2-Aminopyrimidine-5-carboxylic acid
- CAS No.
- 3167-50-8
- Chemical Name:
- 2-Aminopyrimidine-5-carboxylic acid
- Synonyms
- ASISCHEM C63548;2-Aminopyrimidine-5-carboxyL;2-Aminopyrimidin-5-carboxylic acid;2-AMINOPYRIMIDINE-5-CARBOXYLIC ACID;2-AMino-5-pyriMidinecarboxylic acid;2-Aminopyrimidine-5-carboxylicacid95%;5-Pyrimidinecarboxylic acid, 2-amino-;2-Aminopyrimidine-5-carboxylic acid ,97%;2-Aminopyrimidine-5-carboxylic acid USP/EP/BP;5-Pyrimidinecarboxylic acid, 2-amino- (7CI,8CI,9CI)
- CBNumber:
- CB9330403
- Molecular Formula:
- C5H5N3O2
- Molecular Weight:
- 139.11
- MDL Number:
- MFCD05864791
- MOL File:
- 3167-50-8.mol
- MSDS File:
- SDS
| Melting point | >300 °C |
|---|---|
| Boiling point | 474.6±37.0 °C(Predicted) |
| Density | 1.533±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| pka | 4.19±0.10(Predicted) |
| Appearance | White to yellow Solid |
| InChI | InChI=1S/C5H5N3O2/c6-5-7-1-3(2-8-5)4(9)10/h1-2H,(H,9,10)(H2,6,7,8) |
| InChIKey | CBRLWSXYXSFYSP-UHFFFAOYSA-N |
| SMILES | C1(N)=NC=C(C(O)=O)C=N1 |
| CAS DataBase Reference | 3167-50-8(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 36/37-24/25-22 |
| HS Code | 29335990 |
2-Aminopyrimidine-5-carboxylic acid price More Price(54)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 20118 | 2-AMINOPYRIMIDINE-5-CARBOXYLIC ACID 97% | 3167-50-8 | 1G | $38 | 2026-04-30 | Buy |
| AstaTech | 20118 | 2-AMINOPYRIMIDINE-5-CARBOXYLIC ACID 97% | 3167-50-8 | 5G | $98 | 2026-04-30 | Buy |
| AstaTech | 20118 | 2-AMINOPYRIMIDINE-5-CARBOXYLIC ACID 97% | 3167-50-8 | 25G | $449 | 2026-04-30 | Buy |
| Activate Scientific | AS30196 | 2-Aminopyrimidine-5-carboxylic acid 97% | 3167-50-8 | 1g | $29 | 2026-06-04 | Buy |
| Activate Scientific | AS30196 | 2-Aminopyrimidine-5-carboxylic acid 97% | 3167-50-8 | 5g | $78 | 2026-06-04 | Buy |
2-Aminopyrimidine-5-carboxylic acid Chemical Properties,Uses,Production
Reactivity Profile
Decarboxylative Csingle bondC cross-couplings of 2-aminopyrimidine-5-carboxylic acids under a Pd/Ag-based catalytic system opens a new platform for introducing diverse C5 substituents. The reaction methods proceeded efficiently with various acids and the coupling partners of aryl iodides, alkenes, bromoalkynes, and azoles.
Synthesis
308348-93-8
3167-50-8
General procedure for the synthesis of 2-aminopyrimidine-5-carboxylic acid from methyl 2-aminopyrimidine-5-carboxylate: methyl 2-aminopyrimidine-5-carboxylate (300 mg, 2.0 mmol) was dissolved in methanol (5 mL) containing a small amount of water. Lithium hydroxide (122 mg, 5.1 mmol) was added to the solution and the reaction mixture was subsequently stirred at 60 °C overnight. Upon completion of the reaction, the mixture was concentrated under reduced pressure, and the residue was diluted with water and the pH was adjusted to 4 with 1 M HCl solution.At this point, 2-aminopyrimidine-5-carboxylic acid precipitated as a white solid, and the product was collected by filtration under vacuum to give 244 mg in 90% yield. The product was characterized by 1H NMR (DMSO-d6): δ 12.73 (1H, broad peak), 8.63 (2H, single peak), 7.44 (2H, broad peak).
References
[1] Ngoc Son Le Pham . “Decarboxylative cross-couplings of 2-aminopyrimidine-5-carboxylic acids.” Tetrahedron 74 28 (2018): Pages 3843-3851.
2-Aminopyrimidine-5-carboxylic acid Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Qihuan Pharmaceutical Technology Co., Ltd. | 132-132-9536-3019-3019 15069072278 | 1427450352@qq.com | China | 14 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Scientia Pharmaceutical Technology Co., Ltd. | 21-21-54301573 13917723525 | sales@scientiapharm.com | China | 260 | 62 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Lastest Price from 2-Aminopyrimidine-5-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-08 | 2-Aminopyrimidine-5-carboxylic acid
3167-50-8
|
$1.00 | 1Kg | 98% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 2-Aminopyrimidine-5-carboxylic acid
3167-50-8
|
$8.00 | 1kg | 99% | 10MT | Career Henan Chemical Co |
-
- 2-Aminopyrimidine-5-carboxylic acid
3167-50-8
- $1.00
- 98%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Aminopyrimidine-5-carboxylic acid
3167-50-8
- $8.00
- 99%
- Career Henan Chemical Co
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