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3'-methoxypropiophenone

3'-methoxypropiophenone Structure
3'-methoxypropiophenone structure
CAS No.
37951-49-8
Chemical Name:
3'-methoxypropiophenone
Synonyms
3-methoxypropiophenone;m-Methoxypropiophenone;3'-Methoxypropiophenone;3-Methoxyphenyl ethyl ketone;3'-Methoxypropiophenone, 99%;1-(3-Methoxyphenyl)-1-propanone;1-(3-methoxy-phenyl)propan-1-one;1-Propanone, 1-(3-methoxyphenyl)-
CBNumber:
CB9910779
Molecular Formula:
C10H12O2
Molecular Weight:
164.2
MDL Number:
MFCD08458823
MOL File:
37951-49-8.mol
Last updated:2026-05-28 04:55:55
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3'-methoxypropiophenone Properties

Boiling point 259℃
Density 1.0812
refractive index 1.5230 (estimate)
storage temp. Sealed in dry,Room Temperature
Appearance Colorless to light yellow Liquid
InChI InChI=1S/C10H12O2/c1-3-10(11)8-5-4-6-9(7-8)12-2/h4-7H,3H2,1-2H3
InChIKey LPDJHUUWTGXTCU-UHFFFAOYSA-N
SMILES C(C1=CC=CC(OC)=C1)(=O)CC

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H332-H319-H315-H302
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P261-P271-P304+P340-P312
HS Code  2914500090
REACH Registrations Active

3'-methoxypropiophenone price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR906997 3'-Methoxypropiophenone 98% 37951-49-8 25g $21 2026-06-04 Buy
Apolloscientific OR906997 3'-Methoxypropiophenone 98% 37951-49-8 100g $24 2026-06-04 Buy
Apolloscientific OR906997 3'-Methoxypropiophenone 98% 37951-49-8 500g $112 2026-06-04 Buy
Apolloscientific OR906997 3'-Methoxypropiophenone 98% 37951-49-8 1kg $221 2026-06-04 Buy
AK Scientific W5873 3'-Methoxypropiophenone 98%(GC) 37951-49-8 25g $16 2026-06-04 Buy
Product number Packaging Price Buy
OR906997 25g $21 Buy
OR906997 100g $24 Buy
OR906997 500g $112 Buy
OR906997 1kg $221 Buy
W5873 25g $16 Buy

3'-methoxypropiophenone Chemical Properties,Uses,Production

Chemical Properties

3'-methoxypropiophenone is an organic compound belonging to the ketone class of compounds. It is a yellow to yellow brown liquid with a boiling point of 259 °C. 

Uses

3'-methoxypropiophenone has a wide range of applications in the fields of medicine, chemistry, and industry.

Preparation

Preparation by reaction of ethylmagnesium bromide,
with m-methoxybenzonitrile (m.p. 60°)
with 3-methoxybenzaldehyde and oxidation of the resulting 1-(3-methoxyphenyl)-1-propanol with sodium dichromate in sulfuric acid (70%).

