4-Cyanobenzene-1-sulfonamide
- CAS No.
- 3119-02-6
- Chemical Name:
- 4-Cyanobenzene-1-sulfonamide
- Synonyms
- 4-Cyanobenzenesulphonamide;BUTTPARK 48\11-02;4-CYANOBENZENE-1-S;4-CYANOBENZENE-1-SUL;4-Sulphamoylbenzonitrile;4-CYANOBENZENESULFONAMIDE;p-cyano-benzenesulfonamid;p-cyanobenzenesulphonamide;Benzenesulfonamide, 4-cyano-;4-Cyanobenzene-1-sulfonamide
- CBNumber:
- CB9367133
- Molecular Formula:
- C7H6N2O2S
- Molecular Weight:
- 182.2
- MDL Number:
- MFCD00178767
- MOL File:
- 3119-02-6.mol
- MSDS File:
- SDS
| Melting point | 166 °C |
|---|---|
| Boiling point | 400.7±47.0 °C(Predicted) |
| Density | 1.3827 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| RTECS | DB1582000 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 9.57±0.10(Predicted) |
| form | solid |
| color | Off-white |
| Water Solubility | 1.111g/L(15 ºC) |
| InChI | 1S/C7H6N2O2S/c8-5-6-1-3-7(4-2-6)12(9,10)11/h1-4H,(H2,9,10,11) |
| InChIKey | UZECCNDOASGYNH-UHFFFAOYSA-N |
| SMILES | NS(=O)(=O)c1ccc(cc1)C#N |
| CAS DataBase Reference | 3119-02-6(CAS DataBase Reference) |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P280h-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39-36/37 | |||||||||
| RIDADR | 3276 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| Hazard Note | Harmful | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29350090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
4-Cyanobenzene-1-sulfonamide price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR23947 | 4-Cyanobenzenesulphonamide 95 | 3119-02-6 | 1g | $28 | 2026-06-04 | Buy |
| Apolloscientific | OR23947 | 4-Cyanobenzenesulphonamide 95 | 3119-02-6 | 5g | $82 | 2026-06-04 | Buy |
| Matrix Scientific | 021392 | 4-Cyanobenzenesulfonamide | 3119-02-6 | 5.00g | $64 | 2026-05-18 | Buy |
| Matrix Scientific | 021392 | 4-Cyanobenzenesulfonamide | 3119-02-6 | 10.00g | $97 | 2026-05-18 | Buy |
| Matrix Scientific | 021392 | 4-Cyanobenzenesulfonamide | 3119-02-6 | 25.00g | $208 | 2026-05-18 | Buy |
4-Cyanobenzene-1-sulfonamide Chemical Properties, Uses, Production
Uses
4-Cyanobenzene-1-sulfonamide is a carbonic anhydrase inhibitor.
Synthesis
49584-26-1
3119-02-6
General procedure for the synthesis of p-cyanobenzenesulfonamide from 4-cyanobenzenesulfonyl chloride: 4-cyanobenzenesulfonyl chloride (10 mmol) was dissolved in anhydrous tetrahydrofuran (40 mL). A 30% aqueous ammonium hydroxide solution (3 mL) was slowly added to the reaction mixture at 0 °C, followed by stirring the reaction for 1 h at room temperature. After completion of the reaction, the reaction mixture was extracted with ethyl acetate and the organic phase was dried with anhydrous sodium sulfate. After concentration under reduced pressure, the white solid product p-cyanobenzenesulfonamide (1.6 g, 88% yield) was obtained by grinding with ether. The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6) and 13C NMR (100 MHz, DMSO-d6): 1H NMR δ 8.11 (2H, d, J = 8.58 Hz), 8.02 (2H, d, J = 8.62 Hz), 7.69 (2H, bs, NH2, exchange with D2O); 13C NMR δ 148.9, 134.2, 127.4, 118.8, 115.3.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1214 - 1222
[2] Zhurnal Obshchei Khimii, 1948, vol. 18, p. 110,112
[3] Chem.Abstr., 1948, p. 4976
[4] American Chemical Journal, 1896, vol. 18, p. 163,165
[5] Bioorganic and Medicinal Chemistry, 2017, vol. 25, # 16, p. 4397 - 4406
4-Cyanobenzene-1-sulfonamide Preparation Products And Raw materials
Raw materials
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Preparation Products
4-Cyanobenzene-1-sulfonamide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai Yolne Chemical Co., Ltd. | 021-62960152 | 934678158@qq.com | China | 9886 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
View Latest Price from 4-Cyanobenzene-1-sulfonamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-08-11 | 4-CYANOBENZENE-1-SULFONAMIDE
3119-02-6
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd |
-
- 4-CYANOBENZENE-1-SULFONAMIDE
3119-02-6
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
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