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Methyl 3,3-dimethoxypropionate

Methyl 3,3-dimethoxypropionate structure

CAS No.: 7424-91-1

Chemical Name:: Methyl 3,3-dimethoxypropionate

Synonyms: Methyl 3,3-dimethoxypropanoate;DMPM;3,3-DIMETHOXYPROPIONATE;THYL 3,3-DIMETHOXYPROPIONATE;Methyl ,-Dimethoxypropionate;Mthyl 3,3-dimethoxypropionate;Methy 3,3-dimethoxypropionate;Methyl β,β-Dimethoxypropionate;Methyl 3,3-dimethoxypropionate;Methyl3,3-Dimethoxypropionate>

CBNumber:: CB3221365

Molecular Formula:: C6H12O4

Molecular Weight:: 148.16

MDL Number:: MFCD00010650

MOL File:: 7424-91-1.mol

MSDS File:: SDS

Last updated:2026-09-12 18:51:50

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Methyl 3,3-dimethoxypropionate Properties

Boiling point	77 °C/20 mmHg (lit.)
Density	1.045 g/mL at 25 °C (lit.)
refractive index	n20/D 1.41(lit.)
Flash point	150 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
form	Liquid
color	Clear colorless
BRN	1561517
InChI	InChI=1S/C6H12O4/c1-8-5(7)4-6(9-2)10-3/h6H,4H2,1-3H3
InChIKey	SMCVPMKCDDNUCQ-UHFFFAOYSA-N
SMILES	C(OC)(=O)CC(OC)OC
CAS DataBase Reference	7424-91-1(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H227

Precautionary statements

P210e-P280a-P370+P378a-P501a-P210-P280-P370+P378-P403+P235-P501

PPE

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-24/25

WGK Germany

HS Code

29189900

Storage Class

10 - Combustible liquids

NFPA 704

	1
2		0

Methyl 3,3-dimethoxypropionate price More Price(58)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	288322	Methyl 3,3-dimethoxypropionate 97%	7424-91-1	25g	$99.6	2026-04-30	Buy
Sigma-Aldrich	288322	Methyl 3,3-dimethoxypropionate 97%	7424-91-1	5g	$33.7	2023-06-20	Buy
TCI Chemical	D1858	Methyl 3,3-Dimethoxypropionate >98.0%(GC)	7424-91-1	25g	$105	2026-04-30	Buy
TCI Chemical	D1858	Methyl 3,3-Dimethoxypropionate >98.0%(GC)	7424-91-1	500g	$500	2021-12-16	Buy
Usbiological	281885	Methyl 3,3-dimethoxypropionate Asreported	7424-91-1	10g	$326	2026-06-03	Buy

Product number	Packaging	Price	Buy
288322	25g	$99.6	Buy
288322	5g	$33.7	Buy
D1858	25g	$105	Buy
D1858	500g	$500	Buy
281885	10g	$326	Buy

Methyl 3,3-dimethoxypropionate Chemical Properties, Uses, Production

Preparation

300.0 g of methyl acetate and 16.5 g of sodium methoxide were added to a high-pressure reactor. CO gas was then introduced to a pressure of 3.0 MPa. The reaction temperature was maintained at 60 °C, and the CO pressure was controlled at 3.0 MPa. After the reaction was complete, the solution was transferred to a distillation vessel to remove excess methyl acetate. 131.4 g of a 10% hydrogen chloride methanol solution was slowly added dropwise at a reaction temperature of 65 °C. After post-treatment, concentration, and distillation, 30.6 g of methyl 3,3-dimethoxypropionate was obtained, with a purity of 95.7% and a yield of 66.2%.

Chemical Properties

Clear colorless liquid

Uses

Methyl β,β-Dimethoxypropionate is used as a reactant in the preparation of tetrahydro-β-carboline derivatives as antitumor growth and metastasis agents.

Synthesis Reference(s)

The Journal of Organic Chemistry, 50, p. 4157, 1985 DOI: 10.1021/jo00221a038

General Description

Methyl 3,3-dimethoxypropionate was used in the synthesis of 3-indolyl α,β-unsaturated carbonyl compounds.

Methyl 3,3-dimethoxypropionate synthesis

Synthesis of Methyl 3,3-dimethoxypropionate from Acetyl ketene and Trimethoxymethane

Methyl 3,3-dimethoxypropionate Preparation Products And Raw materials

Raw materials

Dimethyl malonate 1,4-Cyclohexadiene, (1E,4Z)- 2-Pentene, 1,1,5,5-tetramethoxy- 1,1,2,2-Tetramethoxyethane Methyl dimethoxyacetate

Trimethyl 1,3,5-benzenetricarboxylate Methanol acrylic acid methyl ester

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Preparation Products

Methyl 2-formyl-3-oxo-propionate 3-Quinolinecarboxylic acid, 6-broMo-, Methyl ester Cyclopropanol, 1-(2,2-dimethoxyethyl)- 3-Furancarboxylicacid,5-methyl-,methylester(9CI)

