β-Estradiol manufacturers and suppliers

β-Estradiol suppliers

Properties

Melting point:: 178-179 °C(lit.)

alpha: D25 +76 to +83° (dioxane)

Boiling point:: 355.44°C (rough estimate)

Density: 1.0708 (rough estimate)

refractive index: 80.4 ° (C=1, Dioxane)

Flash point:: 2℃

storage temp.: room temp

solubility: Practically insoluble in water, soluble in acetone, sparingly soluble in ethanol (96 per cent), slightly soluble in methylene chloride.

pka: pKa 10.71±0.02(H2O(0.1% p-dioxane) t=25±0.1 I=0.03(KCl))(Approximate)

form: powder

color: White to off-white

biological source: synthetic (organic)

Water Solubility: Soluble in dimethyl sulfoxide, ethanol , water, phosphate buffer saline, dimethyl formamide, acetone, dioxane and alkali hydroxides. Slightly soluble in vegetable oils.

Merck: 14,3703

BRN: 1914275

Henry's Law Constant: 2.7×10⁵ mol/(m³Pa) at 25℃, HSDB (2015)

BCS Class: 1

Stability:: Stable. Incompatible with strong oxidizing agents.

Cosmetics Ingredients Functions: SKIN CONDITIONING

InChI: 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChIKey: VOXZDWNPVJITMN-ZBRFXRBCSA-N

SMILES: O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C

CAS DataBase Reference: 50-28-2(CAS DataBase Reference)

NIST Chemistry Reference: Estra-1,3,5(10)-triene-3,17beta-diol(50-28-2)

EPA Substance Registry System: Estradiol (50-28-2)

Safety Information

Symbol(GHS): GHS08,GHS09

Signal word: Danger

Hazard statements: H351-H360FD-H362-H410

Precautionary statements: P202-P260-P263-P264-P273-P308+P313

PPE: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes: T,Xn,F

Risk Statements: 60-61-45-63-64-40-36-20/21/22-11-48

Safety Statements: 53-22-36/37/39-45-36/37-26-16-36-20

RIDADR: 2811

WGK Germany: 3

RTECS: KG2975000

F: 8-10

HazardClass: 6.1

PackingGroup: III

HS Code: 29372390

Storage Class: 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications: Aquatic Acute 1
Aquatic Chronic 1
Carc. 2
Lact.
Repr. 1A

Hazardous Substances Data: 50-28-2(Hazardous Substances Data)

Toxicity: LD50 subcutaneous in rat: > 300mg/kg

REACH Registrations: Active

Use

β-Estradiol is an endogenous estrogenic hormone receptor (ER) agonist (Ki values are 0.12 and 0.13 nM for ERα and ERβ respectively). Also high affinity ligand at membrane estrogen GPR30 receptors. β-Estradiol is an activator of PI 3-kinase.Estradiol (17β-estradiol, β-Estradiol, E2, 17β-Oestradiol) is a human sex hormone and steroid, and the primary female sex hormone. Estradiol upregulates IL-6 expression through the estrogen receptor β (ERβ) pathway.

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