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D(-)-AMETHOPTERIN

CAS No.
51865-79-3
Chemical Name:
D(-)-AMETHOPTERIN
Synonyms
R-Methotrexate;6-MTX(D);d-methotrexate;Einecs 257-482-2;D(-)-AMETHOPTERIN;R-Methotrexate;D-(-)-AMETHOPTERIN HYDRATE;Methotrexate Impurity 6(EP-F);Methotrexate Impurity F (Isomer);(-) - AMETHOPTERIN - D - METHOTREXATE
CBNumber:
CB9739301
Molecular Formula:
C20H22N8O5
Molecular Weight:
454.44
MDL Number:
MFCD00006710
MOL File:
51865-79-3.mol
MSDS File:
SDS
Last updated:2026-05-28 05:59:16

D(-)-AMETHOPTERIN Properties

Melting point 195 °C
Boiling point 561.26°C (rough estimate)
Density 1.4080 (rough estimate)
refractive index 1.6910 (estimate)
storage temp. -20°C
solubility Aqueous Base (Slightly, Heated, Sonicated), DMSO (Slightly), Methanol (Slightly)
pka 3.47±0.10(Predicted)
form Solid
color Dark Yellow to Very Dark Yellow
Stability Hygroscopic
Major Application pharmaceutical (small molecule)
InChIKey FPJYMUQSRFJSEW-UHFFFAOYSA-N
SMILES O.CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
EWG's Food Scores 1
FDA UNII W12798130R
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)Health Hazard (GHS08)
GHS06,GHS08
Signal word  Danger
Hazard statements  H301-H315-H319-H341-H360D
Precautionary statements  P202-P264-P270-P301+P310-P302+P352-P305+P351+P338
Hazard Codes  T
Risk Statements  61-46-25-36/37/38-60-23/24/25
Safety Statements  53-45-28A-36/37/39-26-22
RIDADR  UN 1544 6.1/PG 3
WGK Germany  WGK 3
RTECS  MA1224000
HS Code  29335995
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Irrit. 2
Muta. 2
Repr. 1B
Skin Irrit. 2

D(-)-AMETHOPTERIN price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1413988 (?)-Amethopterin United States Pharmacopeia (USP) Reference Standard 51865-79-3 5mg $1530 2026-04-30 Buy
TRC TRC-M260665-5MG (R)-Methotrexate 51865-79-3 5mg $951 2026-06-03 Buy
TRC TRC-M260665-25MG (R)-Methotrexate 51865-79-3 25mg $3793 2026-06-03 Buy
TRC TRC-M260665-1MG (R)-Methotrexate 51865-79-3 1mg $263 2026-06-03 Buy
Biosynth BCA86579 D-(-)-Amethopterin hydrate 51865-79-3 1mg $649 2026-06-04 Buy
Product number Packaging Price Buy
1413988 5mg $1530 Buy
TRC-M260665-5MG 5mg $951 Buy
TRC-M260665-25MG 25mg $3793 Buy
TRC-M260665-1MG 1mg $263 Buy
BCA86579 1mg $649 Buy

D(-)-AMETHOPTERIN Chemical Properties, Uses, Production

Chemical Properties

Solid

Uses

R-Methotrexate is an enantiomer of Methotrexate (M260675), a folic acid antagonist. Used as a antineoplastic and antirheumatic.

D(-)-AMETHOPTERIN Preparation Products And Raw materials

Raw materials

Preparation Products

D(-)-AMETHOPTERIN Suppliers

Global Suppliers ( 75)
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Daicel Chiral Technologies (China)CO.,LTD 021-50460086-9 15921403865 han_yajun@dctc.daicel.com China 7909 65
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 9920 65
S.Z. PhyStandard Bio-Tech. Co., Ltd. 0755-4000505016 13380397412 3001272453@qq.com China 5000 50
Quality Control Solutions Ltd. 0755-66853366 13670046396 orders@qcsrm.com China 18188 56
Finetech Industry Limited 027-87465837 19945049750 sales@finetechnology-ind.com China 9331 58
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656 greensnown@163.com China 9883 50
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Nanjing XiZe Biotechnology CO., Ltd. 025-66023220 15250997978 1511893459@qq.com China 4777 55
BOC Sciences 16314854226 info@bocsci.com United States 9909 65
d-methotrexate n-(4-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-d-glutamicacid D(-)-AMETHOPTERIN D-(-)-AMETHOPTERIN HYDRATE D(-)-4-AMINO-N10-METHYLPTEROYLGLUTAMIC ACID D-(-)-N-(2,4-diamino-6-pteridinyl(dimethylamino)benzoyl)glutamic acid R-Methotrexate (5 mg) ((R)-2-(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}benzamido)pentanedioic acid) Methotrexate Impurity 6(EP-F) D-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI) (-) - AMETHOPTERIN - D - METHOTREXATE 6-MTX(D) N-[4-[[(2,4-Diaminopteridin-6-yl)methyl]methylamino]benzoyl]-D-glutamic acid D-Glutamic acid, N-(4-(((2,4-diamino-6-pteridyl)methyl)methylamino)benzoyl)- Einecs 257-482-2 Glutamic acid, N-(p-(((2,4-diamino-6-pteridinyl)methyl)methylamino)benzoyl)-, D- D-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- Methotrexate Impurity 6(Methotrexate EP Impurity F) (4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino)benzoyl)-D-glutamic acid Methotrexate EP Impurity F Disodium Salt ((R)-Methotrexate Disodium Salt) MethotrexateEPImpurityFDisodiumSalt-MethotrexateDisodiumSalt) (R)-2-(4-(((2,4-diaminopteridin-6-yl)methyl)(methyl)amino) benzamido)pentanedioic acid R-Methotrexate Methotrexate Impurity F (Isomer) R-Methotrexate 51865-79-3 331717-13-2 C20H22N8O5