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2-Chloro-5-hydroxypyrimidine

2-Chloro-5-hydroxypyrimidine Structure
2-Chloro-5-hydroxypyrimidine structure
CAS No.
4983-28-2
Chemical Name:
2-Chloro-5-hydroxypyrimidine
Synonyms
2-Chloropyrimidin-5-ol;Piribedil Impurity 17;2-Chloro-5-pyrimidinol;5-PyriMidinol,2-chloro-;2-Chloro-5-hydroxypyrimid...;2-Chloro-5-hydroxypyrimidine;2-Chloro-5-hydroxypyrimidine 98%;5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI);2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH;TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2
CBNumber:
CB0947875
Molecular Formula:
C4H3ClN2O
Molecular Weight:
130.53
MDL Number:
MFCD09743796
MOL File:
4983-28-2.mol
MSDS File:
SDS
Last updated:2026-08-05 14:47:54
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2-Chloro-5-hydroxypyrimidine Properties

Melting point 195-196 °C
Boiling point 328.1±15.0 °C(Predicted)
Density 1.513±0.06 g/cm3(Predicted)
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 6.17±0.23(Predicted)
Appearance Off-white to light brown Solid
InChI InChI=1S/C4H3ClN2O/c5-4-6-1-3(8)2-7-4/h1-2,8H
InChIKey BOGPIHXNWPTGNH-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C(O)C=N1
CAS DataBase Reference 4983-28-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P271-P280
HS Code  29335990
REACH Registrations Active

2-Chloro-5-hydroxypyrimidine price More Price(80)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical C3685 2-Chloro-5-hydroxypyrimidine min. 98.0 % 4983-28-2 1G $33 2026-04-30 Buy
TCI Chemical C3685 2-Chloro-5-hydroxypyrimidine min. 98.0 % 4983-28-2 5G $128 2026-04-30 Buy
Usbiological 416917 2-Chloro-5-hydroxypyrimidine 4983-28-2 1g $340 2026-06-03 Buy
Usbiological 416917 2-Chloro-5-hydroxypyrimidine 4983-28-2 2.5g $446 2026-06-03 Buy
Apolloscientific OR40574 2-Chloro-5-hydroxypyrimidine 98% 4983-28-2 250mg $21 2026-06-04 Buy
Product number Packaging Price Buy
C3685 1G $33 Buy
C3685 5G $128 Buy
416917 1g $340 Buy
416917 2.5g $446 Buy
OR40574 250mg $21 Buy

2-Chloro-5-hydroxypyrimidine Chemical Properties, Uses, Production

Uses

2-Chloro-5-hydroxypyrimidine is an intermediate used to synthesize tandospirone derivatives with anxiolytic activities.

Hazard

2-Chloro-5-hydroxypyrimidine is an irritant. Contact may cause skin irritation, severe eye irritation and respiratory tract irritation.

Synthesis

2-Chloro-5-methoxypyrimidine (0.46 g, 3.18 mmol) in methylene chloride (10 mL) was treated with 1.0 N boron tribromide (16 mL, 16 mmol) at room temperature. The solution was stirred overnight. After that, the reaction was partitioned between saturated NaHCO3 and DCM. The aqueous layer was extracted with additional DCM. Combined the organic layers and dried (MgSO4), filtered, and concentrated to obtain the crude product. The residue was purified by flash column chromatography on silica gel to give 2-Chloro-5-hydroxypyrimidine.2-Chloro-5-hydroxypyrimidine

References

[1] Patent: WO2010/80503, 2010, A1. Location in patent: Page/Page column 225
[2] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 27
[3] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24-25
[4] Patent: WO2016/164703, 2016, A1. Location in patent: Page/Page column 50
[5] Patent: US5589478, 1996, A

2-Chloro-5-hydroxypyrimidine synthesis

22536-65-8
4983-28-2
Synthesis of 2-Chloro-5-hydroxypyrimidine from 2-Chloro-5-methoxypyrimidine

2-Chloro-5-hydroxypyrimidine Preparation Products And Raw materials

Raw materials

2-Chloro-5-methoxypyrimidine Dichloromethane 5-Amino-2-chloropyrimidine Boron tribromide

Preparation Products

2-Chloro-5-hydroxypyrimidine Suppliers

Global Suppliers ( 303)
Supplier Tel Email Country ProdList Advantage
Shandong Shining Pharm Co.,Ltd 18866891188 18866891188 zhaojiangxia@shiningpharm.com China 203 58
PharmaBlock Sciences (Nanjing), Inc. 4000255188 marketing@pharmablock.com China 9126 58
Haimen Ruiyi Medical Tech Co., LTD 021-54718086 sales5@ruiyitech.com China 271 58
Hangzhou Copiore Chemical Co., Ltd. 17300981287 13757145729 sales@copiore.com China 291 58
Beijing Huize Zhongsen Pharmaceutical Technology Co., Ltd. 18519331287 18519331287 1751713684@qq.com China 268 58
Nanjing Intermate Technology Co., Ltd 18501091076 57715449@qq.com China 102 58
Shandong Xuanshuo Pharmaceutical Technology Co. LTD 15269103900 suchangzhou@shiningpharm.com China 383 58
Nanbu County Chengxin Technology Co., Ltd. 0838-5675166 15883665058 nbcxkj@126.com China 956 55
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Supplier Advantage
Shandong Shining Pharm Co.,Ltd 58
PharmaBlock Sciences (Nanjing), Inc. 58
Haimen Ruiyi Medical Tech Co., LTD 58
Hangzhou Copiore Chemical Co., Ltd. 58
Beijing Huize Zhongsen Pharmaceutical Technology Co., Ltd. 58
Nanjing Intermate Technology Co., Ltd 58
Shandong Xuanshuo Pharmaceutical Technology Co. LTD 58
Nanbu County Chengxin Technology Co., Ltd. 55
J & K SCIENTIFIC LTD. 76
Energy Chemical 61

View Latest Price from 2-Chloro-5-hydroxypyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-hydroxypyrimidine pictures 2026-08-20 2-Chloro-5-hydroxypyrimidine
4983-28-2
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-Chloro-5-hydroxypyrimidine pictures 2026-06-30 2-Chloro-5-hydroxypyrimidine
4983-28-2
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Chloro-5-hydroxypyrimidine? pictures 2026-06-08 2-Chloro-5-hydroxypyrimidine?
4983-28-2
 1kg 99% 1 Jinan Ruitong Biotech Co., Ltd.

2-Chloro-5-hydroxypyrimidine Spectrum

2-Chloro-5-hydroxypyrimidine(4983-28-2)1HNMR

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2-Chloro-5-hydroxypyrimidine 98% 2-Chloro-5-hydroxypyrimidine 5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI) 2-Chloro-5-hydroxypyrimid... 5-PyriMidinol,2-chloro- 2-Chloropyrimidin-5-ol, 2-Chloro-5-hydroxy-1,3-diazine 2-Chloro-5-pyrimidinol 2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH Piribedil Impurity 17 TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2 2-Chloropyrimidin-5-ol 4983-28-2 1983-28-2 Heterocycle-Pyrimidine series PYRIMIDINE pharmacetical Pyrimidines