7-chloro-1H-indole-2-carboxylic acid
- CAS No.
- 28899-75-4
- Chemical Name:
- 7-chloro-1H-indole-2-carboxylic acid
- Synonyms
- 7-Chloroindole-2-carboxylic acid;1H-Indole-2-carboxylic acid, 7-chloro-;7-Chloro-1H-indole-2-carboxylic acid;7-chloro-1H-indole-2-carboxylic acid(SALTDATA: FREE)
- CBNumber:
- CB9895577
- Molecular Formula:
- C9H6ClNO2
- Molecular Weight:
- 195.6
- MDL Number:
- MFCD02664428
- MOL File:
- 28899-75-4.mol
- MSDS File:
- SDS
| Boiling point | 449.7±25.0 °C(Predicted) |
|---|---|
| Density | 1.548±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 4.23±0.30(Predicted) |
| form | solid |
| Appearance | White to off-white Solid |
| InChI | InChI=1S/C9H6ClNO2/c10-6-3-1-2-5-4-7(9(12)13)11-8(5)6/h1-4,11H,(H,12,13) |
| InChIKey | NVKAHBFPKVINGE-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2Cl)C=C1C(O)=O |
| UNSPSC Code | 12352106 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335-H302 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 2933998090 |
| Storage Class | 11 - Combustible Solids |
7-chloro-1H-indole-2-carboxylic acid price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | OR906974 | 7-Chloro-1H-indole-2-carboxylic acid 97% | 28899-75-4 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR906974 | 7-Chloro-1H-indole-2-carboxylic acid 97% | 28899-75-4 | 1g | $22 | 2026-06-04 | Buy |
| Apolloscientific | OR906974 | 7-Chloro-1H-indole-2-carboxylic acid 97% | 28899-75-4 | 5g | $96 | 2026-06-04 | Buy |
| Apolloscientific | OR906974 | 7-Chloro-1H-indole-2-carboxylic acid 97% | 28899-75-4 | 25g | $448 | 2026-06-04 | Buy |
| Apolloscientific | OR906974 | 7-Chloro-1H-indole-2-carboxylic acid 97% | 28899-75-4 | 100g | $1741 | 2026-06-04 | Buy |
7-chloro-1H-indole-2-carboxylic acid Chemical Properties, Uses, Production
Uses
7-chloro-1H-indole-2-carboxylic acid is an important pharmaceutical intermediate compound used in the preparation of protease inhibitors.
Synthesis
A mixture of 111.5 g of 7-chloroindole-2-carboxylate in 31.25 g of 96percent sodium hydroxide in 183 ml of methanol and 183 ml of water were heated under reflux for 1 hour, cooled to 45 ° C, and 10 percent hydrochloric acid was added dropwise to a pH of 3 to 4. The mixture was sufficiently cooled to obtain 89.7 g of product as an off-white 7-chloro-1H-indole-2-carboxylic acid.
References
[1] Journal of Medicinal Chemistry, 2003, vol. 46, # 19, p. 3957 - 3960
[2] Patent: CN104402795, 2017, B. Location in patent: Paragraph 0060; 0063
[3] Journal of the Chemical Society, 1955, p. 3499,3502
[4] Patent: US2003/207893, 2003, A1
[5] Patent: WO2004/22061, 2004, A1. Location in patent: Page/Page column 56-57
7-chloro-1H-indole-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu AiQun Pharmaceutical Technology Co., Ltd. | 028-82393420 18108156287 | 2982653826@qq.com | China | 624 | 58 |
| Zhanhua Huibang Chemical Co., Ltd. | 13906149256 | 793211102@qq.com | China | 152 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Wuhan TCASChem Technology Co., Ltd. | 027-86697669 13986148687 | sales@tcaschem.com | China | 3997 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Changzhou Qinuo Chemical Co., Ltd.Co., Ltd. | 0519-0519-83812535 | sales@qinuochem.com | China | 287 | 60 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Tianjin Anhao Biological Technology Co., Ltd. | sales@ahpharmatech.com | China | 5734 | 55 |
View Latest Price from 7-chloro-1H-indole-2-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-07 | 7-chloro-1H-indole-2-carboxylic acid
28899-75-4
|
98% Min. | 200 | SHANDONG OUCHEM CO.,LTD. |
-
- 7-chloro-1H-indole-2-carboxylic acid
28899-75-4
- 98% Min.
- SHANDONG OUCHEM CO.,LTD.
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