Prednisone
- CAS No.
- 53-03-2
- Chemical Name:
- Prednisone
- Synonyms
- PREDNISON;MOPP;Deltasone;Prednisone-d4;Prednisone Micronised;Pregna-1,4-diene-3,11,20-trione, 17,21-dihydroxy-;Cortan;Orasone;Paracort;Bicortone
- CBNumber:
- CB6716222
- Molecular Formula:
- C21H26O5
- Molecular Weight:
- 358.43
- MDL Number:
- MFCD00003608
- MOL File:
- 53-03-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 236-238 °C(lit.) |
|---|---|
| alpha | 169 º (c=0.5, dioxane) |
| Boiling point | 410.86°C (rough estimate) |
| Density | 1.1121 (rough estimate) |
| refractive index | 170 ° (C=0.5, Dioxane) |
| Flash point | >200℃ |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, slightly soluble in ethanol (96 per cent) and in methylene chloride. It shows polymorphism (5.9). |
| pka | 12.36±0.60(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | 115mg/L(25 ºC) |
| Merck | 7722 |
| BRN | 2065301 |
| Henry's Law Constant | 3.5×104 mol/(m3Pa) at 25℃, HSDB (2015) |
| BCS Class | 1 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Major Application | clinical testing |
| InChIKey | XOFYZVNMUHMLCC-ZPOLXVRWSA-N |
| SMILES | O[C@]1([C@@]2([C@H]([C@H]3[C@@H]([C@@]4(C(=CC(=O)C=C4)CC3)C)C(=O)C2)CC1)C)C(=O)CO |
| CAS DataBase Reference | 53-03-2(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | VB0R961HZT |
| NCI Dictionary of Cancer Terms | MOPP; prednisone |
| NCI Drug Dictionary | prednisone |
| ATC code | A07EA03,H02AB07 |
| Proposition 65 List | MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture) |
| NIST Chemistry Reference | Prednisone(53-03-2) |
| IARC | 3 (Vol. 26, Sup 7) 1987 |
| EPA Substance Registry System | Prednisone (53-03-2) |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H373 |
| Precautionary statements | P260 |
| Hazard Codes | Xn |
| Safety Statements | 36/37/39-45-26-16 |
| WGK Germany | WGK 2 |
| TSCA | TSCA listed |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 4 Dermal Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Irrit. 2 Flam. Liq. 2 |
| Hazardous Substances Data | 53-03-2(Hazardous Substances Data) |
Prednisone price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P6254 | Prednisone ≥98% | 53-03-2 | 1G | $48.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | P6254 | Prednisone ≥98% | 53-03-2 | 5G | $178 | 2026-04-30 | Buy |
| Sigma-Aldrich | Y0001921 | Prednisone for peak identification European Pharmacopoeia (EP) Reference Standard | 53-03-2 | 15 mg | $238 | 2026-04-30 | Buy |
| Sigma-Aldrich | PHR1042 | Prednisone Pharmaceutical Secondary Standard; Certified Reference Material | 53-03-2 | 1 g | $125 | 2026-04-30 | Buy |
| Sigma-Aldrich | P6254 | Prednisone ≥98% | 53-03-2 | 10G | $315 | 2026-04-30 | Buy |
Prednisone Chemical Properties, Uses, Production
Chemical Properties
White or almost white, crystalline powder.
History
The first isolation and structure identifications of prednisone and prednisolone were done in 1950 by Arthur Nobile. The first commercially feasible synthesis of prednisone was carried out in 1955 in the laboratories of Schering Corporation, which later became Schering-Plough Corporation, by Arthur Nobile and coworkers. They discovered that cortisone could be microbiologically oxidized to prednisone by the bacterium Corynebacterium simplex. Prednisone was introduced in 1955 by Schering, under the brand name Meticorten.
Prednisone was patented in 1954 and approved for medical use in the United States in 1955. In 2023, it was the 38th most commonly prescribed medication in the United States, with more than 15 million prescriptions.
Uses
Prednisone is used for the same indications as cortisone for inflammatory processes, allergies, and adrenal gland insufficiency; however, it is somewhat more active than cortisone and has less of an effect on mineral volume.
Uses
Adrenocortical steroid. Glucocorticoid, antiinflammatory.
