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2-Bromo-2'-chloroacetophenone

2-Bromo-2'-chloroacetophenone structure

CAS No.: 5000-66-8

Chemical Name:: 2-Bromo-2'-chloroacetophenone

Synonyms: 2-BROMO-1-(2-CHLOROPHENYL)ETHAN-1-ONE;2-CHLOROPHENACYL BROMIDE;)-1-ethanone;2-Bromo-1-(2-chL;BUTTPARK 41\03-52;AKOS BBS-00003974;Tuloterol Impurity 3;Tulobuterol Impurity 1;Tulobuterol Impurity N1;o-Chlorophenacyl bromide

CBNumber:: CB6129707

Molecular Formula:: C8H6BrClO

Molecular Weight:: 233.49

MDL Number:: MFCD00832993

MOL File:: 5000-66-8.mol

MSDS File:: SDS

Last updated:2026-01-19 13:09:01

Product description	Number	Pack Size	Price
2-Bromo-2′-chloroacetophenone 95%	594482	1g	$68.5
2-Bromo-2′-chloroacetophenone 95%	594482	5g	$258
2’-Chloro-2-bromoacetophenone	C365034	5g	$145
2’-Chloro-2-bromoacetophenone	C365034	25g	$360
2'-Chloro-2-bromoacetophenone	FC20014	50g	$500
More product size

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2-Bromo-2'-chloroacetophenone Properties

Boiling point	105 °C1 mm Hg(lit.)
Density	1.602 g/mL at 25 °C(lit.)
refractive index	n20/D 1.5900(lit.)
Flash point	>230 °F
storage temp.	2-8°C
solubility	Acetone, Chloroform, Ethyl Acetate, Methanol
form	Liquid
Specific Gravity	1.602
color	Colorless to pale yellow
Sensitive	Lachrymatory
InChI	InChI=1S/C8H6BrClO/c9-5-8(11)6-3-1-2-4-7(6)10/h1-4H,5H2
InChIKey	WZWWEVCLPKAQTA-UHFFFAOYSA-N
SMILES	C(=O)(C1=CC=CC=C1Cl)CBr
CAS DataBase Reference	5000-66-8(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

PPE

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

Safety Statements

26-36/37/39-45

RIDADR

UN 2922 8/PG 2

WGK Germany

Hazard Note

Corrosive/Lachrymatory/Keep Cold

HazardClass

PackingGroup

HS Code

29143900

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials

Hazard Classifications

Skin Corr. 1B

Limited Quantities

1.0 L (0.3 gallons) (liquid) or 1 Kg (2.2 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	1
3		0

2-Bromo-2'-chloroacetophenone price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	594482	2-Bromo-2′-chloroacetophenone 95%	5000-66-8	1g	$68.5	2025-07-31	Buy
Sigma-Aldrich	594482	2-Bromo-2′-chloroacetophenone 95%	5000-66-8	5g	$258	2025-07-31	Buy
TRC	C365034	2’-Chloro-2-bromoacetophenone	5000-66-8	5g	$145	2021-12-16	Buy
TRC	C365034	2’-Chloro-2-bromoacetophenone	5000-66-8	25g	$360	2021-12-16	Buy
Biosynth Carbosynth	FC20014	2'-Chloro-2-bromoacetophenone	5000-66-8	50g	$500	2021-12-16	Buy

Product number	Packaging	Price	Buy
594482	1g	$68.5	Buy
594482	5g	$258	Buy
C365034	5g	$145	Buy
C365034	25g	$360	Buy
FC20014	50g	$500	Buy

2-Bromo-2'-chloroacetophenone Chemical Properties,Uses,Production

Chemical Properties

Colourless Liquid

Uses

2’-Chloro-2-bromoacetophenone (cas# 5000-66-8) is a compound useful in organic synthesis.

Preparation

2-Bromo-2'-chloroacetophenone can be prepared by bromination of o-chloroacetophenone.

Hazard

2-Bromo-2'-chloroacetophenone has acute oral toxicity,it causes skin corrosion/irritation nad serious eye damage/eye irritation.

Synthesis

2142-68-9

5000-66-8

The general procedure for the synthesis of 2-bromo-2'-chloroacetophenone from o-chloroacetophenone is as follows: in a reaction system, 1.2 g (10 mmol) of o-chloroacetophenone 1a was mixed and stirred with 0.121 g (0.5 mmol) of Cu(NO3)2-3H2O while an oxygen bulb (ca. 0.5-1 L) was attached. Subsequently, an aqueous 8 mol/L hydrobromic acid solution (1.5 mL, 12 mmol) was slowly added dropwise to the mixture. The reaction mixture was stirred continuously at 70 °C and the reaction progress was monitored by TLC or GC. After completion of the reaction, the mixture was extracted with CH2Cl2. The organic extract was washed sequentially with 5% sodium sulfite solution, saturated sodium bicarbonate solution and water and finally dried with anhydrous magnesium sulfate. The solvent was removed under vacuum and the residue was purified by column chromatography (silica gel as stationary phase, petroleum ether/dichloromethane 3:1 v/v/v) to afford the target product 2-bromo-2'-chloroacetophenone (2a) in a yield of 1.81 g in 91%.

