Benzthiazide | 91-33-8

Benzthiazide Properties

Melting point	231-232° (U.S. patent); mp 238-239° (P'an)
Boiling point	680.6±65.0 °C(Predicted)
Density	1.4176 (rough estimate)
refractive index	1.6100 (estimate)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	9.57±0.20(Predicted)
color	White to Off-White
Water Solubility	2.8mg/L(room temperature)
InChI	1S/C15H14ClN3O4S3/c16-11-6-12-14(7-13(11)25(17,20)21)26(22,23)19-15(18-12)9-24-8-10-4-2-1-3-5-10/h1-7H,8-9H2,(H,18,19)(H2,17,20,21)
InChIKey	NDTSRXAMMQDVSW-UHFFFAOYSA-N
SMILES	NS(=O)(=O)c1cc2c(NC(CSCc3ccccc3)=NS2(=O)=O)cc1Cl
FDA UNII	1TD8J48L61
EPA Substance Registry System	2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide (91-33-8)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Danger
Hazard statements	H317-H334
Precautionary statements	P261-P280-P342+P311
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	26-36
WGK Germany	2
RTECS	DK8400000
Storage Class	11 - Combustible Solids
Hazard Classifications	Resp. Sens. 1 Skin Sens. 1
Hazardous Substances Data	91-33-8(Hazardous Substances Data)
Toxicity	LD50 in mice, rats (mg/kg): >5000, >10000 orally; 410, 422 i.v. (P'an)

Benzthiazide price More Price(28)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B7149	Benzthiazide	91-33-8	1g	$43.4	2026-04-30	Buy
Usbiological	262276	Benzthiazide	91-33-8	50mg	$419	2026-06-03	Buy
Usbiological	262276	Benzthiazide	91-33-8	100mg	$629	2026-06-03	Buy
Usbiological	262276	Benzthiazide	91-33-8	250mg	$952	2026-06-03	Buy
Usbiological	262276	Benzthiazide	91-33-8	500mg	$1480	2026-06-03	Buy

Product number	Packaging	Price	Buy
B7149	1g	$43.4	Buy
262276	50mg	$419	Buy
262276	100mg	$629	Buy
262276	250mg	$952	Buy
262276	500mg	$1480	Buy

Benzthiazide Chemical Properties,Uses,Production

Originator

Exna,Robins,US,1960

Uses

Benzthiazide is a diuretic, antihypertensive agent.

Definition

ChEBI: 7-Sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position 6 is substituted by chlorine and that at position 3 is substituted by a benzylsulfanylmethyl group. A diuretic, it is used to treat hypertension and edema.

Manufacturing Process

The preparation of the dihydro analog is as follows:
(A) Preparation of 3-Chloromethyl-6-Chloro-7-Sulfamyl-3,4-DihydroBenzothiadizine-1,1-Dioxide - To 8 ml of 40-50% chloroacetaldehyde aqueous solution and 7 ml of dimethylformamide are added 10 grams of 2,4- disulfamyl-5-chloroaniline. The mixture is heated on a steam bath for 2 hours after which it is concentrated at reduced pressure. The residue is triturated with water. The solid material is recrystallized from methanol-ether after treatment with activated carbon to give 7.2 grams of product, MP 229°- 230°C.
(B) Preparation of Benzylthiomethyl-6-Chloro-7-Sulfamyl-3,4- Dihydrobenzothiadiazine-1,1-Dioxide - A mixture of 3-(chloromethyl)-6-chloro- 7-sulfamyl-3,4-dihydrobenzothiadiazine-1,1-dioxide (0.02 mol) and benzylmercaptan (0.024 mol) in 20 ml of 10% sodium hydroxide and 20 ml of dimethylformamide is stirred at room temperature for 6 hours. After heating for 10 minutes on a steam bath, the mixture is cooled and acidified with 6 N HCl. The product, after recrystallization from acetone, melts at 210°-211°C.

brand name

Aquatag (Solvay Pharmaceuticals); Fovane (Pfizer).

Therapeutic Function

Diuretic, Antihypertensive

Safety Profile

Poison by intravenous route. Adiuretic and antihypertensive agent. When heated todecomposition it emits very toxic fumes of SOx, NOx, andCl^-.

Benzthiazide Preparation Products And Raw materials

Raw materials

Chloroacetaldehyde Benzyl mercaptan

Preparation Products

Benzthiazide Suppliers

Global( 92)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Tianjin heowns Biochemical Technology Co., Ltd.	400 638 7771	sales@heowns.com	China	14412	57
Beijing HuaMeiHuLiBiological Chemical	010-56205725	waley188@sohu.com	China	12323	58
Shanghai Kewel Chemical Co., Ltd.	021-64609169 18901607656	greensnown@163.com	China	9883	50
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Hubei Yangxin Medical Technology Co., Ltd.	15374522761	3003392093@yongstandards.com	China	9995	55
Tianjin heowns Biochemical Technology Co., Ltd.	400-6387771-6039 18920764717	sales@heowns.com	China	24636	60

