C6 ceramide
- CAS No.
- 124753-97-5
- Chemical Name:
- C6 ceramide
- Synonyms
- N-HEXANOYLSPHINGOSINE;N-HEXANOYL-D-ERYTHRO-SPHINGOSINE;CERAMIDE C6;C6 ceramide;06:0 CERAMIDE;CAPROYL CERAMIDE;C8 SPHINGOID BASE;Hexanoyl-sphingosine;C6-D-ERYTHRO-CERAMIDE;C6 Ceramide (d18:1/6:0)
- CBNumber:
- CB9744617
- Molecular Formula:
- C24H47NO3
- Molecular Weight:
- 397.64
- MDL Number:
- MFCD00870174
- MOL File:
- 124753-97-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 76-77°C |
|---|---|
| Boiling point | 521.03°C (rough estimate) |
| Density | 1.0077 (rough estimate) |
| refractive index | 1.6000 (estimate) |
| storage temp. | -20°C |
| solubility | Soluble in 100% ethanol at 25mg/ml and also in DMSO at 50mg/ml. |
| pka | 13.53±0.20(Predicted) |
| form | Powder |
| color | White |
| biological source | synthetic |
| Stability | Freezer -20°C |
| Cosmetics Ingredients Functions |
SKIN CONDITIONING HAIR CONDITIONING |
| InChI | 1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+ |
| InChIKey | NPRJSFWNFTXXQC-QFWQFVLDSA-N |
| SMILES | C(N[C@@H](CO)[C@H](O)/C=C/CCCCCCCCCCCCC)(=O)CCCCC |
| LogP | 7.463 (est) |
| FDA UNII | 038753E78J |
| UNSPSC Code | 12352211 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280-P261-P271 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| HS Code | 29241990 |
| Storage Class | 11 - Combustible Solids |
C6 ceramide price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 376650 | N-Hexanoyl-D-sphingosine | 124753-97-5 | 5mg | $104 | 2026-04-30 | Buy |
| Sigma-Aldrich | H6524 | N-Hexanoyl-D-sphingosine ≥98% (TLC), synthetic | 124753-97-5 | 1mg | $40.1 | 2023-06-20 | Buy |
| Cayman Chemical | 62525 | C6 Ceramide (d18:1/6:0) ≥98% | 124753-97-5 | 1mg | $20 | 2026-04-30 | Buy |
| Cayman Chemical | 62525 | C6 Ceramide (d18:1/6:0) ≥98% | 124753-97-5 | 5mg | $81 | 2026-04-30 | Buy |
| Cayman Chemical | 62525 | C6 Ceramide (d18:1/6:0) ≥98% | 124753-97-5 | 10mg | $123 | 2026-04-30 | Buy |
C6 ceramide Chemical Properties, Uses, Production
Description
C6 ceramide is a cell-permeable analog of naturally occurring ceramides. With a longer carbon chain than C2 ceramide, it is somewhat more hydrophobic, and may more closely mimic the effects of natural ceramides. C6 ceramide mediates many diverse biological activities including apoptosis, activation of protein phosphatase 2A, and inhibition of the mitochondrial respiratory chain. It also enhances the expression of COX-2 in rat granulosa cells and stimulates the growth of bovine aortic smooth muscle cells. C6 ceramide acts in neuronal axons to inhibit neurite growth.
Chemical Properties
Off White Powder
Uses
A biologically active, cell permeable, but nonphysiologic ceramide analog. It stimulates protein phosphatase 2A at concentrations as low as 10 nM and activiates MAP kinase. It induces apoptosis and inhibits glycoproptein traffic by the secretory pathway.
Uses
C6 Ceramide (d18:1/6:0) has been used as a chemotherapeutic agent to test its anti-tumor effect in breast cancer cells and ovarian cancer cell lines. It has also been used to test chemo-sensitization effects in cancer cells.
Definition
ChEBI: N-(hexanoyl)sphing-4-enine is an N-acylsphingosine consisting of sphing-4-enine bearing a hexanoyl group on nitrogen. It is functionally related to a sphing-4-enine.
General Description
Biologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G0/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.
Biochem/physiol Actions
C6 Ceramide (d18:1/6:0) is involved in inhibiting proliferation and inducing apoptosis. When used in combination with acid ceramidase inhibitor DM102, [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivaloylamide], it favors cell death in human breast cancer cells lines. C6 Ceramide may serve as an adjunct in chemotherapy. It elicits anti-tumor effects via AKT (serine/threonine-specific protein kinase) dephosphorylation and α-tubulin acetylation.
References
[1] R T DOBROWSKY Y A H. Ceramide stimulates a cytosolic protein phosphatase.[J]. The Journal of Biological Chemistry, 1992, 267 8: 5048-5051.
[2] R T DOBROWSKY. Ceramide activates heterotrimeric protein phosphatase 2A.[J]. The Journal of Biological Chemistry, 1993, 268 21: 15523-15530.
[3] P SANTANA. Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis.[J]. Endocrinology, 1996, 137 6: 2480-2489. DOI: 10.1210/endo.137.6.8641202
[4] E I DE CHAVES. Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons.[J]. The Journal of Biological Chemistry, 1997, 272 5: 3028-3035. DOI: 10.1074/jbc.272.5.3028
C6 ceramide Preparation Products And Raw materials
Raw materials
Preparation Products
C6 ceramide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Renshi Pharmatech Co., LTD | 021-61150625 18521367657 | info@renshipharma.com | China | 184 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
View Latest Price from C6 ceramide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-22 | C6 CERAMIDE
124753-97-5
|
1kg | 99% | 1000 kg | BINBOBIO CO., LTD. | ||
 |
2026-05-11 | C6 Ceramide
124753-97-5
|
$56.00-189.00 | 99.73% | 10g | TargetMol Chemicals Inc. |
-
- C6 CERAMIDE
124753-97-5
- $0.00
- 99%
- BINBOBIO CO., LTD.
-
- C6 Ceramide
124753-97-5
- $56.00-189.00
- 99.73%
- TargetMol Chemicals Inc.
124753-97-5 (C6 ceramide) Related Search:
1of4
