4-Fluoro-1,3-dihydro-2H-indol-2-one
- CAS No.
- 138343-94-9
- Chemical Name:
- 4-Fluoro-1,3-dihydro-2H-indol-2-one
- Synonyms
- 4-fluoro-1H-indol-2-ol;4-Fluorooxindole;4-FLUOROINDOLIN-2-ONE;4-fluoroindoline-2-one;4-Fluoro-2-oxindole97%;4-Fluoro-2H-indol-2-one;1H-indol-4-yl hypofluorite;4-Fluoro-1,3-dihydro-indol-2-one;4-Fluoro-2,3-dihydro-1H-indol-2-one;4-FLUORO-1,3-DIHYDRO-2H-INDOL-2-ONE
- CBNumber:
- CB9711657
- Molecular Formula:
- C8H6FNO
- Molecular Weight:
- 151.14
- MDL Number:
- MFCD04112528
- MOL File:
- 138343-94-9.mol
- MSDS File:
- SDS
| Boiling point | 297.2±40.0 °C(Predicted) |
|---|---|
| Density | 1.311±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 13.08±0.20(Predicted) |
| form | powder |
| color | Faint creamy orange |
| InChI | InChI=1S/C8H6FNO/c9-6-2-1-3-7-5(6)4-8(11)10-7/h1-3H,4H2,(H,10,11) |
| InChIKey | WKDSLMNPSVQOES-UHFFFAOYSA-N |
| SMILES | N1C2=C(C(F)=CC=C2)CC1=O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P280-P305+P351+P338 |
| Hazard Codes | Xi |
| HS Code | 2933790090 |
4-Fluoro-1,3-dihydro-2H-indol-2-one price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC8677 | 4-Fluoro-2-oxindole 97% | 138343-94-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC8677 | 4-Fluoro-2-oxindole 97% | 138343-94-9 | 5g | $41 | 2026-06-04 | Buy |
| Apolloscientific | PC8677 | 4-Fluoro-2-oxindole 97% | 138343-94-9 | 10g | $74 | 2026-06-04 | Buy |
| Synthonix | F48095 | 4-Fluoroindolin-2-one 97% | 138343-94-9 | 100mg | $22 | 2026-05-06 | Buy |
| Synthonix | F48095 | 4-Fluoroindolin-2-one 97% | 138343-94-9 | 250mg | $26 | 2026-05-06 | Buy |
4-Fluoro-1,3-dihydro-2H-indol-2-one Chemical Properties, Uses, Production
Synthesis
136916-19-3
138343-94-9
General procedure for the synthesis of 4-fluoroindol-2-one from 2-fluoro-6-nitrophenylacetic acid: (2-fluoro-6-nitrophenyl)acetic acid (3.3 g, 16.6 mmol) was dissolved in acetic acid (20 mL) and the hydrogenation reaction was carried out for 24 hours using a 10% palladium-carbon catalyst (0.5 g) under 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was filtered through Celite to remove the catalyst. The filter cake was washed with methanol and the organic phases were combined and concentrated by evaporation. Subsequently, the concentrate was dissolved in ethanol (100 mL), p-toluenesulfonic acid (50 mg) was added and heated to reflux for 1 hour. At the end of the reaction, the mixture was poured into water and extracted with ethyl acetate, and the organic phase was dried over magnesium sulfate and concentrated by evaporation. Finally, the resulting solid was ground with hexane/ethyl acetate (95/5) mixed solvent to afford 4-fluoro-1,3-dihydro-2H-indol-2-one 1.7 g in 67% yield.
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1861 - 1873
[2] Patent: US2006/9509, 2006, A1. Location in patent: Page/Page column 10
4-Fluoro-1,3-dihydro-2H-indol-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Qi Qi hang Biotechnology Co., Ltd. | 18151111370 | 1046215251@qq.com | China | 5999 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| China DongFan Chemical Co.,LTD | 86-0571-85151182 | China | 5681 | 66 | |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| Shanghai Sphchem Co., Ltd. | 021-56491756 13512199871 | 2819742715@qq.com | China | 3994 | 55 |
| Shanghai Synthfine Chemical Co.,Ltd | 15921303235 | sales@synthfine.com | China | 999 | 58 |
| Shanghai ZaiQi Bio-Tech Co., Ltd. | 021-54824098, 021-37212705 021-37212706, 13391256916 | sales@chemzq.com | China | 569 | 55 |
View Latest Price from 4-Fluoro-1,3-dihydro-2H-indol-2-one manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-06-02 | 4-Fluorooxindole; 4-fluoroindolin-2-one; 4-Fluoro-1,3-dihydro-2H-indol-2-one in stock Factory
138343-94-9
|
$1.00 | 1kg | High quality purified Factory in China | Chemwill Asia Co.,Ltd. |
-
- 4-Fluorooxindole; 4-fluoroindolin-2-one; 4-Fluoro-1,3-dihydro-2H-indol-2-one in stock Factory
138343-94-9
- $1.00
- High quality purified Factory in China
- Chemwill Asia Co.,Ltd.
138343-94-9 (4-Fluoro-1,3-dihydro-2H-indol-2-one) Related Search:
1of4
