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2-Chloro-5-hydroxypyrimidine

2-Chloro-5-hydroxypyrimidine structure

CAS No.: 4983-28-2

Chemical Name:: 2-Chloro-5-hydroxypyrimidine

Synonyms: 2-Chloropyrimidin-5-ol;Piribedil Impurity 17;2-Chloro-5-pyrimidinol;5-PyriMidinol,2-chloro-;2-Chloro-5-hydroxypyrimid...;2-Chloro-5-hydroxypyrimidine;2-Chloro-5-hydroxypyrimidine 98%;5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI);2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH;TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2

CBNumber:: CB0947875

Molecular Formula:: C4H3ClN2O

Molecular Weight:: 130.53

MDL Number:: MFCD09743796

MOL File:: 4983-28-2.mol

MSDS File:: SDS

Last updated:2025-08-28 09:12:15

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2-Chloro-5-hydroxypyrimidine Properties

Melting point	195-196 °C
Boiling point	328.1±15.0 °C(Predicted)
Density	1.513±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	6.17±0.23(Predicted)
Appearance	Off-white to light brown Solid
InChI	InChI=1S/C4H3ClN2O/c5-4-6-1-3(8)2-7-4/h1-2,8H
InChIKey	BOGPIHXNWPTGNH-UHFFFAOYSA-N
SMILES	C1(Cl)=NC=C(O)C=N1
CAS DataBase Reference	4983-28-2(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P271-P280
HS Code	29335990

2-Chloro-5-hydroxypyrimidine price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	C3685	2-Chloro-5-hydroxypyrimidine min. 98.0 %	4983-28-2	1G	$32	2025-07-31	Buy
TCI Chemical	C3685	2-Chloro-5-hydroxypyrimidine min. 98.0 %	4983-28-2	5G	$126	2025-07-31	Buy
TRC	C373980	2-Chloro-5-hydroxypyrimidine	4983-28-2	1g	$70	2021-12-16	Buy
TRC	C373980	2-Chloro-5-hydroxypyrimidine	4983-28-2	10g	$275	2021-12-16	Buy
TRC	C373980	2-Chloro-5-hydroxypyrimidine	4983-28-2	25g	$495	2021-12-16	Buy

Product number	Packaging	Price	Buy
C3685	1G	$32	Buy
C3685	5G	$126	Buy
C373980	1g	$70	Buy
C373980	10g	$275	Buy
C373980	25g	$495	Buy

2-Chloro-5-hydroxypyrimidine Chemical Properties,Uses,Production

Uses

2-Chloro-5-hydroxypyrimidine is an intermediate used to synthesize tandospirone derivatives with anxiolytic activities.

Synthesis

2-Chloro-5-methoxypyrimidine (0.46 g, 3.18 mmol) in methylene chloride (10 mL) was treated with 1.0 N boron tribromide (16 mL, 16 mmol) at room temperature. The solution was stirred overnight. After that, the reaction was partitioned between saturated NaHCO3 and DCM. The aqueous layer was extracted with additional DCM. Combined the organic layers and dried (MgSO4), filtered, and concentrated to obtain the crude product. The residue was purified by flash column chromatography on silica gel to give 2-Chloro-5-hydroxypyrimidine.

References

[1] Patent: WO2010/80503, 2010, A1. Location in patent: Page/Page column 225
[2] Patent: WO2011/144578, 2011, A1. Location in patent: Page/Page column 27
[3] Patent: WO2011/144577, 2011, A1. Location in patent: Page/Page column 24-25
[4] Patent: WO2016/164703, 2016, A1. Location in patent: Page/Page column 50
[5] Patent: US5589478, 1996, A

2-Chloro-5-hydroxypyrimidine synthesis

Synthesis of 2-Chloro-5-hydroxypyrimidine from 2-Chloro-5-methoxypyrimidine

2-Chloro-5-hydroxypyrimidine Preparation Products And Raw materials

Raw materials

2-Chloro-5-methoxypyrimidine Dichloromethane 5-Amino-2-chloropyrimidine Boron tribromide

Preparation Products

2-Chloro-5-hydroxypyrimidine Suppliers

Global( 284)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Boc Chemical Co., Ltd.	021-34975602; +8618721111801	shangli@bocchem.com	China	138	58
Hebei Mujin Biotechnology Co.,Ltd	+8613288715578	sales@hbmojin.com	China	12398	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3009	60
Fluoropharm Co., Ltd.	+86-0571-85586753 +86-13336034509	sales@fluoropharm.com	China	1445	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58

Supplier	Advantage
Shanghai Boc Chemical Co., Ltd.	58
Hebei Mujin Biotechnology Co.,Ltd	58
Frapp's ChemicalNFTZ Co., Ltd.	50
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Nanjing ChemLin Chemical Industry Co., Ltd.	60
Fluoropharm Co., Ltd.	60
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58

View Lastest Price from 2-Chloro-5-hydroxypyrimidine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-29	2-Chloro-5-hydroxypyrimidine? 4983-28-2	US $0.00-0.00 / kg	1kg	99%	1	Jinan Ruitong Biotech Co., Ltd.
2025-08-21	2-Chloro-5-hydroxypyrimidine 4983-28-2	US $0.00 / Kg/Drum	1Kg/Drum	99%	5000KG	Hebei Mujin Biotechnology Co.,Ltd
2025-07-25	2-Chloro-5-hydroxypyrimidine 4983-28-2	US $0.00-0.00 / KG	1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

2-Chloro-5-hydroxypyrimidine?
4983-28-2
US $0.00-0.00 / kg
99%
Jinan Ruitong Biotech Co., Ltd.

2-Chloro-5-hydroxypyrimidine
4983-28-2
US $0.00 / Kg/Drum
99%
Hebei Mujin Biotechnology Co.,Ltd

2-Chloro-5-hydroxypyrimidine
4983-28-2
US $0.00-0.00 / KG
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-Chloro-5-hydroxypyrimidine Spectrum

2-Chloro-5-hydroxypyrimidine(4983-28-2)¹HNMR

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2-Chloro-5-hydroxypyrimidine 98% 2-Chloro-5-hydroxypyrimidine 5-Pyrimidinol, 2-chloro- (7CI,8CI,9CI) 2-Chloropyrimidin-5-ol 2-Chloro-5-hydroxypyrimid... 5-PyriMidinol,2-chloro- 2-Chloropyrimidin-5-ol, 2-Chloro-5-hydroxy-1,3-diazine 2-Chloro-5-pyrimidinol 2-Chloro-5-hydroxypyrimidine ISO 9001：2015 REACH Piribedil Impurity 17 TIANFU-CHEM 2-Chloro-5-hydroxypyrimidine 4983-28-2 4983-28-2 1983-28-2 Heterocycle-Pyrimidine series PYRIMIDINE pharmacetical Pyrimidines