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2,2',4'-Trichloroacetophenone

2,2',4'-Trichloroacetophenone structure

CAS No.: 4252-78-2

Chemical Name:: 2,2',4'-Trichloroacetophenone

Synonyms: 2-CHLORO-1-(2,4-DICHLOROPHENYL)ETHANONE;TRICHLOROACETOPHENONE;2,2′,4′-Trichloracetophenon;2,2,4-TRICHLORO ACETOPHENONE;Ethanone, 2-chloro-1-(2,4-dichlorophenyl)-;alpha-2,4-Tric;2,2',4'-TrichL;2,2',4-Trichloro;TRICHLOROACETOPHENON;Econazole Impurity 11

CBNumber:: CB9689842

Molecular Formula:: C8H5Cl3O

Molecular Weight:: 223.48

MDL Number:: MFCD00000934

MOL File:: 4252-78-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-04 16:00:12

Product description	Number	Pack Size	Price
2,2′,4′-Trichloroacetophenone 97%	159255	25g	$65.7
2,2',4'-Trichloroacetophenone >98.0%(GC)	T1405	25g	$41
2,2',4'-Trichloroacetophenone >98.0%(GC)	T1405	250g	$228
2,4-Dichloro-a-chloroacetophenone 99+% (GC) ≥99%(GC)	230893	100g	$213
2,4-Dichloro-a-chloroacetophenone 99+% (GC) ≥99%(GC)	230893	250g	$425
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2,2',4'-Trichloroacetophenone Properties

Melting point	47-54 °C(lit.)
Boiling point	130-135 °C4 mm Hg(lit.)
Density	1,312 g/cm³
refractive index	1.5510 (estimate)
Flash point	>230 °F
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	60 mg/L (20°C)
form	Solid
color	beige to yellow
PH	4.96 at 25.1℃ and 10g/L
Water Solubility	60 mg/L (20 ºC)
Sensitive	Lachrymatory
BRN	957098
InChI	1S/C8H5Cl3O/c9-4-8(12)6-2-1-5(10)3-7(6)11/h1-3H,4H2
InChIKey	VYWPPRLJNVHPEU-UHFFFAOYSA-N
SMILES	ClCC(=O)c1ccc(Cl)cc1Cl
CAS DataBase Reference	4252-78-2(CAS DataBase Reference)
FDA UNII	2E35P7HJI2
EPA Substance Registry System	Ethanone, 2-chloro-1-(2,4-dichlorophenyl)- (4252-78-2)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H315-H317-H318-H335

Precautionary statements

P261-P280-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Xi,C,N,T

Risk Statements

37/38-41-43-51/53-34-23/24/25

Safety Statements

26-36/37/39-61-45-37/39

RIDADR

1759

WGK Germany

Hazard Note

Corrosive/Lachrymatory

HazardClass

PackingGroup

III

HS Code

29147090

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Dam. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3

REACH Registrations

Active

Limited Quantities

5.0 kg (11 lbs) (solid)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

NFPA 704

	1
3		0

2,2',4'-Trichloroacetophenone price More Price(56)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	159255	2,2′,4′-Trichloroacetophenone 97%	4252-78-2	25g	$65.7	2026-04-30	Buy
TCI Chemical	T1405	2,2',4'-Trichloroacetophenone >98.0%(GC)	4252-78-2	25g	$41	2026-04-30	Buy
TCI Chemical	T1405	2,2',4'-Trichloroacetophenone >98.0%(GC)	4252-78-2	250g	$228	2026-04-30	Buy
Usbiological	230893	2,4-Dichloro-a-chloroacetophenone 99+% (GC) ≥99%(GC)	4252-78-2	100g	$213	2026-06-03	Buy
Usbiological	230893	2,4-Dichloro-a-chloroacetophenone 99+% (GC) ≥99%(GC)	4252-78-2	250g	$425	2026-06-03	Buy

Product number	Packaging	Price	Buy
159255	25g	$65.7	Buy
T1405	25g	$41	Buy
T1405	250g	$228	Buy
230893	100g	$213	Buy
230893	250g	$425	Buy

2,2',4'-Trichloroacetophenone Chemical Properties,Uses,Production

Chemical Properties

yellow crystalline powde

Uses

α,2,4-Trichloroacetophenone is a reagent used in the synthesis of isoconazole, a potent antifungal agent.

