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ChemicalBook >> CAS DataBase List >> 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile

4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile price.
  • $12 - $2194.5
  • Product name: 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
  • CAS: 500287-72-9
  • MF: C22H18N6
  • MW: 366.42
  • EINECS:
  • MDL Number:MFCD11046372
  • Synonyms:4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile;(E)-4-(4-(4-(2-cyanovinyl)-2,6-diMethylphenylaMino)pyriMidin-2-ylaMino)benzonitrile;4-[[4-[[4-[(E)-2-Cyanovinyl]-2,6-diMethylphenyl]aMino]pyriMidin-2-yl]aMino]benzonitrile;4-{[4-({4-[(1E)-2-cyanoeth-1-en-1-yl]-2,6-diMethylphenyl}aMino)pyriMidin-2-yl]aMino}benzonitrile;Rilpivirine(R 278474;Rilpivirine (R 278474, TMC 278);4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile;R 278474
Price72 Properties Safety Information Description
72 prices
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  • aablocks
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  • Adipogen Life Sciences
  • AK Scientific
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  • American Custom Chemicals Corporation
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  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
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  • Matrix Scientific
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  • Usbiological
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 10mM*1mLinDMSO(Solution)
  • 1000mg
  • 10mM(in1mLDMSO)
  • 2.5mg
  • 500mg
  • 50.00g
  • 100.00g
  • 250.00g
  • 10mM*1mLinDMSO
  • 10mM(in 1mL DMSO)
  • 1mg
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  • 50mg
  • 100mg
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  • 1g
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  • Manufactureraablocks
  • Product numberAA00DB4J
  • Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%
  • Packaging1mg
  • Price$17
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DB4J
  • Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile ≥98%
  • Packaging10mg
  • Price$18
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DB4J
  • Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC)
  • Packaging25mg
  • Price$32
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DB4J
  • Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%
  • Packaging50mg
  • Price$53
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DB4J
  • Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC)
  • Packaging100mg
  • Price$68
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DB4J
  • Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC)
  • Packaging250mg
  • Price$128
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DB4J
  • Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97%
  • Packaging1g
  • Price$296
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DB4J
  • Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97%
  • Packaging5g
  • Price$1063
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DB4J
  • Product description4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97%
  • Packaging10g
  • Price$1653
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product number10410
  • Product descriptionRilpivirine 98%
  • Packaging5G
  • Price$850
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10410
  • Product descriptionRilpivirine 98%
  • Packaging1G
  • Price$240
  • Updated2026-05-27
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  • ManufacturerACHEMBLOCK
  • Product number10410
  • Product descriptionRilpivirine 98%
  • Packaging100MG
  • Price$55
  • Updated2026-05-27
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3750-M005
  • Product descriptionRilpivirine ≥98%(HPLC)
  • Packaging5mg
  • Price$50
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3750-M025
  • Product descriptionRilpivirine ≥98%(HPLC)
  • Packaging25mg
  • Price$200
  • Updated2021-12-16
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3750-M025
  • Product descriptionRilpivirine ≥98%(HPLC)
  • Packaging25mg
  • Price$200
  • Updated2026-05-06
  • Buy
  • ManufacturerAdipogen Life Sciences
  • Product numberAG-CR1-3750-M100
  • Product descriptionRilpivirine ≥98%(HPLC)
  • Packaging100mg
  • Price$430
  • Updated2026-05-06
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00DB4J 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98% 1mg $17 2026-05-28 Buy
aablocks AA00DB4J 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile ≥98% 10mg $18 2026-05-28 Buy
aablocks AA00DB4J 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC) 25mg $32 2026-05-28 Buy
aablocks AA00DB4J 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98% 50mg $53 2026-05-28 Buy
aablocks AA00DB4J 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC) 100mg $68 2026-05-28 Buy
aablocks AA00DB4J 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 98%(HPLC) 250mg $128 2026-05-28 Buy
aablocks AA00DB4J 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97% 1g $296 2026-05-28 Buy
aablocks AA00DB4J 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97% 5g $1063 2026-05-28 Buy
aablocks AA00DB4J 4-[[4-[[4-[(1E)-2-Cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile 97% 10g $1653 2026-05-28 Buy
ACHEMBLOCK 10410 Rilpivirine 98% 5G $850 2026-05-27 Buy
ACHEMBLOCK 10410 Rilpivirine 98% 1G $240 2026-05-27 Buy
ACHEMBLOCK 10410 Rilpivirine 98% 100MG $55 2026-05-27 Buy
Adipogen Life Sciences AG-CR1-3750-M005 Rilpivirine ≥98%(HPLC) 5mg $50 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-3750-M025 Rilpivirine ≥98%(HPLC) 25mg $200 2021-12-16 Buy
Adipogen Life Sciences AG-CR1-3750-M025 Rilpivirine ≥98%(HPLC) 25mg $200 2026-05-06 Buy
Adipogen Life Sciences AG-CR1-3750-M100 Rilpivirine ≥98%(HPLC) 100mg $430 2026-05-06 Buy
Next Last

Properties

Melting point :245℃
Boiling point :634.1±65.0 °C(Predicted)
Density :1.27
storage temp. :Refrigerator
solubility :Acetone (Slightly), Chloroform (Slightly), DMSO (Slightly), Water (Very Slightly)
form :Solid
pka :4.56±0.10(Predicted)
color :Yellow
InChI :InChI=1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+
InChIKey :YIBOMRUWOWDFLG-ONEGZZNKSA-N
SMILES :C(#N)C1=CC=C(NC2=NC=CC(NC3=C(C)C=C(/C=C/C#N)C=C3C)=N2)C=C1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)Environment (GHS09)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning P273, P391, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning P273, P391, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330 Rinse mouth.
P391 Collect spillage. Hazardous to the aquatic environment
P501 Dispose of contents/container to..…

Description

In May 2011, the U.S. FDA approved rilpivirine in combination with other antiretroviral agents for the treatment of human immunodeficiency virus (HIV) 1 infection in treatment-naive adult patients. Rilpivirine is a member of the nonnucleoside reverse transcriptase inhibitor (NNRTI) class of anti-HIV agents. It is highly potent against a range of wild-type HIV strains (EC50=0.07–1.0 nM),～10–20 timesmore potent than the NNRTI efavirenz (Sustiva), and active against HIV strains resistant to other NNRTIs. The discovery of rilpivirine was guided by molecular modeling and X-ray crystallography of HIV-1 RT complexed with inhibitors. The synthesis of rilpivirine is accomplished by an efficient 6-step route in which the key step is coupling of 4-((4-chloropyrimidin-2-yl)amino)benzonitrile with (E)-3-(4-amino-3,5-dimethylphenyl)acrylonitrile.

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Suppliers and manufacturers

Hebei Yanxi Chemical Co., Ltd.
rilpivirine
$0.00 /1KG
rilpivirine CAS:500287-72-9
Hefei Lbao Physical & Chemical Science Co.,Ltd
(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile
$0.00 /1kg
(E)-4-((4-((4-(2-Cyanovinyl)-2,6-dimethylphenyl)amino)pyrimidin-2-yl)amino)benzonitrile CAS:500287-72-9
career henan chemical co
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile
$2.00 /1kg
4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethyl-phenyl]amino]pyrimidin-2-yl]amino]benzonitrile CAS:500287-72-9
Capot Chemical Co.,Ltd.
Henan Tianfu Chemical Co.,Ltd.
Nanjing ChemLin Chemical Industry Co., Ltd.
ATK CHEMICAL COMPANY LIMITED
Shaanxi Yikanglong Biotechnology Co., Ltd.
Biochempartner
BOC Sciences