7-Fluorooxindole
- CAS No.
- 71294-03-6
- Chemical Name:
- 7-Fluorooxindole
- Synonyms
- 7-FLUOROINDOLIN-2-ONE;2H-Indol-2-one;7-FLUOROOXINDOLE;7-Fluorooxindole97%;7-FLUORO-2-OXINDOLE;7-Fluorooxindole 97%;7-Fluoro-2-oxyindole;7-FLUOROINDOLE-2-ONE;Sunitinib Impurity 59;7-Fluoro-2-oxindole 97%
- CBNumber:
- CB6397166
- Molecular Formula:
- C8H6FNO
- Molecular Weight:
- 151.14
- MDL Number:
- MFCD02179608
- MOL File:
- 71294-03-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 188-190°C |
|---|---|
| Boiling point | 297.9±40.0 °C(Predicted) |
| Density | 1.311±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | Powder |
| pka | 12.93±0.20(Predicted) |
| color | Red-brown |
| InChI | InChI=1S/C8H6FNO/c9-6-3-1-2-5-4-7(11)10-8(5)6/h1-3H,4H2,(H,10,11) |
| InChIKey | VMUIOEOYZHJLEZ-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2F)CC1=O |
| LogP | 0.7 at 25℃ and pH6.8 |
| CAS DataBase Reference | 71294-03-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi,C,Xn | |||||||||
| Risk Statements | 36/37/38-34-22 | |||||||||
| Safety Statements | 26-36/37/39-45-27 | |||||||||
| Hazard Note | Irritant/Keep Cold | |||||||||
| HS Code | 2933790090 | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
7-Fluorooxindole price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 276104 | 7-Fluorooxindole Asreported | 71294-03-6 | 1g | $486 | 2026-06-03 | Buy |
| Usbiological | 276104 | 7-Fluorooxindole Asreported | 71294-03-6 | 2g | $616 | 2026-06-03 | Buy |
| Usbiological | 276104 | 7-Fluorooxindole Asreported | 71294-03-6 | 5g | $835 | 2026-06-03 | Buy |
| Usbiological | 276104 | 7-Fluorooxindole Asreported | 71294-03-6 | 10g | $1055 | 2026-06-03 | Buy |
| Usbiological | 276104 | 7-Fluorooxindole Asreported | 71294-03-6 | 25g | $1274 | 2026-06-03 | Buy |
7-Fluorooxindole Chemical Properties,Uses,Production
Uses
7-Fluorooxindole serves as a precursor for diazooxindole, which efficiently generates spirocyclic products[3].
Synthesis
872141-25-8
71294-03-6
The general procedure for the synthesis of 7-fluoro-2-indolone from 2-(3-fluoro-2-nitrophenyl)acetic acid was as follows: 2-(3-fluoro-2-nitrophenyl)acetic acid (9.6 g, 48 mmol) was dissolved in acetic acid (100 mL), 10% palladium-carbon catalyst (1.3 g) was added, and the hydrogenation reaction was carried out for 24 h at 50 psi hydrogen pressure. Upon completion of the reaction, the catalyst was filtered through Celite to remove the catalyst. Subsequently, the solvent in the reaction solution was removed by evaporation. The resulting residue was dissolved in ethanol (100 mL), p-toluenesulfonic acid (50 mg) was added, and the mixture was heated to reflux for 1 hour. The reaction solution was cooled, poured into water and extracted with ethyl acetate, the organic phase was dried with anhydrous magnesium sulfate and the solvent was evaporated. Finally, the solid obtained was ground with hexane/ethyl acetate (95/5, v/v) mixed solvent to give 7-fluoro-1,3-dihydro-indol-2-one (6 g, 83% yield).
References
[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 6, p. 1861 - 1873
[2] Patent: US2006/9509, 2006, A1. Location in patent: Page/Page column 9
[3]
Zhang, J., Wang, M., Wang, H., Xu, H., Chen, J., Guo, Z., Ma, B., Ban, S.-R., Dai, H.-X. (2021). Construction of 2-alkynyl aza-spiro[4,5]indole scaffolds via sequential C–H activations for modular click chemistry libraries. Chemical Communications, 57(69), 8656–8659. https://doi.org/10.1039/d1cc02798k
7-Fluorooxindole Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai URChem Limited | +86-021-50890968，021-50891159 +86-18601776121 | danny@urchem.com | China | 639 | 58 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
View Lastest Price from 7-Fluorooxindole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 7-Fluorooxindole
71294-03-6
|
$1.50-36.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2021-07-13 | 7-Fluorooxindole
71294-03-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd | ||
 |
2021-07-10 | 7-Fluorooxindole
71294-03-6
|
$10.00-15.00 | 1KG | 99%+ HPLC | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 7-Fluorooxindole
71294-03-6
- $1.50-36.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 7-Fluorooxindole
71294-03-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- 7-Fluorooxindole
71294-03-6
- $10.00-15.00
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
