4,6-Difluoroindoline-2,3-dione
- CAS No.
- 126674-93-9
- Chemical Name:
- 4,6-Difluoroindoline-2,3-dione
- Synonyms
- 4,6-Difluoroisat;BUTTPARK 50\07-84;4,6-DIFLUOROISATIN;6-DIFLUOROINDOLINE-2;,6-DIFLUOROINDOLINE-2,3-DIONE;4,6-Difluoro-2,3-dioxoindoline;4,6-Difluoroindoline-2,3-dione;4,6-DifluorOoindoline-2,3-DIONE;1H-Indole-2,3-dione, 4,6-difluoro-;4,6-difluoro-2,3-dihydro-1H-indole-2,3-dione
- CBNumber:
- CB0103671
- Molecular Formula:
- C8H3F2NO2
- Molecular Weight:
- 183.11
- MDL Number:
- MFCD03618552
- MOL File:
- 126674-93-9.mol
- MSDS File:
- SDS
| Melting point | 218-220 °C |
|---|---|
| Density | 1.578 |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 7.65±0.20(Predicted) |
| Appearance | Light yellow to green yellow Solid |
| InChI | InChI=1S/C8H3F2NO2/c9-3-1-4(10)6-5(2-3)11-8(13)7(6)12/h1-2H,(H,11,12,13) |
| InChIKey | YIVXDNUTNIKQMY-UHFFFAOYSA-N |
| SMILES | N1C2=C(C(F)=CC(F)=C2)C(=O)C1=O |
| LogP | 1.13 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c |
| HS Code | 2933998090 |
4,6-Difluoroindoline-2,3-dione price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC900686 | 4,6-Difluoro-1H-indole-2,3-dione 97% | 126674-93-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC900686 | 4,6-Difluoro-1H-indole-2,3-dione 97% | 126674-93-9 | 5g | $24 | 2026-06-04 | Buy |
| Apolloscientific | PC900686 | 4,6-Difluoro-1H-indole-2,3-dione 97% | 126674-93-9 | 25g | $49 | 2026-06-04 | Buy |
| Apolloscientific | PC900686 | 4,6-Difluoro-1H-indole-2,3-dione 97% | 126674-93-9 | 100g | $188 | 2026-06-04 | Buy |
| Apolloscientific | PC900686 | 4,6-Difluoro-1H-indole-2,3-dione 97% | 126674-93-9 | 500g | $861 | 2026-06-04 | Buy |
4,6-Difluoroindoline-2,3-dione Chemical Properties, Uses, Production
Uses
4,6-DIFLUOROINDOLINE-2,3-DIONE, also known as 4,6-difluoroisatin, is a fluorinated derivative of indole. It is primarily used as a synthetic intermediate in the production of specialised pharmaceuticals and agrochemicals, such as anti-cancer Kras G12C inhibitors and CRHR2 antagonists for the treatment of chronic heart failure.
Synthesis
940054-61-5
126674-93-9
Stage 2: Synthesis of 4,6-difluoro-1H-indole-2,3-dione The product of stage 1, 2-hydroxyimino-N-(3,5-difluorophenyl)-acetamide (21.1 g, 105 mmol) was slowly added to concentrated sulfuric acid (115 ml) preheated to 50-60°C. After maintaining this temperature and stirring for 15 minutes, the reaction mixture was warmed up to 100°C and stirring was continued for 30 minutes. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice (1.2 kg). The precipitated solid was collected by filtration, washed to neutrality with plenty of water and finally dried in a desiccator using phosphorus pentoxide as desiccant. The yellow solid product 4,6-difluoro-1H-indole-2,3-dione was obtained 18.4 g in 95% yield. 1H-NMR (DMSO-d6) data: δ 6.60 (1H, dd, J = 8.8 and 2.0 Hz); 6.84 (1H, dt, J = 9.8 and 2.0 Hz); 11.20 (1H, br s).
References
[1] Patent: US2008/293749, 2008, A1. Location in patent: Page/Page column 14
4,6-Difluoroindoline-2,3-dione Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Changzhou Shili Pharmaceutical Technology Co., Ltd | 051988727299; 13961229012 | shitech@163.com | China | 299 | 58 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Carbott PharmTech Inc. | 0535-6385396 | info@carbottpharm.com | China | 996 | 56 |
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Nanjing Vital Chemical Co., Ltd. | Please Send Email 18652950785 | chemweiao@163.com | China | 4368 | 65 |
View Latest Price from 4,6-Difluoroindoline-2,3-dione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 4,6-Difluoro-1H-indole-2,3-dione
126674-93-9
|
$2.20-8.80 | 1kg | 99%min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-05-18 | 4,6-Difluoroisatin
126674-93-9
|
1kg | 98% | Hefei Lbao Physical & Chemical Science Co.,Ltd | |||
 |
2026-01-13 | 4,6-Difluoroindoline-2,3-Dione
126674-93-9
|
1KG | 97.0%min；99.0%min | Hangzhou Milon Pharmatech Co.,Ltd. |
-
- 4,6-Difluoro-1H-indole-2,3-dione
126674-93-9
- $2.20-8.80
- 99%min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 4,6-Difluoroisatin
126674-93-9
- $0.00
- 98%
- Hefei Lbao Physical & Chemical Science Co.,Ltd
-
- 4,6-Difluoroindoline-2,3-Dione
126674-93-9
- 97.0%min；99.0%min
- Hangzhou Milon Pharmatech Co.,Ltd.
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