References

[1] Synthetic Communications, 2016, vol. 46, # 2, p. 165 - 168
[2] Patent: US2004/44057, 2004, A1
[3] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 2, p. 692 - 702
[4] Tetrahedron, 1998, vol. 54, # 43, p. 13059 - 13072
[5] Tetrahedron Letters, 2012, vol. 53, # 2, p. 191 - 195

2-Bromo-2'-chloroacetophenone synthesis

Synthesis of 2-Bromo-2'-chloroacetophenone from 2'-Chloroacetophenone

2-Bromo-2'-chloroacetophenone Preparation Products And Raw materials

Raw materials

2'-Chloroacetophenone Bromine Benzene, 1-(2-bromoethynyl)-2-chloro- 2-Chlorostyrene 1-CHLORO-2-ETHYNYLBENZENE

1-(2-Chlorophenyl)-1-ethanol 2-Chlorobenzoyl chloride Carbamimidothioic acid Chlorobenzene

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Preparation Products

1-(2-CHLOROPHENYL)-2-BROMOETHANOL 3-(2-CHLORO-PHENYL)-ISOXAZOL-5-YLAMINE Clorprenaline Tulobuterol Impurity 2-CHLOROBENZOYLACETONITRILE

4-(2-Chlorophenyl)-2-Methylthiazole N-Allyl-4-(2-Chlorophenyl)Thiazol-2-Amine

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2-Bromo-2'-chloroacetophenone Suppliers

Global( 328)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Paron Technology Co., Ltd	+86-13770590702 +86-13770590702	arthur@parontek.com	China	234	58
Hebei Chuanghai Biotechnology Co., Ltd	+8615350571055	Sibel@chuanghaibio.com	China	8753	58
RongNa Biotechnology Co.,Ltd	+86-86-13583358881 +8618560316533	Brad@rongnabiotech.com	China	3378	58
Shanghai Joiny Pharmaceutical Co.,LTD	+86-13681955282 +86-13681955282;	gyd@joiny-pharma.com	China	402	58
Chengdu Aupone Pharmaceutical Co.Ltd.	+86-28-+86-28-87843998-6060-6060 +8618631098571	lijiaqi@aupone.com	China	55	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	+86-15350851019; +8615350851019	admin@86-ss.com	China	999	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29735	60
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58

Supplier	Advantage
Nanjing Paron Technology Co., Ltd	58
Hebei Chuanghai Biotechnology Co., Ltd	58
RongNa Biotechnology Co.,Ltd	58
Shanghai Joiny Pharmaceutical Co.,LTD	58
Chengdu Aupone Pharmaceutical Co.Ltd.	58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD	58
Capot Chemical Co.,Ltd.	60
Nanjing ChemLin Chemical Industry Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58

View Lastest Price from 2-Bromo-2'-chloroacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-02-19	2-Bromo-2'-chloroacetophenone 5000-66-8	US $10.00 / ASSAYS	1ASSAYS	99%	1 ton	RongNa Biotechnology Co.,Ltd
2026-02-13	2-Bromo-2'-chloroacetophenone 5000-66-8	US $0.00 / KG	1KG	98.0%	10kg/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-02-11	2-Bromo-2'-chloroacetophenone 5000-66-8	US $99.00-66.00 / kg	0.0010000000474974513kg	99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

2-Bromo-2'-chloroacetophenone
5000-66-8
US $10.00 / ASSAYS
99%
RongNa Biotechnology Co.,Ltd

2-Bromo-2'-chloroacetophenone
5000-66-8
US $0.00 / KG
98.0%
WUHAN FORTUNA CHEMICAL CO., LTD

2-Bromo-2'-chloroacetophenone
5000-66-8
US $99.00-66.00 / kg
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

2-Bromo-2'-chloroacetophenone Spectrum

2-Bromo-2'-chloroacetophenone(5000-66-8)¹HNMR 2-Bromo-2'-chloroacetophenone(5000-66-8)FT-IR

5000-66-8(2-Bromo-2'-chloroacetophenone)Related Search:

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2',4'-Dichloroacetophenone 3'-Chloroacetophenone 4'-Chloroacetophenone alpha-Bromo-2-chlorophenylacetic acid 3-Nitroacetophenone

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2-Bromo-1-(-2-chlorophenyl)ethanone -Bromo-2-chloroacetophenone 2-CHLOROPHENACYL BROMIDE 2-BROMO-1-(2-CHLOROPHENYL)-1-ETHANONE 2-BROMO-1-(2-CHLOROPHENYL)ETHAN-1-ONE 2-BROMO-2'-CHLORO ACETOPHENONE 2'-CHLORO-2-BROMOACETOPHENONE 2-CHLORO-2'-BROMOACETOPHENONE AKOS BBS-00003974 BUTTPARK 41\03-52 2-Chlorophenacyl bromide, tech o-Chlorophenacyl bromide 2'-Chloro-α-bromoacetophenone 2-Bromo-1-(2-chlorophenyl)ethan-1-one , Tech. 2-Bromo-2'-chloroacetophenone, 2-Bromo-1-(2-chlorophenyl)ethan-1-one 1-(2-broMophenyl)-2-chloroethan-1-one BroMoMethyl 2-Chlorophenyl Ketone Acetophenone, 2-broMo-2'-chloro- (6CI,7CI,8CI) Ethanone,2-broMo-1-(2-chlorophenyl)- 2-BroMo-1-(2-chlorophenyl)-1-ethanone, >95% 2-Bromo-2'-chloroacetophenone 95% Tulobuterol Impurity 1 2-Bromo-1-(2-chL )-1-ethanone 2-BROMO-1-(2-CHLOROPHENYL)-1-ETHANON α-Bromo-o-chloro acetophenone α-Bromo-2-chloroacetophenone 2-Bromo-2'-chloroacetophenone 2'-Chlorophenacyl bromide Tulobuterol Impurity N1 Tuloterol Impurity 3 -Bromo-2-chloroacetophenone 5000-66-8 18366-40-4 ClC6H4COCH2Br C8H6OBrCl Organic Building Blocks Ketones C7 to C8 Carbonyl Compounds Building Blocks Aromatics C7 to C8 Carbonyl Compounds Ketones