3-Chlorophenacyl bromide price More Price(64)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 672823 | 2-Bromo-3′-chloroacetophenone 97% | 41011-01-2 | 1g | $51.7 | 2023-01-07 | Buy |
| Sigma-Aldrich | 672823 | 2-Bromo-3′-chloroacetophenone 97% | 41011-01-2 | 5g | $190 | 2023-01-07 | Buy |
| AstaTech | 57570 | 3'-CHLOROPHENACYL BROMIDE 97% | 41011-01-2 | 5G | $33 | 2026-04-30 | Buy |
| Activate Scientific | AS21227 | 2-Bromo-3`-chloroacetophenone 97% | 41011-01-2 | 1g | $22 | 2026-06-04 | Buy |
| Activate Scientific | AS21227 | 2-Bromo-3`-chloroacetophenone 97% | 41011-01-2 | 5g | $37 | 2026-06-04 | Buy |
3-Chlorophenacyl bromide Chemical Properties, Uses, Production
Uses
2-Bromo-3'-chloroacetophenone acts as a Substrate used in a one-step preparation of symmetrical 1,4-diketones in the presence of Zn-I2.
Synthesis
99-02-5
41011-01-2
Molecular sieve-dried 3-chloroacetophenone (154.6 g, 1 mol) was added to a four-necked flask with anhydrous methanol (310 mL) under nitrogen protection. Bromine (158.2 g, 0.99 mol) was slowly added dropwise under continuous stirring in the temperature range of 30 °C to 45 °C. The dropwise addition was controlled to be completed within 1 h. The reaction was carried out in a controlled manner. After the dropwise addition was completed, the reaction mixture was kept at the same temperature and stirring was continued for 10 minutes. Subsequently, water (160 g) was added and the reaction solution was cooled to -10°C to promote crystal precipitation. The precipitate was collected by filtration to give 250 g of crude product. The crude product was dissolved in heptane (750 g), washed twice sequentially with water (200 g) and the organic phase was dried with anhydrous magnesium sulfate. The desiccant was removed by filtration, and the filtrate was concentrated to give 212.5 g of 2-bromo-3-chloroacetophenone in 91.0% yield, and no impurities were detected.
References
[1] Tetrahedron, 1992, vol. 48, # 1, p. 67 - 78
[2] Journal of Medicinal Chemistry, 1992, vol. 35, # 16, p. 3045 - 3049
[3] Patent: US5717116, 1998, A
[4] Patent: US5831132, 1998, A
[5] Patent: EP2280000, 2011, A1. Location in patent: Page/Page column 40-41
3-Chlorophenacyl bromide Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Yaoling Pharmaceutical Technology Partnership (Limited Partnership) | 400-6181121 18616383988 | edison.li@townyuan.com | China | 4763 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| ZhengZhou HuaWen Chemical Co.Ltd | 0370-2785118 17550508557 | 675141927@qq.com | China | 3201 | 55 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
View Latest Price from 3-Chlorophenacyl bromide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | 3-CHLOROPHENACYL BROMIDE
41011-01-2
|
1KG | 99% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2019-07-06 | 3-Chlorophenacyl Bromide
41011-01-2
|
$7.00 | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- 3-CHLOROPHENACYL BROMIDE
41011-01-2
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
-
- 3-Chlorophenacyl Bromide
41011-01-2
- $7.00
- 99%
- Career Henan Chemical Co
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