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GSK3359088

GSK3359088 Structure
GSK3359088 structure
CAS No.
1628830-21-6
Chemical Name:
GSK3359088
Synonyms
EZM2302;CS-2741;GSK3359088;EZM2302 (GSK3359088);EZM 2302, 10 mM in DMSO;EZM2302;EZM-2302;EZM 2302;inhibit,Inhibitor,EZM2302,Histone Methyltransferase,EZM 2302,EZM-2302;Methyl 2-(2-(2-chloro-5-((R)-2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate;Methyl 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-4-pyrimidinyl]-2,7-diazaspiro[3.5]nonane-7-carboxylate;methyl 2-(2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate
CBNumber:
CB93364258
Molecular Formula:
C29H37ClN6O5
Molecular Weight:
585.09
MDL Number:
MFCD31657380
MOL File:
1628830-21-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-14 16:49:18
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GSK3359088 Properties

Boiling point 705.8±60.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO:91.0(Max Conc. mg/mL);155.53(Max Conc. mM)
DMSO:91.0(Max Conc. mg/mL);155.53(Max Conc. mM)
form A solid
pka 13.79±0.20(Predicted)
color White to off-white
InChIKey OWCOTUVKROVONT-HXUWFJFHSA-N
SMILES C1C2(CCN(C(OC)=O)CC2)CN1C1C(C)=C(C2=C(C)ON=C2C)N=C(C2=CC(OC[C@H](O)CNC)=CC=C2Cl)N=1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
NFPA 704
0
2 0

GSK3359088 price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 29954 EZM2302 ≥98% 1628830-21-6 1mg $75 2026-04-30 Buy
Cayman Chemical 29954 EZM2302 ≥98% 1628830-21-6 5mg $351 2026-04-30 Buy
Cayman Chemical 29954 EZM2302 ≥98% 1628830-21-6 10mg $662 2026-04-30 Buy
ChemScene CS-0034242 EZM 2302 99.51% 1628830-21-6 5mg $217 2026-06-04 Buy
ChemScene CS-0034242 EZM 2302 99.51% 1628830-21-6 10mg $325 2026-06-04 Buy
Product number Packaging Price Buy
29954 1mg $75 Buy
29954 5mg $351 Buy
29954 10mg $662 Buy
CS-0034242 5mg $217 Buy
CS-0034242 10mg $325 Buy

GSK3359088 Chemical Properties, Uses, Production

Uses

EZM 2302 is a potent and orally active CARM1 inhibitor with an IC50 value of 6 nM. EZM 2302 shows antiproliferative activity and anti-tumor activity. EZM 2302 inhibits PABP1 and SMB expression[1].

in vivo

EZM 2302 (37.5, 75, 150, 300 mg/kg; p.o.; twice daily for 21 days) shows anti-tumor activity in mouse[1].
Pharmacokinetic Parameters of EZM 2302 in CD-1 mouse and Sprague-Dawley rat[1].

ParametersIV(CD-1 mouse)PO(CD-1 mouse)IV (Sprague-Dawley rat)PO (Sprague-Dawley rat)
Dose (mg/kg)210210
Blood:plasma ratio1.21.22.6ND
Cmax(ng/mL)177113±22.4
Tmax(h)2.002.00
AUC0-last(ng.h/mL)767568352±30.6453±89.3
AUC0-inf(ng.h/mL)772577372±43.3487±102
t1/2(h)4.224.556.21±1.656.64±1.41
Vss(L/kg)6.5335.6±1.30
CL (mL/min/kg) 43.290.5±10.5
Fa*Fg (%)ND80.7
F (%)15.026.2±5.45
CD-1 mouse and Sprague-Dawley rats, 2 mg/kg iv; 10 mg/kg po[1]

References

[1] Drew AE, et al. Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma. Sci Rep. 2017 Dec 21;7(1):17993. DOI:10.1038/s41598-017-18446-z

GSK3359088 Preparation Products And Raw materials

Raw materials

Preparation Products

GSK3359088 Suppliers

Global Suppliers ( 83)
Supplier Tel Email Country ProdList Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 024-88590548 18698872706 757984502@qq.com China 960 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097 info@topbiochem.com China 9509 58
SINO High Goal Chemical Technology Co., Ltd. 021-57646680 18306277365 sunkai@chembiobanksh.com China 2039 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185 sales-cpd@caerulumpharma.com China 3493 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266 China 4859 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8000 62
Amadis Chemical Company Limited 571-89925085 sales@amadischem.com China 131885 58
Medi-tech Bioscientific Co., Ltd. 0519-83246372 13585352506 China 1838 58
Heze Development Zone chuangli Chemical Co., Ltd. 0530-+86-530-529 6766，+86-15666160102 15666160102 info@chuangli-chem.com China 849 55
Supplier Advantage
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 58
Shanghai Topbiochem Technology Co., Ltd 58
SINO High Goal Chemical Technology Co., Ltd. 55
ShangHai Caerulum Pharma Discovery Co., Ltd. 58
Shanghai Lollane Biological Technology Co.,Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60
ShangHai Biochempartner Co.,Ltd 62
Amadis Chemical Company Limited 58
Medi-tech Bioscientific Co., Ltd. 58
Heze Development Zone chuangli Chemical Co., Ltd. 55

View Latest Price from GSK3359088 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
EZM 2302 pictures 2026-08-25 EZM 2302
1628830-21-6
 $2.00-5.00 1kg 99% 100kg ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
EZM 2302 pictures 2026-07-14 EZM 2302
1628830-21-6
 $68.00-247.00 97.47% 10g TargetMol Chemicals Inc.
  • EZM 2302 pictures
  • EZM 2302
    1628830-21-6
  • $2.00-5.00
  • 99%
  • ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
  • EZM 2302 pictures
  • EZM 2302
    1628830-21-6
  • $68.00-247.00
  • 97.47%
  • TargetMol Chemicals Inc.

GSK3359088 Spectrum

GSK3359088(1628830-21-6)1HNMR

1628830-21-6 (GSK3359088) Related Search:

GSK3359088 PF-06726304 Urolithin B 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-5-ethyl-6-[ethyl(tetrahydropyran-4-yl)amino]-2-(1-piperidylmethyl)benzofuran-4-carboxamide
TC LPA5 4

1of2

GSK3359088 EZM2302 (GSK3359088) EZM2302;EZM-2302;EZM 2302 CS-2741 2,7-Diazaspiro[3.5]nonane-7-carboxylic acid, 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-4-pyrimidinyl]-, methyl ester Methyl 2-(2-(2-chloro-5-((R)-2-hydroxy-3-(methylamino)propoxy)phenyl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate Methyl 2-[2-[2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl]-6-(3,5-dimethyl-4-isoxazolyl)-5-methyl-4-pyrimidinyl]-2,7-diazaspiro[3.5]nonane-7-carboxylate inhibit,Inhibitor,EZM2302,Histone Methyltransferase,EZM 2302,EZM-2302 methyl 2-(2-{2-chloro-5-[(2R)-2-hydroxy-3-(methylamino)propoxy]phenyl}-6-(3,5-dimethyl-1,2-oxazol-4-yl)-5-methylpyrimidin-4-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate EZM 2302, 10 mM in DMSO EZM2302 1628830-21-6 C29H37ClN6O5