General Description

Off-white crystalline solid.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

2,2',4'-Trichloroacetophenone is incompatible with strong oxidizers and strong bases. .

Fire Hazard

2,2',4'-Trichloroacetophenone is probably combustible.

Synthesis

79-04-9

541-73-1

4252-78-2

To a three-necked flask equipped with a stirrer was added 1,3-dichlorobenzene (147 g), chloroacetyl chloride (113 g) and methylene chloride (750 mL) at room temperature. Under stirring, anhydrous aluminum trichloride (147 g) was added in batches. After the addition was complete, the reaction mixture was heated to reflux and maintained for 3 hours to ensure complete reaction. Upon completion of the reaction, the mixture was quenched by carefully pouring it into ice water. Subsequently, the organic and aqueous phases were separated. The organic phase was washed sequentially with deionized water (500 mL x 2) and saturated sodium bicarbonate solution (500 mL x 2) to remove acidic impurities. The washed organic phase was dried with anhydrous sodium sulfate and filtered to remove the desiccant. The filtrate was concentrated by rotary evaporation and petroleum ether (1200 mL) was added to the residue. The mixture was cooled to room temperature and placed in a refrigerator overnight to promote crystallization. The following day, the crystallized product was collected by filtration and washed with a small amount of cold petroleum ether. Ultimately, the product was dried under vacuum to give 2,2',4'-trichloroacetophenone (193 g, 86% yield) in the form of an off-white solid.

References

[1] Journal of Chemical Sciences, 2015, vol. 127, # 12, p. 2251 - 2260
[2] Patent: CN105566309, 2016, A. Location in patent: Paragraph 0003; 0007
[3] Chemische Berichte, 1907, vol. 40, p. 1703
[4] Tetrahedron Asymmetry, 2003, vol. 14, # 24, p. 3861 - 3866
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 20, p. 5368 - 5371

2,2',4'-Trichloroacetophenone synthesis

Synthesis of 2,2',4'-Trichloroacetophenone from Chloroacetyl chloride and 1,3-Dichlorobenzene

2,2',4'-Trichloroacetophenone Preparation Products And Raw materials

Raw materials

Chloroacetyl chloride 2,2,2',4'-TETRACHLOROACETOPHENONE 2,4-DICHLORO-ALPHA-METHYLBENZYL ALCOHOL 2',4'-Dichloroacetophenone 1,3-Dichlorobenzene

Dichloromethane Aluminum chloride 1,2-Dichlorobenzene Chloroacetamide

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Preparation Products

ALPHA-(CHLOROMETHYL)-2,4-DICHLOROBENZYL ALCOHOL Oxiconazole nitrate Isoconazole (Z)-2'-(1H-Imidazole-1-yl)-2,4-dichloroacetophenone oxime

2,2',4'-Trichloroacetophenone Suppliers

Global( 451)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Neostar United (Changzhou) Industrial Co., Ltd.	+86-0519-85551759 +8613506123987	marketing1@neostarunited.com	China	8828	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-86-13131129325 +8613131129325	sales1@chuanghaibio.com	China	5220	58
Shanghai Qyubiotech Co., Ltd.	+86-086-021-37596619 +8618019359838	info@qyubiotech.com	China	307	58
Hebei Zhuanglai Chemical Trading Co Ltd	+86-16264648883	niki@zlchemi.com	China	7245	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
NINGBO INNO PHARMCHEM CO., LTD.	13867897135	sales@nbinno.com	CHINA	923	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10403	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2165	58

Supplier	Advantage
Neostar United (Changzhou) Industrial Co., Ltd.	58
Hebei Chuanghai Biotechnology Co,.LTD	58
Shanghai Qyubiotech Co., Ltd.	58
Hebei Zhuanglai Chemical Trading Co Ltd	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
NINGBO INNO PHARMCHEM CO., LTD.	58
Shenzhen Nexconn Pharmatechs Ltd	58
Changzhou Ditong Chemical Co.,Ltd	58

View Lastest Price from 2,2',4'-Trichloroacetophenone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-05-28	2, 2′, 4′-Trichloroacetophenone 4252-78-2	$8.70	10kg	99%	10000kg	Hebei Chuanghai Biotechnology Co,.LTD
2025-06-04	2,2',4'-Trichloroacetophenone 4252-78-2		1kg	99%+	100000kgs per month	Shanghai Qyubiotech Co., Ltd.
2025-05-23	2,2',4'-Trichloroacetophenone 4252-78-2	$50.00	1kg	99	5000	Hebei Zhuanglai Chemical Trading Co Ltd

2, 2′, 4′-Trichloroacetophenone
4252-78-2
$8.70
99%
Hebei Chuanghai Biotechnology Co,.LTD

2,2',4'-Trichloroacetophenone
4252-78-2
99%+
Shanghai Qyubiotech Co., Ltd.