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Chemsky（shanghai）International Co.,Ltd.	50
Tianjin heowns Biochemical Technology Co., Ltd.	57
Beijing HuaMeiHuLiBiological Chemical	58
Shanghai Kewel Chemical Co., Ltd.	50
Sigma-Aldrich	80
Shanghai YuanYe Biotechnology Co., Ltd.	60
Hubei Yangxin Medical Technology Co., Ltd.	55
Tianjin heowns Biochemical Technology Co., Ltd.	60

View Lastest Price from Benzthiazide manufacturers

Update time	Product	Price	Purity	Supply Ability	Manufacturer
2026-07-27	Benzthiazide 91-33-8	$39.00	99.77%	10g	TargetMol Chemicals Inc.
2026-07-27	Benzthiazide 91-33-8	$39.00	99.77%	10g	TargetMol Chemicals Inc.
2026-07-27	Benzthiazide 91-33-8	$39.00	99.77%	10g	TargetMol Chemicals Inc.

Benzthiazide
91-33-8
$39.00
99.77%
TargetMol Chemicals Inc.

Benzthiazide
91-33-8
$39.00
99.77%
TargetMol Chemicals Inc.

Benzthiazide
91-33-8
$39.00
99.77%
TargetMol Chemicals Inc.

Benzthiazide Spectrum

BENZTHIAZIDE(91-33-8)¹HNMR

91-33-8(Benzthiazide)Related Search:

Benzthiazide Clofenamide 2-(Benzylthio)ethylamine hydrochloride 2-Methylsulfanyl-acetamidine 4-Chloro-1,3-benzenedithiol

2-Amino-N-methylbenzenesulfonamide Xylazine Hydrochloride hydrobentizide Xylazine Chlorothiazide

4-Chloro-N-methylbenzenesulphonamide 4-Amino-6-chlorobenzene-1,3-disulfonamide 2H-1,2,4-Benzothiadiazine 1,1-dioxide 2-Aminobenzenesulfonamide

1of3

6-Chloro-3-[[(phenylMethyl)thio]Methyl]-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide ((benzylthio)methyl)-3chloro-6dioxyde-1,1sulfonamide-7benzothiadiazine-1,2, -1,-dioxide 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3-((benzylthio)methyl)-6-chloro-, 1,1-dioxide 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(((phenylmethyl)thio)methyl)-, dioxide 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-[[(phenylmethyl)thio]methyl]-, 1,1-dioxide 2h-1,2,4-benzothiadiazine-7-sulfonamide,3-((benzylthio)menthyl)-6-chloro-,1,1 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3-(((phenylmethyl)thio)methyl 3-((Benzylthio)methyl)-6-chloro-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 3-((benzylthio)methyl)-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dio 3-[(Benzylsulfanyl)methyl]-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 3-[(benzylthio)methyl]-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dio 3-[(benzylthio)methyl]-6-chloro-7-sulfamoyl-2h-benzo-1,2,4-thiadiazine1,1-diox 3-Benzylthiomethyl-6-chloro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 3-benzylthiomethyl-6-chloro-2h-1,2,4-benzothiadiazine-7-sulfonamide1,1-dioxi 3-Benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine 1,1-dioxide 3-benzylthiomethyl-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine1,1-dioxide 4-benzothiadiazine-7-sulfonamide,3-((benzylthio)methyl)-6-chloro-,1,1-2h-2 4or6-chloro-2-phenylphenol 6-chloro-3-(((phenylmethyl)thio)methyl)-2h-1,2,4-benzothiadiazine-7-sulfonamide 6-chloro-3-[[(phenylmethyl)thio]methyl]-2h-1,2,4-benzothiadiazine-7-sulfonamid 6-chloro-7-sulfamoyl-3-benzylthiomethyl-2h-1,2,4-benzothiadiazine1,1-dioxide Aquatag Dihydrex Diucen diucene Edemex Exosalt exva fouane Fovane Freeuril HyDrine hy-drine Lemazide P 1393 p1393 Pfizer 1393 pfizer1393 Proaqua regulon Urese Exsalt 3-[(benzylthio)methyl]-6-chloro-1,1-diketo-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 6-chloro-1,1-dioxo-3-(phenylmethylsulfanylmethyl)-4H-benzo[e][1,2,4]thiadiazine-7-sulfonamide CHEMBANK1114 BENZTHIAZIDE USP/EP/BP 3-((Benzylthio)methyl)-6-chloro-2H-benzo[e][1,2,4]thiadiazine-7-sulfonamide 1,1-dioxide Inhibitor,Carbonate dehydratase,Carbonic Anhydrase,Benzthiazide,inhibit Hydrochlorothiazide Impurity 31 (Benzthiazide) Benzthiazide, 10 mM in DMSO Benzothiazide Exna Benzthiazide 91-33-8 C15H14ClN3O4S3 43194 Heterocyclic Building Blocks