4-Bromothiophene-2-carbonitrile
- CAS No.
- 18791-99-6
- Chemical Name:
- 4-Bromothiophene-2-carbonitrile
- Synonyms
- 4-Bromo-2-cyanothiophene;4-Bromo-2-cyanothiophene >4-Bromothiophene-2-carbonitrile;2-Thiophenecarbonitrile,4-broMo-;4-Bromothiophene-2-carbonitrile98%;4-Bromothiophene-2-carbonitrile 98%;4-Bromothiophene-2-carbonitrile ISO 9001：2015 REACH
- CBNumber:
- CB9956384
- Molecular Formula:
- C5H2BrNS
- Molecular Weight:
- 188.05
- MDL Number:
- MFCD00114951
- MOL File:
- 18791-99-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 47.0 to 51.0 °C |
|---|---|
| Boiling point | 230.4±20.0 °C(Predicted) |
| Density | 1.82±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | powder to crystal |
| color | White to Light yellow |
| InChI | 1S/C5H2BrNS/c6-4-1-5(2-7)8-3-4/h1,3H |
| InChIKey | DJYVXBJLHPKUKS-UHFFFAOYSA-N |
| SMILES | Brc1csc(c1)C#N |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335 |
| Precautionary statements | P261-P280-P305+P351+P338 |
| target organs | Respiratory system |
| Hazard Codes | Xi,Xn |
| Risk Statements | 22-37/38-41 |
| Safety Statements | 26-39 |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 2934999090 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Inhalation Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
4-Bromothiophene-2-carbonitrile price More Price(57)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | B4212 | 4-Bromo-2-cyanothiophene >98.0%(GC) | 18791-99-6 | 1g | $46 | 2026-04-30 | Buy |
| TCI Chemical | B4212 | 4-Bromo-2-cyanothiophene >98.0%(GC) | 18791-99-6 | 5g | $205 | 2021-12-16 | Buy |
| Biosynth | TAA79199 | 4-Bromothiophene-2-carbonitrile | 18791-99-6 | 25g | $295 | 2026-06-05 | Buy |
| Apolloscientific | OR11486 | 4-Bromothiophene-2-carbonitrile 98% | 18791-99-6 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS143806 | 4-Bromothiophene-2-carbonitrile 98% | 18791-99-6 | 1g | $24 | 2026-06-04 | Buy |
4-Bromothiophene-2-carbonitrile Chemical Properties, Uses, Production
Synthesis
18791-75-8
18791-99-6
The general procedure for the synthesis of 4-bromothiophene-2-carbonitrile from 4-bromo-2-thiophenecarboxaldehyde was as follows: 4-bromothiophene-2-carboxaldehyde (600 g, 3.14 mmol) and hydroxylamine hydrochloride (438 g, 6.30 mmol) were dissolved in pyridine (5 L). After the reaction mixture was cooled to room temperature, it was heated to 90 °C and maintained for 10 min. Subsequently, acetic anhydride (1940 g, 19.0 mmol) was slowly added dropwise and the reaction system was heated to 80°C for 1 hour. After completion of the reaction, the mixture was poured into water (20 L) and stirred for 30 min. After filtration and drying, the target product 4-bromothiophene-2-carbonitrile (564 g, 95% yield) was obtained.
References
[1] Patent: CN104230960, 2017, B. Location in patent: Paragraph 0449; 0450; 0451
[2] Bioorganic and Medicinal Chemistry Letters, 2000, vol. 10, # 5, p. 415 - 418
[3] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 11, p. 2870 - 2875
[4] Patent: US2017/151225, 2017, A1. Location in patent: Paragraph 0926; 0927
4-Bromothiophene-2-carbonitrile Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1998 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 18201 | 56 |
View Latest Price from 4-Bromothiophene-2-carbonitrile manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 4-Bromothiophene-2-carbonitrile
18791-99-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2024-02-23 | 4-Bromo-2-cyanothiophene
18791-99-6
|
$530.00 | 1g | 98 | 500 Kg | R&D Scientific Inc. | |
 |
2020-01-13 | 4-Bromothiophene-2-carbonitrile
18791-99-6
|
$1.00 | 1g | 99.0% | 100kg | Career Henan Chemical Co |
-
- 4-Bromothiophene-2-carbonitrile
18791-99-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 4-Bromo-2-cyanothiophene
18791-99-6
- $530.00
- 98
- R&D Scientific Inc.
-
- 4-Bromothiophene-2-carbonitrile
18791-99-6
- $1.00
- 99.0%
- Career Henan Chemical Co
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