2,2',4'-Trichloroacetophenone
4252-78-2
$50.00
99
Hebei Zhuanglai Chemical Trading Co Ltd

2,2',4'-Trichloroacetophenone Spectrum

2,2',4'-Trichloroacetophenone(4252-78-2)MS 2,2',4'-Trichloroacetophenone(4252-78-2)¹HNMR 2,2',4'-Trichloroacetophenone(4252-78-2)¹³CNMR 2,2',4'-Trichloroacetophenone(4252-78-2)IR1 2,2',4'-Trichloroacetophenone(4252-78-2)IR2

4252-78-2(2,2',4'-Trichloroacetophenone)Related Search:

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à,2,4-trichloroacetophenone alpha-2,4-trichloroacetophenon ω,2,4-trichloroacetophenone 2,2′,4′-Trichloracetophenon 2-2,4-TRICHLORO ACETOPHENONE 99+% 2-chloro-2’,4’-dichloroacetophenone,2,2',4'-trichloroacetophenone 2,2'',4''-TRICHLOROACETOPHENONEECONAZOLE 2,2',4'-TRICHLOROACETOPHENONE, TECH., 90% 2-Chloro-24Dichloroacetophenone 2',4'-Dichloro-α-chloroacetophenone (Trichloroacetyl)benzene 2,2',4'-Trichloroacetophenone,95% 2,2',4'-Trichloroacetophenone,90%,tech. ω,2,4-Trichloroacetophenone, 2,4-Dichlorophenacyl chloride 2,2′,4′-Trichloroacetophenone,ω,2,4-Trichloroacetophenone, 2,4-Dichlorophenacyl chloride 2,2',4'-Trichloroacetophenone, 2-Chloro-1-(2,4-dichlorophenyl)ethan-1-one 2,2 ', 4'-trichloro acetophenone 2,2,4-trichloro acetophenone 2, 4-trichlorobenzene trichlorobenzene ethyl ketone alpha-2,4-Tric 2,2',4'-TRICHLORO PHENYL ETH LABOTEST-BB LT00233191 2,2',4-TRICHLOROACETOPHENENONE 2,2',4-TRICHLORO ACETOPHENONE 2',2,4-TRICHLOROACETOPHENONE 2,2',4'-TRICHLORO PHENYL ETHANONE 2,4-DICHLOROPHENACYL CHLORIDE A,2,4-TRICHLOROACETOPHENONE ALPHA-CHLORO-2,4-DICHLOROACETOPHENONE ALPHA,2,4-TRICHLOROACETOPHENONE alpha,2,4-Trichloroacetophenone~2,2,4-Trichloroacetophenone chloromethyl 2,4-dichlorophenyl ketone TRICHLOROACETOPHENON 2,2',4'-Trichloroacetophenone 2-Chloro-1-(2,4-Dichlorophenyl)ethanone 2,4,W-Trichloroacetophenon 2,2',4-Trichloro Ethanone, 2-chloro-1-(2,4-dichlorophenyl)- 2,4-dichlorphenacylchloride OMEGA,2,4-TRICHLOROACETOPHENONE Econazole Impurity 11 2,2',4'-TrichL α,2,4-Trichloroacetophenone 2,2',4'- Trichloroacetopheone 2,2,4-Dichloro phenacyl Chloride / 2,2,4- trichloro acetophenone 2,2',4'-Trichloroacetophenone 2,2′,4′-Trichloroacetophenone, CAS 4252-78-2 -Trichloroacetophenone 2,2',4'-Trichloroacetophenone (Econazole Impurity) 2,2,4-TRICHLORO ACETOPHENONE 2-CHLORO-1-(2,4-DICHLOROPHENYL)ETHANONE TRICHLOROACETOPHENONE 4252-78-2 4252-78-0 Cl2C6H3COCH2Cl C8H5CI3O Building Blocks C7 to C8 Carbonyl Compounds Ketones