5-Hydroxypyrimidine
- CAS No.
- 26456-59-7
- Chemical Name:
- 5-Hydroxypyrimidine
- Synonyms
- pyrimidin-5-ol;5-Pyrimidinol;5-Hydroxypyrimidine;5-Hydroxypyrimidine ,98%;5-Hydroxypyrimidine acetate;5-HydroxypyriMidine. AcOH salt;5-Pyrimidinol (6CI,7CI,8CI,9CI);Pyrimidin-5-ol, 5-Hydroxy-1,3-diazine;5-Hydroxypyrimidine 97% (acetate salt);5-Hydroxypyrimidine ISO 9001：2015 REACH
- CBNumber:
- CB9501580
- Molecular Formula:
- C4H4N2O
- Molecular Weight:
- 96.09
- MDL Number:
- MFCD06412562
- MOL File:
- 26456-59-7.mol
- MSDS File:
- SDS
| Melting point | 212-214°C |
|---|---|
| Boiling point | 227.2±13.0 °C(Predicted) |
| Density | 1.293±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 6.60±0.10(Predicted) |
| color | Light Beige to Beige |
| InChI | InChI=1S/C4H4N2O/c7-4-1-5-3-6-2-4/h1-3,7H |
| InChIKey | LTXJLQINBYSQFU-UHFFFAOYSA-N |
| SMILES | C1=NC=C(O)C=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271 |
| HS Code | 29335990 |
5-Hydroxypyrimidine price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | H9111-57 | 5-Hydroxypyrimidine (5-Pyrimidinol) | 26456-59-7 | 100mg | $319 | 2026-06-03 | Buy |
| Biosynth | FH24495 | 5-Hydroxypyrimidine | 26456-59-7 | 2g | $900 | 2026-06-04 | Buy |
| Biosynth | FH24495 | 5-Hydroxypyrimidine | 26456-59-7 | 1g | $900 | 2026-06-04 | Buy |
| Biosynth | FH24495 | 5-Hydroxypyrimidine | 26456-59-7 | 0.5g | $900 | 2026-06-04 | Buy |
| Biosynth | FH24495 | 5-Hydroxypyrimidine | 26456-59-7 | 0.25g | $900 | 2026-06-04 | Buy |
5-Hydroxypyrimidine Chemical Properties,Uses,Production
Chemical Properties
Tan Solid
Uses
5-Hydroxypyrimidine (cas# 26456-59-7) is a compound useful in organic synthesis.
Synthesis
31458-33-0
26456-59-7
General procedure for the synthesis of 5-hydroxypyrimidine from 5-methoxypyrimidine: a mixture of 5-methoxypyrimidine (2.99 g, 27.2 mmol) and powdered potassium hydroxide (8.96 g, 85%, 136 mmol) in methanol (50 mL) was placed in a sealed tube and the reaction was heated at 150 °C overnight. Upon completion of the reaction, the mixture was cooled to room temperature, neutralized by the addition of acetic acid and subsequently concentrated under reduced pressure. The resulting residue was ground with hot acetonitrile (2 x 100 mL), the acetonitrile extracts were combined and concentrated under reduced pressure to give 7.51 g of an off-white solid. The solid was ground with hot ethyl acetate (100 mL) and the ethyl acetate extract was concentrated under reduced pressure to give 1.81 g of off-white solid. Finally, further purification by fast chromatography (silica gel as stationary phase and 9:1 dichloromethane/methanol as mobile phase) afforded the target product 5-hydroxypyrimidine (1.11 g, 43% yield) as an off-white solid. Its 1H NMR (300 MHz, DMSO-d6) data were as follows: δ 10.45 (broad single peak, 1H), 8.67 (single peak, 1H), 8.34 (single peak, 2H).
References
[1] Chemistry - A European Journal, 2003, vol. 9, # 20, p. 4997 - 5010
[2] Patent: US2006/173049, 2006, A1. Location in patent: Page/Page column 28-29
[3] Patent: WO2008/65393, 2008, A1. Location in patent: Page/Page column 30
[4] Chemistry and Industry (London, United Kingdom), 1956, p. 1453
[5] Patent: US2002/143025, 2002, A1
5-Hydroxypyrimidine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing EnMing Pharmaceutical Technology Co., Ltd. | 13305188663 | njempt@163.com | China | 16 | 58 |
| Nanbu County Chengxin Technology Co., Ltd. | 0838-5675166 15883665058 | nbcxkj@126.com | China | 956 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| EnciPharmatech Co., Ltd | 025-52714267-66 13813902930 | stephen_shengll@hotmail.com | China | 231 | 64 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
View Lastest Price from 5-Hydroxypyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 5-Hydroxypyrimidine
26456-59-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2021-07-13 | 5-Hydroxypyrimidine
26456-59-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 5-Hydroxypyrimidine
26456-59-7
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 5-Hydroxypyrimidine
26456-59-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 5-Hydroxypyrimidine
26456-59-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 5-Hydroxypyrimidine
26456-59-7
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