Uses
Downregulates TNF-α production and NF-κB expression
Definition
ChEBI: A synthetic glucocorticoid drug that is particularly effective as an immunosuppressant, and affects virtually all of the immune system. Prednisone is a prodrug that is converted by the liver into prednisolone (a beta-hydroxy group instead f the oxo group at position 11), which is the active drug and also a steroid.
Indications
Prednisone 2.5 to 7.5 mg, administered at night or dexamethasone 0.25 to 0.75 mg are useful in female patients, with severe acne unresponsive to conventional therapy, who suffer from adrenal gland overproduction of androgens such as congenital adrenal hyperplasia.
brand name
Cortan (Halsey); Delta-Dome (Bayer); Deltasone (Pharmacia & Upjohn); Liquid Pred (Muro); Meticorten (Schering); Orasone (Solvay Pharmaceuticals); Paracort (Parke-Davis).
General Description
Odorless white crystalline powder.
General Description
Prednisone, Δ1-cortisone, 17,21-dihydroxypregna-1,4-diene-3,11,20-trione, has systemic activityvery similar to that of prednisolone, and because of itslower salt-retention activity, it is often preferred over cortisoneor hydrocortisone. Prednisone must be reduced in vivoto prednisolone to provide the active GC.
Air & Water Reactions
Very slightly water soluble .
Hazard
Questionable carcinogen.
Safety Profile
Poison by intraperitoneal and subcutaneous routes. Moderately toxic by intramuscular route. Human systemic effects: sensory change involving peripheral nerves, dermatitis. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. Has been implicated in aplastic anemia.
Synthesis
Prednisone is 17|á,21-dihydroxypregna-1,4-dien-3,11-20-trione (27.1.31). Prednisone differs from cortisone in the presence of an additional double bond between C1 and C2. There are various ways of synthesizing it. In one of these, as is in the case when synthesizing cortisone, it is synthesized from dihydrocortisone acetate. However, in the given example, this compound undergoes dibromination by molecular bromine, giving 2,4-dibromo-derivative of dihydrocortisone 27.1.30. Dehydrobromination with 3,5-lutidine, followed by subsequent hydrolysis of the acetyl group using potassium bicarbonate gives the desired prednisone (27.1.31). Prednisone is also synthesized by microbiological dehydrogenation of cortisone.
Purification Methods
Crystallise prednisone from acetone/hexane, then recrystallise it from Me2CO. The monoacetate crystallises from Me2CO/hexane with m 227-233o(dec), [] D +186o (c 1, dioxane), and the diacetate crystallises from 25Me2CO/hexane with m 219-221o(dec), [] D +125o (c 1, CHCl3). [Hertzog et al. Tetrahedron 18 581 1962, Beilstein 8 IV 3531.]
Prednisone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Lihua Pharmaceutical Co.,Ltd | -- | lihuad@hnlihua.com | China | 21 | 69 |
| Shanghai Boyle Chemical Co., Ltd. | 021-50182298 021-50180596 | sales@boylechem.com | China | 2202 | 55 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| TAIYUAN RHF CO.,LTD. | +86 351 7031519 | sales@RHFChem.com | China | 2334 | 56 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9409 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| LGM Pharma | 1-(800)-881-8210 | inquiries@lgmpharma.com | United States | 2110 | 70 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16307 | 64 |
View Latest Price from Prednisone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-24 | prednisone
53-03-2
|
$10.00 | 1box | 99.99 | 1000000box | Shanghai Zheng Peptide Plastic Co., Ltd. | |
 |
2026-09-24 | prednisone
53-03-2
|
$7.00-10.00 | 10VIAL | 99.9 | 20000 | Ningbo Qingteng Plastic Cost.,Ltd. | |
 |
2026-09-17 | Prednisone
53-03-2
|
$5.00 | 1Box | 99.9% | 10000000 | Hebei Jiafan Trading Company Limited |
-
- prednisone
53-03-2
- $10.00
- 99.99
- Shanghai Zheng Peptide Plastic Co., Ltd.
-
- prednisone
53-03-2
- $7.00-10.00
- 99.9
- Ningbo Qingteng Plastic Cost.,Ltd.
-
- Prednisone
53-03-2
- $5.00
- 99.9%
- Hebei Jiafan Trading Company Limited
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