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2-Bromo-2'-chloroacetophenone

2-Bromo-2'-chloroacetophenone structure

CAS No.: 5000-66-8

Chemical Name:: 2-Bromo-2'-chloroacetophenone

Synonyms: 2-BROMO-1-(2-CHLOROPHENYL)ETHAN-1-ONE;2-CHLOROPHENACYL BROMIDE;)-1-ethanone;2-Bromo-1-(2-chL;BUTTPARK 41\03-52;AKOS BBS-00003974;Tuloterol Impurity 3;Tulobuterol Impurity 1;Tulobuterol Impurity N1;o-Chlorophenacyl bromide

CBNumber:: CB6129707

Molecular Formula:: C8H6BrClO

Molecular Weight:: 233.49

MDL Number:: MFCD00832993

MOL File:: 5000-66-8.mol

MSDS File:: SDS

Last updated:2026-05-28 02:06:03

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2-Bromo-2'-chloroacetophenone Properties

Boiling point	105 °C1 mm Hg(lit.)
Density	1.602 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5900(lit.)
Flash point	>230 °F
storage temp.	2-8°C
solubility	Acetone, Chloroform, Ethyl Acetate, Methanol
form	Liquid
Specific Gravity	1.602
color	Colorless to pale yellow
Sensitive	Lachrymatory
InChI	InChI=1S/C8H6BrClO/c9-5-8(11)6-3-1-2-4-7(6)10/h1-4H,5H2
InChIKey	WZWWEVCLPKAQTA-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=CC=C1Cl)CBr
CAS DataBase Reference	5000-66-8(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

Safety Statements

26-36/37/39-45

RIDADR

UN 2922 8/PG 2

WGK Germany

Hazard Note

Corrosive/Lachrymatory/Keep Cold

HazardClass

PackingGroup

HS Code

29143900

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Skin Corr. 1B

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	1
3		0

2-Bromo-2'-chloroacetophenone price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	594482	2-Bromo-2′-chloroacetophenone 95%	5000-66-8	1g	$72.9	2026-04-30	Buy
Sigma-Aldrich	594482	2-Bromo-2′-chloroacetophenone 95%	5000-66-8	5g	$275	2026-04-30	Buy
TRC	TRC-C365034-1G	2’-Chloro-2-bromoacetophenone	5000-66-8	1g	$72	2026-06-03	Buy
Biosynth	FC20014	2'-Chloro-2-bromoacetophenone	5000-66-8	5g	$900	2026-06-04	Buy
Biosynth	FC20014	2'-Chloro-2-bromoacetophenone	5000-66-8	50g	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
594482	1g	$72.9	Buy
594482	5g	$275	Buy
TRC-C365034-1G	1g	$72	Buy
FC20014	5g	$900	Buy
FC20014	50g	$900	Buy

2-Bromo-2'-chloroacetophenone Chemical Properties, Uses, Production

Chemical Properties

Colourless Liquid

Uses

2’-Chloro-2-bromoacetophenone (cas# 5000-66-8) is a compound useful in organic synthesis.

Preparation

2-Bromo-2'-chloroacetophenone can be prepared by bromination of o-chloroacetophenone.

Hazard

2-Bromo-2'-chloroacetophenone has acute oral toxicity,it causes skin corrosion/irritation nad serious eye damage/eye irritation.

Synthesis

2142-68-9

5000-66-8

The general procedure for the synthesis of 2-bromo-2'-chloroacetophenone from o-chloroacetophenone is as follows: in a reaction system, 1.2 g (10 mmol) of o-chloroacetophenone 1a was mixed and stirred with 0.121 g (0.5 mmol) of Cu(NO3)2-3H2O while an oxygen bulb (ca. 0.5-1 L) was attached. Subsequently, an aqueous 8 mol/L hydrobromic acid solution (1.5 mL, 12 mmol) was slowly added dropwise to the mixture. The reaction mixture was stirred continuously at 70 °C and the reaction progress was monitored by TLC or GC. After completion of the reaction, the mixture was extracted with CH2Cl2. The organic extract was washed sequentially with 5% sodium sulfite solution, saturated sodium bicarbonate solution and water and finally dried with anhydrous magnesium sulfate. The solvent was removed under vacuum and the residue was purified by column chromatography (silica gel as stationary phase, petroleum ether/dichloromethane 3:1 v/v/v) to afford the target product 2-bromo-2'-chloroacetophenone (2a) in a yield of 1.81 g in 91%.

References

[1] Synthetic Communications, 2016, vol. 46, # 2, p. 165 - 168
[2] Patent: US2004/44057, 2004, A1
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 2, p. 692 - 702
[4] Tetrahedron, 1998, vol. 54, # 43, p. 13059 - 13072
[5] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195

2-Bromo-2'-chloroacetophenone synthesis

Synthesis of 2-Bromo-2'-chloroacetophenone from 2'-Chloroacetophenone

2-Bromo-2'-chloroacetophenone Preparation Products And Raw materials

Raw materials

2'-Chloroacetophenone Bromine Benzene, 1-(2-bromoethynyl)-2-chloro- 2-Chlorostyrene 1-Chloro-2-ethynylbenzene

1-(2-Chlorophenyl)-1-ethanol 2-Chlorobenzoyl chloride Carbamimidothioic acid Chlorobenzene