Methyl 3,3-dimethoxypropionate Suppliers

Global Suppliers ( 312)

Supplier	Tel	Email	Country	ProdList	Advantage
Jiaxing Jilat Chemical Co. LTD	0573-82813639 15157377625	sales@jlightchem.com	China	165	58
Heze Zhebang Biotechnology Co., Ltd	13173001339（微信） 18765019857	903286878@qq.com	China	38	58
Beijing Holiyang Chemical Co. Ltd.	13718199399	holiyangchem@163.com	China	3271	56
Tai 'an Huanyu Chemical Co., LTD	13176825516; 13176825516	78995114@qq.com	China	79	58
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Jinan Kabotang Biological Technology Co.,Ltd.	0531-61320525 15866703830	figo.gao@foxmail.com	China	7601	58
Dexin chemical (Shandong) Co. , Ltd.	18815338815	dexinhuaxue@163.com	China	152	58
Hubei Paijian Biotechnology Co., Ltd	18164202469 18163347313	1205135340@qq.com	China	116	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Yangzhou Siyu Chemical Co.,Ltd.	0514-87325867	sales@siyuchem.com	China	370	55

Supplier	Advantage
Jiaxing Jilat Chemical Co. LTD	58
Heze Zhebang Biotechnology Co., Ltd	58
Beijing Holiyang Chemical Co. Ltd.	56
Tai 'an Huanyu Chemical Co., LTD	58
Beijing Ouhe Technology Co., Ltd	60
Jinan Kabotang Biological Technology Co.,Ltd.	58
Dexin chemical (Shandong) Co. , Ltd.	58
Hubei Paijian Biotechnology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Yangzhou Siyu Chemical Co.,Ltd.	55

View Latest Price from Methyl 3,3-dimethoxypropionate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-20	METHYL 3,3-DIMETHOXYPROPIONATE 7424-91-1	$10.00	1KG	99%	10 mt	Hebei Chuanghai Biotechnology Co., Ltd
2025-08-20	METHYL 3,3-DIMETHOXYPROPIONATE 7424-91-1		1kg	99.99%	20 tons	Chongqing Soarwin Technology Co., Ltd
2025-03-11	METHYL 3,3-DIMETHOXYPROPIONATE 7424-91-1		1KG	99%	500000kg	Hebei Chuanghai Biotechnology Co., Ltd

METHYL 3,3-DIMETHOXYPROPIONATE
7424-91-1
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

METHYL 3,3-DIMETHOXYPROPIONATE
7424-91-1
99.99%
Chongqing Soarwin Technology Co., Ltd

METHYL 3,3-DIMETHOXYPROPIONATE
7424-91-1
99%
Hebei Chuanghai Biotechnology Co., Ltd

Methyl 3,3-dimethoxypropionate Spectrum

METHYL 3,3-DIMETHOXYPROPIONATE(7424-91-1)MS METHYL 3,3-DIMETHOXYPROPIONATE(7424-91-1)¹HNMR METHYL 3,3-DIMETHOXYPROPIONATE(7424-91-1)¹³CNMR METHYL 3,3-DIMETHOXYPROPIONATE(7424-91-1)IR1 METHYL 3,3-DIMETHOXYPROPIONATE(7424-91-1)Raman

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METHYL FORMYLACETATE DIMETHYLACETAL THYL 3,3-DIMETHOXYPROPIONATE 3,3-DIMETHOXYPROPIONIC ACID METHYL ESTER Propanoic acid, 3,3-dimethoxy-, methyl ester malonaldehydic acid dimethyl acetal methyl ester 3,3-DIMETHOXYPROPIONIC ACID METHYL ESTER 95+% Methyl 3,3-dimethoxypropionate,99% Mthyl 3,3-dimethoxypropionate Methyl 3,3-diMethoxypropionate, 99% 25GR Methyl 3,3-dimethoxypropionate, (Methoxycarbonyl)acetaldehyde dimethyl acetal Methyl 3,3-diMethoxypropionate 97% Methyl 3,3-dimethoxypropionate, >=96% 3,3-DIMETHOXYPROPIONATE Methyl3,3-Dimethoxypropionate> METHYL 3,3-DIMETHOXYPROPIONATE 7424-91-1 Methyl β,β-Dimethoxypropionate Methyl ,-Dimethoxypropionate 3,3-Dimethoxypropionic Acid Methyl Ester?New Methy 3,3-dimethoxypropionate Dimethyl 3,3-Dimethoxypropionate Methyl 3,3-dimethoxypropanoate , Methyl 3,3-dimethoxypropionate DMPM Methyl 3,3-dimethoxypropanoate Methyl 3,3-dimethoxypropionate 7424-91-1 CH3O2CHCH2CO2CH3 C6 to C7 Carbonyl Compounds Building Blocks Organic Building Blocks Esters C6 to C7 Carbonyl Compounds Esters