Torasemide manufacturers and suppliers

Torasemide suppliers

Properties

Melting point:: 163-164°C

Density: 1.283±0.06 g/cm3(Predicted)

storage temp.: Keep in dark place,Inert atmosphere,Room temperature

solubility: DMSO: soluble18mg/mL

pka: 6.44(at 25℃)

form: solid

color: White

Water Solubility: Soluble

Merck: 14,9552

BCS Class: 1

InChI: InChI=1S/C16H20N4O3S/c1-11(2)18-16(21)20-24(22,23)15-10-17-8-7-14(15)19-13-6-4-5-12(3)9-13/h4-11H,1-3H3,(H,17,19)(H2,18,20,21)

InChIKey: NGBFQHCMQULJNZ-UHFFFAOYSA-N

SMILES: C1=NC=CC(NC2=CC=CC(C)=C2)=C1S(NC(NC(C)C)=O)(=O)=O

CAS DataBase Reference: 56211-40-6(CAS DataBase Reference)

EPA Substance Registry System: 3-Pyridinesulfonamide, N-[[(1-methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]- (56211-40-6)

Safety Information

Symbol(GHS): GHS07,GHS08

Signal word: Warning

Hazard statements: H319-H361fd

Precautionary statements: P201-P202-P264-P280-P305+P351+P338-P308+P313

PPE: dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes: Xi

Risk Statements: 36-36/37/38

Safety Statements: 26-37/39

WGK Germany: 2

RTECS: UT7938000

HS Code: 2935904000

Storage Class: 11 - Combustible Solids

Hazard Classifications: Eye Irrit. 2
Repr. 2

Use

Torasemide is a novel loop diuretic launched in 1993 after a 12-year gap from the last diuretic introduction. It is indicated for the treatment of hypertension and edema associated with chronic congestive heart failure, renal disease and hepatic cirrhosis. Torasemide exerts its major diuretic activity on the thick ascending limb of the Henle's loop to promote rapid and marked excretion of water, Na+, Cl-, and to a lesser extent,K+ and Ca2+. Compared with other loop diuretics such as furosemide, torasemide has a stronger antihypertensive action, a higher bioavailability, a longer duration of action that is independent of the renal function, and has no side effects such as paradoxical antidiuresis. The mechanism of its vasodilating effect has been suggested to result from, at least in part, the competitive antagonism of the thromboxane A2 receptor.

You can find Torasemide suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.