Synthesis

Ethylmagnesium bromide

925-90-6

3,N-DIMETHOXY-N-METHYLBENZAMIDE

152121-82-9

3'-methoxypropiophenone

37951-49-8

Under argon protection, 3,N-dimethoxy-N-methylbenzamide (5.86 g, 30.0 mmol) was dissolved in THF (150 mL) and cooled to 0°C. Slowly add ethylmagnesium bromide (0.960 mol/L THF solution, 100 mL, 96.0 mmol). After addition, bring to room temperature and stir for 3.5 hours. Upon completion of the reaction, the reaction was quenched with 1 mol/L hydrochloric acid and subsequently extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and saturated saline, and dried over anhydrous sodium sulfate. Concentration under reduced pressure afforded m-methoxypropiophenone (4.93 g, 30.0 mmol, quantitative yield) as a yellow oil.1H-NMR (400 MHz, CDCl3): δ 1.23 (3H, t, J = 7.3 Hz), 3.00 (2H, q, J = 7.3 Hz), 3.86 (3H, s), 7.10 (1H, dd, J = 7.9 , 2.4 Hz), 7.37 (1H, t, J = 7.9 Hz), 7.50 (1H, t, J = 2.4 Hz), 7.54 (1H, d, J = 7.9 Hz).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 1, p. 375 - 381
[2] Patent: WO2007/62190, 2007, A2. Location in patent: Page/Page column 29; 30
[3] Patent: WO2007/62145, 2007, A2. Location in patent: Page/Page column 41
[4] Patent: WO2007/44796, 2007, A2. Location in patent: Page/Page column 35-36
[5] Angewandte Chemie - International Edition, 2016, vol. 55, # 52, p. 16115 - 16118

3'-methoxypropiophenone synthesis

925-90-6
152121-82-9
37951-49-8
Synthesis of 3'-methoxypropiophenone from Ethylmagnesium bromide and 3,N-DIMETHOXY-N-METHYLBENZAMIDE

3'-methoxypropiophenone Preparation Products And Raw materials

Raw materials

3'-Hydroxypropiophenone 3,N-DIMETHOXY-N-METHYLBENZAMIDE 3-Methoxybenzonitrile Benzenemethanol, α-?ethenyl-?3-?methoxy- 3-Bromoanisole
Propionitrile Ethylmagnesium bromide Iodomethane Tetrahydrofuran Hydrochloric acid

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Preparation Products

1-(3-Methoxyphenyl)-2-Methylpropan-1-ol (S)-3-(dimethylamino)-1-(3-methoxyphenyl)-2-methylpropan-1-one

3'-methoxypropiophenone Suppliers

Global( 196)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Luowan Biological Technology Co., Ltd. 13646143635;18069669245 617837247@qq.com China 142 58
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Accela ChemBio Co.,Ltd. 021-50795510 4000665055 marketing@accelachem.com China 10972 64
Shanghai Harvest Chemical Industrial Co., Ltd. 15721252604 17321035817 sales@harvest-chem.com China 2829 64
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Syntechem Co.,Ltd info@syntechem.com China 12973 57
Nanjing Vital Chemical Co., Ltd. Please Send Email 18652950785 chemweiao@163.com China 4368 65
Supplier Advantage
Changzhou Luowan Biological Technology Co., Ltd. 58
Energy Chemical 61
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Jia Xing Isenchem Co.,Ltd 66
Accela ChemBio Co.,Ltd. 64
Shanghai Harvest Chemical Industrial Co., Ltd. 64
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57
Syntechem Co.,Ltd 57
Nanjing Vital Chemical Co., Ltd. 65

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View Lastest Price from 3'-methoxypropiophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3'-methoxypropiophenone pictures 2026-09-02 3'-methoxypropiophenone
37951-49-8
 $1.10-32.00 1kg 99% Henan Fengda Chemical Co., Ltd
3'-methoxypropiophenone pictures 2026-06-30 3'-methoxypropiophenone
37951-49-8
 1kg 99% 10000KGS Shaanxi Dideu New Materials Co. Ltd
3'-methoxypropiophenone pictures 2026-05-28 3'-methoxypropiophenone
37951-49-8
 $2.00-5.00 1KG 99% 10000kg Hebei Chuanghai Biotechnology Co,.LTD

3'-methoxypropiophenone Spectrum

3'-methoxypropiophenone(37951-49-8)1HNMR

37951-49-8(3'-methoxypropiophenone)Related Search:

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1-(3-methoxy-phenyl)propan-1-one 1-(3-Methoxyphenyl)-1-propanone 1-Propanone, 1-(3-methoxyphenyl)- 3'-Methoxypropiophenone 3'-Methoxypropiophenone, 99% 3-methoxypropiophenone 3-Methoxyphenyl ethyl ketone m-Methoxypropiophenone 37951-49-8