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Preparation Products

1-(2-Chlorophenyl)-2-bromoethanol 3-(2-Chloro-phenyl)-isoxazol-5-ylamine Clorprenaline Tulobuterol Impurity 2-Chlorobenzoylacetonitrile

4-(2-Chlorophenyl)-2-Methylthiazole N-Allyl-4-(2-Chlorophenyl)Thiazol-2-Amine

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2-Bromo-2'-chloroacetophenone Suppliers

Global Suppliers ( 334)

Supplier	Tel	Email	Country	ProdList	Advantage
NANJING WEDO PHARMATECH CO.,LTD.	15189836218	wedo-chem@huawe.com	China	240	58
Huadong Microbiology Co., Ltd.	15858880160	dingya@eastchinapharm.com	China	87	58
Beijing Hope International Pharmaceutical Technology Development Co., Ltd	01067886402 15600038801	wuhangjin@hopelife.cn	China	19	58
Cdreamlab (Hubei) Technology Co., LTD	18062399888; 18062399888	service@cdreamlab.com	China	129	58
Jiangsu Baiaoxinkang Pharmaceutical Technology Co. , Ltd.	18015077019 18015077019	jwang@bioscenepharma.com	China	105	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61

Supplier	Advantage
NANJING WEDO PHARMATECH CO.,LTD.	58
Huadong Microbiology Co., Ltd.	58
Beijing Hope International Pharmaceutical Technology Development Co., Ltd	58
Cdreamlab (Hubei) Technology Co., LTD	58
Jiangsu Baiaoxinkang Pharmaceutical Technology Co. , Ltd.	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
Energy Chemical	61

View Latest Price from 2-Bromo-2'-chloroacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-14	2-Bromo-2'-chloroacetophenone 5000-66-8	$10.00	1ASSAYS	99%	1 ton	RongNa Biotechnology Co.,Ltd
2026-09-14	2-Bromo-2'-chloroacetophenone 5000-66-8	$66.00-99.00		99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-09-11	2-Bromo-2'-chloroacetophenone 5000-66-8		1KG	98.0%	10kg/month	WUHAN FORTUNA CHEMICAL CO., LTD

2-Bromo-2'-chloroacetophenone
5000-66-8
$10.00
99%
RongNa Biotechnology Co.,Ltd

2-Bromo-2'-chloroacetophenone
5000-66-8
$66.00-99.00
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

2-Bromo-2'-chloroacetophenone
5000-66-8
$0.00
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

2-Bromo-2'-chloroacetophenone Spectrum

2-Bromo-2'-chloroacetophenone(5000-66-8)¹HNMR 2-Bromo-2'-chloroacetophenone(5000-66-8)FT-IR

5000-66-8 (2-Bromo-2'-chloroacetophenone) Related Search:

2-Bromoacetophenone 4'-Hydroxyacetophenone 4-Nitroacetophenone 4'-Bromoacetophenone Acetophenone

2',6'-Dichloroacetophenone 2-Chlorophenol Dichloroacetonitrile 2-Chlorobenzoic acid 2-Chlorobenzaldehyde

2',4'-Dichloroacetophenone 3'-Chloroacetophenone 4'-Chloroacetophenone alpha-Bromo-2-chlorophenylacetic acid 3-Nitroacetophenone

3-Aminoacetophenone 2,2',4'-Trichloroacetophenone 2-Chlorophenylacetic acid

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2-Bromo-1-(-2-chlorophenyl)ethanone -Bromo-2-chloroacetophenone 2-CHLOROPHENACYL BROMIDE 2-BROMO-1-(2-CHLOROPHENYL)-1-ETHANONE 2-BROMO-2'-CHLORO ACETOPHENONE 2'-CHLORO-2-BROMOACETOPHENONE 2-CHLORO-2'-BROMOACETOPHENONE AKOS BBS-00003974 BUTTPARK 41\03-52 2-Chlorophenacyl bromide, tech o-Chlorophenacyl bromide 2'-Chloro-α-bromoacetophenone 2-Bromo-1-(2-chlorophenyl)ethan-1-one , Tech. 2-Bromo-2'-chloroacetophenone, 2-Bromo-1-(2-chlorophenyl)ethan-1-one 1-(2-broMophenyl)-2-chloroethan-1-one BroMoMethyl 2-Chlorophenyl Ketone Acetophenone, 2-broMo-2'-chloro- (6CI,7CI,8CI) Ethanone,2-broMo-1-(2-chlorophenyl)- 2-BroMo-1-(2-chlorophenyl)-1-ethanone, >95% 2-Bromo-2'-chloroacetophenone 95% Tulobuterol Impurity 1 2-Bromo-1-(2-chL )-1-ethanone 2-BROMO-1-(2-CHLOROPHENYL)-1-ETHANON α-Bromo-o-chloro acetophenone α-Bromo-2-chloroacetophenone 2-Bromo-2'-chloroacetophenone 2'-Chlorophenacyl bromide Tulobuterol Impurity N1 Tuloterol Impurity 3 -Bromo-2-chloroacetophenone 2-BROMO-1-(2-CHLOROPHENYL)ETHAN-1-ONE 5000-66-8 18366-40-4 ClC6H4COCH2Br C8H6OBrCl Organic Building Blocks Ketones C7 to C8 Carbonyl Compounds Building Blocks Aromatics C7 to C8 Carbonyl Compounds Ketones